Purification of Acetanilide by Recrystallization Method Dupaya‚ Julian Victor M. Estacio‚ Jerwin Caesar A. Farnacio‚ Rebecca Ruth Gabito‚ Jose Luis F. Gallo‚ Cian Carlo M. Galvez‚ Joshua M. Group no.4‚ 2D-Medical Technology‚ Faculty of Pharmacy‚ University of Santo Tomas ABSTRACT Recrystallization is a method for purifying solid organic compounds. The process is dissolving the solid to be purified in a hot solvent and cooling the solution slowly‚ this allows impurities with different
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Recrystallization Abstract: Technical grade aniline was reacted with acetic anhydride to give acetanilide a dark brown color‚ due to the presence of impurities. Crystallization of the crude product from water was combined with decolorization with activated carbon‚ furnished pure acetanilide as white flakes‚ melting point 112-115°C‚ yield 70.3%. Experimental: 2 grams of technical grade aniline and 15ml water were placed in a 125ml Erlenmeyer flask. Then‚ 2.5ml of acetic anhydride was
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the weight and melting point of the final version of the sample. I began the lab with 1.5 grams of the impure acetanilide solute and ended the lab with 0.05 grams of pure acetanilide crystals. The percentage of pure acetanilide I recovered during this lab was 3.33%‚ which is lower than I expected. However‚ the low percentage shows that the impurities within the original impure acetanilide solute were removed. A number of factors could have caused the low yield of pure crystals. The melting
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compound. The methods used to achieve this objective were also hot vacuum filtration in order to remove suspended solid impurities‚ and isolating the pure acetanilide. In the next lab‚ percent recovered was obtained through weighing the acetanilide sample as well as comparing its melting point range. In this experiment‚ the sample‚ acetanilide was weighted to be 1.523 grams. The sample appeared to be a pale mixture of brown flakes before it was crushed into small flakes. When boiling the sample with
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EXPERIMENT 5 - Preparation of Acetanilide Preparation and purification of Acetanilide [pic] Purpose: a) To synthesis acetanilide by reaction of aniline and acetic anhydride. b) To purify acetanilide by crystallization method from water c) Purity check by melting range Equipment / Materials and Hazars: hot plate beakers(150‚250mL) ice stirring rod spatula Büchner
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must be discovered. Panacetin tablets are known to contain aspirin‚ acetaminophen‚ and sucrose; therefore‚ the tablets tested‚ containing aspirin and sucrose‚ are thought to contain an unknown of something similar to that of acetaminophen such as acetanilide or phenacetin. Another problem trying to be sought out in the experiments is whether or not the composition of Panacetin as stated on the label is accurate. The experiment involved the separation of the unknown from the Panacetin by first isolating
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Organic Chemistry Laboratory ABSTRACT In this experiment‚ acetanilide was used as the pure organic compound. Acetylation of aniline and acetic anhydride yields the crude product or crude acetanilide. The crude acetanilide was purified by dissolving it in hot water and then the solution was cooled slowly by placing in an ice bath. The yielded crystals were pure acetanilide since molecules of other compounds present in the crude acetanilide were excluded from the growing crystal lattice. Lattice is
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crystals of pure compound. Impurities are excluded from the growing crystals and the pure solid crystals can be separated from the dissolved impurities by filtration. Chemical requirement. Solvent: Distilled water‚ Ethanol‚ and Acetone. Solute: Acetanilide. Result: Data and Report Sheet. 1.1 Choosing a suitable solvent. Solvents | solubility | Appearances and quantity of the crystal at room temperature | | Room temperature
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Title: Acetanilide Synthesis Objective: To synthesize Acetanilide by recrystallization. To check its purity by calculating its percent yield. Introduction: Aniline is a primary aromatic amine and weak base which forms salts with mineral acids. In acidic solution‚ nitrous acid converts aniline into a diazonium salt that is an intermediate in the preparation of a great number of dyes and other organic compounds of commercial interest. When aniline is heated
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Name: Date: Lab Section: Selected Known Compounds Name Structural Formula Literature Melting Point Acetanilide C8H9NO 114.3°C Fluorene C13H10 116.5°C Experimental Data Sample Composition 1. 100% Acetanilide 2. 10% Acetanilide 3. 25% Acetanilide 4. 50% Acetanilide Fluorene 5. 75% Acetanilide 6. 90% Acetanilide 7. 100% Fluorene Melting Range 108-116°C 108-112°C 105-112°C 102-109°C 105-112°C 109-115°C 108-114.5°C Graph of Data Discussion
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