Quinazolines are the class of chemical compounds that are pharmacologically important as therapeutic agents. They are utilized as drugs and employed in cancer chemotherapy. They act by various mechanisms. Some of them act by inhibiting antifolat thymidylate syntheses‚ while some other derivatives inhibit tubulin polymerization. They were also found to inhibit the epidermal growth factor receptor (EGFR) tyrosine kinase over expression through the inhibition of autophosphorylation of EGFR. Further
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Abstract Background: Tamoxifen (TMX) is a synthetic drug that is used for treatment of breast cancer. Despite the beneficial effects of TMX‚ the use of this drug has several side-effects in these patients. Non-alcoholic fatty liver disease (NAFLD) is a well-known adverse effect of TMX. Silybum marianum is the most researched plant in the treatment of liver disease. Objectives: In this study the effect of Silybum marianum extract (SME) on histological and biochemical parameters in the TMX treated
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Case for Seminars 2 and 3: Stephen is a board director of StarAlphaMedicines‚ a multinational pharmaceutical company headquartered in the UK. The company’s Research & Development department are working on a novel breast cancer drug. The drug could provide breakthrough treatment for millions of women in the company’s core markets in Europe and the US‚ and is likely to be a source of high revenue for StarAlphaMedicines‚ which has recently seen a fall in profits and a resulting drop in share price
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FDBP1001 – F1(A) TASK Purpose of ASDA ASDA is the second largest retailer in the UK‚ and it has been the largest subsidiary of the Wal-Mart family of companies since 1999. ASDA’s scale can be appreciated by the number of stores it runs as well as how many people work for it. For example‚ it has 321 stores across the UK and Northern Ireland‚ 29 depots and more than 148‚000 colleagues. These all help to generate more than £15 billion of turnover. Managers who make decisions that affect the route
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know that it is most important to do so. Three years ago‚ my mother was diagnosed with breast cancer. The news came as an utter shock to everyone‚ considering the fact that she was one of the healthiest and most active members of my family. She played tennis and practiced yoga at least four times a week; always ate healthy and organic foods‚ and on top of all this‚ there was barely any history of breast cancer on our family tree! Though her case was not as bad as others‚ it still required her to
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patients with oral premalignant lesions‚ does the use of Thymoquinone (TQ) prevent malignant transformation compared to a placebo? Justification for undertaking the trial: Over the past three decades oral cancer –although can be avoided- possess a low survival rate nearly around five years. Oral cancer arises from potentially malignant conditions as leukoplakia‚ erythroplakia‚ oral lichen planus and other disorders including oral submucous fibrosis (Jainkittivong et al. 2002). All stages of dysplasia
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phenomenon of gang‚ sex‚ and media has entered into the debate over school dress codes. Before‚ dress codes were simple. In the San Diego area; the Sweetwater Union High School District has banned any clothing that reveals the so-called three B’s: breasts‚ bellies or bottoms. (Johnson). This dress code is understandable and seems very reasonable for an educational environment or any public environment. Students would still be able to express themselves and also not have to worry about getting punished
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From breast cancer to cervical cancer these are the types of cancers that women are more prone to have or be familiar with. Vaginal cancer is a rare cancer that occurs in your vagina the‚ muscular tube that connects your uterus with your outer genitals. Vaginal cancer most commonly occurs in the cells that line the surface of your vagina‚ which is sometimes called the birth canal. While several cancers can spread to your vagina from other places in your body‚ cancer that begins in your vagina (primary
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Breast cancer is a disease that impacts almost everyones lives‚ whether it be them personally‚ or a loved one around them.I’m no exception‚ i lost my mother to breast cancer when i was very young‚ and I’m not the only one. With it impacting so many lives‚ it would make sense that it is a very well known disease with many organizations dedicated to finding a cure. Easily one of the most prominent ones being the Susan G Komen for the Cure organization. This organization is the one with the pink ribbons
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The Design Brief The McGrath foundation has given me the opportunity to host a high tea in memory of the cofounder Jane McGrath and anyone who has lost their battle to breast cancer. The tea is set to commence on the 15th of May‚ I am hoping to encourage the small community to get actively involved. Each year around Australia high teas are set up to honor and remember anyone who has lost their battle‚ the day is also about having a good time and donating to the foundation to help raise money to
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