on a transplantable mouse tumor sarcoma 180. Indian J. Exp. Biol. 1993;31:607–611. [PubMed] 8 9. Kandil FE‚ Elsayeh NH‚ Abou-Douh AM‚ Ishak MS‚ Mabry TJ. Flavonol glycosides and phenolics from Withania somnifera. Phytochemistry. 1994;37:1215–1216. 10. Bhattacharya SK‚ Satyam SK‚ Chakrabarti A. Effect of Trasina an Ayurvedic herbal formulation‚ on pancreatic islet superoxide dismutase activity in hyperglycaemic rats. Indian J. Exp. Biol. 1997;35:297–299. [PubMed] 11 12. Andallu B‚ Radhika B‚ Dawar
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most cytokines. STATs represent a family of conserved proteins‚ seven of which have been identified in mammals (i.e.‚ Statl‚ 2‚ 3 ‚ 4 ‚ Say5b‚ and 6; Darnell‚ 1997; Ihle et al.‚ 1994; Schindler and Darnell‚ 1995). Homologues have also been identified in lower eukaryotes (Hou et al.‚ 1996; Kawata et al.‚ 1997; Yan et al.‚ 1996).JAKs are receptor-associated tyrosine kinases‚ which mediate the ligand dependent activation of STATs. These two protein families are the defining components of the JAK-STAT
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Immunity & Ageing Research BioMed Central Open Access Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity Andres Kriete*1‚2‚ Kelli L Mayo1‚2‚ Nirupama Yalamanchili1‚ William Beggs2‚ Patrick Bender2‚ Csaba Kari3 and Ulrich Rodeck3 Address: 1School of Biomedical Engineering‚ Science and Health Systems‚ Drexel University‚ Bossone Research Center‚ 3141 Chestnut Street‚ Philadelphia‚ PA 19104‚ USA‚ 2Coriell Institute
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Nehru University‚ New Delhi‚ India‚ 2 School of Information Technology‚ Jawaharlal Nehru University‚ New Delhi‚ India Abstract CaMdr1p is a multidrug MFS transporter of pathogenic Candida albicans. An over-expression of the gene encoding this protein is linked to clinically encountered azole resistance. In-depth knowledge of the structure and function of CaMdr1p is necessary for an effective design of modulators or inhibitors of this efflux transporter. Towards this goal‚ in this study‚ we have
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Determination of the Migration Potential in Breast and Lung Cancer Cells in presence of antimigratory therapeutic agent. Marco Brudik and Paloma Aranzazu Godinez Melgoza Medical and Pharmaceutical Biotechnology Program‚ University of Applied Sciences IMC FH Krems. Abstract. The new trends on research points to study the process of tomour-cell invasion and metastasis for developing and testing of anti-migratory agents. The present study develops a quantitative determination of the cancer cell’s
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the name given to these mathematical and computing approaches used to glean understanding of biological processes. Common activities in bioinformatics include mapping and analyzing DNA and protein sequences‚ aligning different DNA and protein sequences to compare them and creating and viewing 3-D models of protein structures. The primary goal of bioinformatics is to increase the understanding of biological processes. What sets it apart from other approaches‚ however‚ is its focus on developing and
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G Model JMG-5899; No of Pages 17 Journal of Molecular Graphics and Modelling xxx (2009) xxx–xxx Contents lists available at ScienceDirect Journal of Molecular Graphics and Modelling journal homepage: www.elsevier.com/locate/JMGM Genome wide analysis and comparative docking studies of new diaryl furan derivatives against human cyclooxygenase-2‚ lipoxygenase‚ thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway P. Nataraj Sekhar a‚ L. Ananda Reddy a
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This article was downloaded by: [Universiti Teknologi Malaysia] On: 03 January 2015‚ At: 02:59 Publisher: Taylor & Francis Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House‚ 37-41 Mortimer Street‚ London W1T 3JH‚ UK Bioengineered Publication details‚ including instructions for authors and subscription information: http://www.tandfonline.com/loi/kbie20 Cloning‚ soluble expression‚ and purification of the RNA polymerase II subunit RPB5 from Saccharomyces
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substantially more USV calls and these were characterized by a significantly lower frequency and amplitude compared with female rat pups. Moreover‚ the dam was more likely to first retrieve male pups back to the nest‚ then females. The amount of Foxp2 protein was significantly higher in multiple regions of the developing male brain compared with females and a reduction of brain Foxp2 by siRNA eliminated the sex differences in USVs and altered the order of pup retrieval. Our results implicate Foxp2 as a
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Oncotarget‚ November‚ Vol.1‚ No 7 www.impactjournals.com/oncotarget/ Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Joshua C. Curtin and Matthew V. Lorenzi 1 Oncology Drug Discovery‚ Research and Development‚ Bristol-Myers Squibb‚ Princeton‚ NJ‚ USA Correspondence to: Matthew V. Lorenzi‚ e-mail: Matthew.Lorenzi@bms.com Keywords: oncotarget‚ cancer‚ stem cells‚ wnt‚ drug discovery Received: August 8‚ 2010‚ Accepted: October 27‚ 2010‚ Published: October 30‚
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