1–16; May 2013; © 2013 Landes Bioscience Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance Wen Yue‚1‚2‚† Ahmed hamaï‚1‚2‚† Giovanni Tonelli‚1‚2 chantal Bauvy‚1‚2 Valérie Nicolas‚2‚3 hugo Tharinger‚2‚3 Patrice codogno1‚2 and Maryam Mehrpour1‚2‚* 1 † These authors contributed equally to this work. Keywords: breast cancer stem-like/progenitor cell‚ salinomycin‚ autophagy‚ cell death‚ lysosome Abbreviations: ACTB‚
Premium Cancer Breast cancer Apoptosis
Although breast self-examination does not reduce the incidence of breast cancer‚ it does markedly reduce the rate of mortality‚ since most early tumors are found by women themselves. I discovered my own tumor upon a monthly breast exam‚ and so report most of the other women I know with a good prognosis for survival. With our alert awareness making such a difference in the survival rate for breast cancer‚ women need to face the possibility and the actuality of breast cancer as a reality rather than
Premium Cancer Breast cancer Oncology
NIH-PA Author Manuscript Altered EGFR Localization and Degradation in Human Breast Cancer Cells with an Amphiregulin/EGFR Autocrine Loop Nicole E. Willmartha‚b‚ Andrea Baillob‚ Michele L. Dziubinskib‚ Kristy Wilsonc‚ David J. Riese IIc‚ and Stephen P. Ethierb‚1 a Department of Cancer Biology‚ Kimmel Cancer Institute‚ Thomas Jefferson University‚ Philadelphia‚ PA‚ USA 19107 b Breast Cancer Program‚ Karmanos Cancer Institute‚ Department of Pathology‚ Wayne State University School of Medicine‚ Detroit
Premium Signal transduction Breast cancer Cancer
Breast reconstruction is a type of surgery that helps people recover from a devastating experience. Whether it is needed due to cancer treatment or severe injury‚ restoring the natural shape and position of the breast‚ or even doing a breast augmentation‚ helps many patients achieve a fuller recovery. There are a few different types of breast reconstruction surgery available. Let’s look at the options available here at Proffer Surgical. DIEP Flap Sometimes after a mastectomy‚ there is not enough
Premium Cancer Oncology Breast cancer
Breast self-examination knowledge and skills is an important facet in early detection of breast cancer. 3‚ 20 Although our study found high awareness of BSE among female university students‚ BSE practices were found to below as observed from the number of female students who had performed BSE at the time of the study. Even those who attempted to perform BSE‚ fewer had performed BSE once a month. Those that had not attempted BSE‚ still few could promise to perform BSE in the next month. Poor BSE practices
Premium Cancer Breast cancer Pregnancy
Breast Cancer and Cervical Cancer Many women do not take breast cancer or cervical cancer serious‚ by getting screened‚ until the disease has begun to develop or has spread. Cervical cancer use to be the main cause of deaths caused by cancer for women‚ but over the past forty or fifty years‚ the number of cases of cervical cancer and the number of deaths from this disease has decreased significantly‚ leaving another horrible disease in its place. Now breast cancer is the second major cause of
Premium Cancer Human papillomavirus Breast cancer
INTRODUCTION "Your mammogram is suspicious for breast cancer" "Your biopsy was positive for breast cancer." These are among the most terrifying words a woman can hear from her doctor. Breast cancer elicits so many fears‚ including those relating to surgery‚ death‚ loss of body image and loss of sexuality. Managing these fears can be facilitated by information and knowledge so that each woman can make the best decisions concerning her care. Optimally‚ these issues are best discussed with the patient’s
Premium Nursing Breast cancer Nursing theory
Cancers affecting mankind To date‚ none of the approximately 60 anticancer drugs used in conventional chemotherapy exhibits a selective uptake in tumor tissue and generally only a very small fraction of the administered dose reaches the tumor site. If surgery or radiotherapy is not effective‚ cure rates are in the range of 10% and‚ as a consequence‚ 90 % of chemotherapeutic agents are administered in the palliative setting to stabilize the disease or to improve the quality of life. With such a
Premium Cancer Oncology Chemotherapy
Have you ever wondered how cancers formed? Cancer is caused in many ways‚ some are worse than others. There are also a lot of different ways to cure cancer. Thyroid cancer is cancer that can be caused by many things. Thyroid cancer kills people all the time. Any Type of cancer is bad and can kill you. Cancer is very serious. There are many types of cancer‚ but Chernobyl caused a special kind. Chernobyl caused many types of cancer. That special kind is thyroid cancer‚ it’s located on the bottom
Premium Cancer Oncology Chemotherapy
Cancer has had an increasing impact in our world and the lives of others. The factors of this disease are all around us. Cancer can be caused by dangerous environmental substances called carcinogens‚ which are substances that are known to cause cancer. Overall‚ this disease is caused by changes in genes and it alters the way our cells function. Exposure to particular environmental substances can cause damage to your DNA. Some of these exposures are things such as chemicals‚ tobacco smoke‚ or even
Premium Cancer Oncology DNA