Oncotarget‚ November‚ Vol.1‚ No 7 www.impactjournals.com/oncotarget/ Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Joshua C. Curtin and Matthew V. Lorenzi 1 Oncology Drug Discovery‚ Research and Development‚ Bristol-Myers Squibb‚ Princeton‚ NJ‚ USA Correspondence to: Matthew V. Lorenzi‚ e-mail: Matthew.Lorenzi@bms.com Keywords: oncotarget‚ cancer‚ stem cells‚ wnt‚ drug discovery Received: August 8‚ 2010‚ Accepted: October 27‚ 2010‚ Published: October 30‚
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E r J. Biochem. 40‚177-185 (1973) u. Intracellular Titration of Cyclic AMP Bound to Receptor Proteins and Correlation with Cyclic-AMP Levels in the Surviving Rat Diaphragm Lien DO KHAC‚Simone HARBON Hubert J. CLAUSER and lnstitut de Biochimie‚ Universit6 de Paris-Sud‚ Orsay (Received April 9/July 17‚ 1973) Extracts prepared from rat diaphragms incubated with or without theophylline and/or epinephrine have been tested for their total cyclic AMP content and for their ability to bind exogenously
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Determination of presence of protein in a variety of food substances by the use of Biuret Reagent Biol. 1040 Section 1005 Introduction The human body consumes carbohydrates‚ lipids‚ and proteins each day by eating a variety of foods. These foods are required for energy and human growth. Proteins are a diverse group of macromolecules with many different functions (Mbuthia‚ 2012). Many are structural components of bone‚ muscle‚ hair‚ tissue‚ etc. Others are enzymes that speed up cellular
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we have to take every day‚ therefore we would like to identify the types of macromolecules that contain in some of the food or solution in order to maintain a healthy life. There are four groups of macromolecules which are carbohydrates‚ lipids‚ proteins and nucleic acid. They are mostly made up of hydrogen‚ carbon‚ oxygen‚ nitrogen‚ sulphur and phosphorus. 1. Carbohydrates Carbohydrates are organic compounds that with the combination of carbon‚ hydrogen and oxygen in a 1:2:1 ratio. Carbohydrates
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Global J. of Mod. Biol. & Tech.‚ 2012: 2 (3) Research Paper: Arunkumar et al.‚ 2012: Pp.68-72. ISOLATION AND CHARACTERIZATION PHYTASE PRODUCING MICROBES FROM POULTRY SOIL SAMPLE Arunkumar.R.‚ Bharath Chandra Sugunesh. G and A.M. Vinothkumar Dept. of Biotechnology‚ Prathyusha Institute of Technology and Management‚ Thiruvallur-25. ABSTRACT Phytase producing thirteen microbial strains were identified in poultry soil sample collected at Sathyamangalam‚ Erode district‚ Tamilnadu. Among thirteen isolates
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transformation and the origin of translation Prog. Biophys. Mol. Biol.‚ 54 (1989)‚ pp. 81–86 Article | PDF (496 K) | View Record in Scopus | Citing articles (47) de Duve‚ 1991 C Blueprint for a Cell: The Nature and Origin of LifeNeil Patterson Publishers‚ Carolina Biological Supply Company‚ Burlington‚ NC (1991) Di Giulio‚ 1992 M. Di Giulio On the origin of the transfer RNA molecule J. Theor. Biol.‚ 159 (1992)‚ pp. 199–214 Di Giulio‚ 1995 M J. Theor. Biol.‚ 177 (1995)‚ pp. 95–101 Article | PDF (617 K) | View
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Cofilin is activated upon dephosphorylation allowing it to bind to the actin cytoskeleton hence enabling its depolymerization activities leading to actin assembly and remodeling of the cytoskeleton [1315]. Two proteins are involved in the regulation of Cofilin; LIM-kinase (LIMK) acts to phosphorylate and deactivate Cofilin resulting in polymerization and stabilization of actin Page 1 of 7 filaments thus suppression of actin turnover whereas Slingshot phosphatase
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MINIREVIEW Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics ANDREW R. HILGENBRINK‚ PHILIP S. LOW Department of Chemistry‚ Purdue University‚ West Lafayette‚ Indiana 47907 Received 25 May 2005; accepted 27 June 2005 Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jps.20457 ABSTRACT: Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its
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14 The Open Geriatric Medicine Journal‚ 2008‚ 1‚ 14-23 Open Access Sarcopenia: Current Clinical and Research Issues Matteo Cesari*‚1‚ Alessandro Ferrini2‚ Valentina Zamboni2 and Marco Pahor1 1 Department of Aging and Geriatric Research‚ University of Florida‚ Institute on Aging‚ Gainesville‚ FL‚ USA 2 Department of Gerontological‚ Geriatric and Physiatric Sciences‚ Catholic University of Sacred Heart‚ Rome‚ Italy Abstract: Sarcopenia is the age-related progressive decline of
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o glucagon o cortisol o oestrogen o growth hormone o catecholamines In addition‚ several cytokines such as IL1‚ IL6 and TNF alpha antagonise the effects of insulin. [J Biol Chem 2001 Jul 13;276(28):25889-93] It is thus not surprising that many causes of stress and/or the systemic inflammatory response syndrome‚ appear to precipitate DKA in patients lacking insulin. Mechanisms by which these hormones and cytokines antagonise
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