Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans Autophagy‚ translated from Greek means to ‘self eat’. It is a basic catabolic mechanism involving cell degradation of unwanted or dysfunctional cellular components through the lysosome. Autophagy has been speculated to alter lifespan in organisms. Autophagy is triggered in response to varied stress and physiological conditions like food deficit‚ hyperthermia‚ etc. At molecular level‚ an autophagy pathway
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Abstract The body of Caenorhabditis elegans (C. elegans) are surrounded by a cuticle that is molted four times in development although not all cuticle collagen genes are expressed at once. Mutations in these genes lead to morphological defects such as blister formation in the cuticle. The blister phenotype (Bli) is inherited recessively and develop in the adult stage of C. elegans. Other cuticle collagen mutations‚ such as the uncoordinated (unc)‚ roller (rol) and dumpy (dpy) mutations‚ can suppress
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Introduction: In this essay I will talk about two kinds of organisms that are called worms. That’s organisms use it in a labs. Which are the flatworm and the roundworms. However‚ every kind belongs to different phylum‚ so they are not closely related to each other. Flatworms ( phylum Platyhelminthes) and roundworms ( phylum Nematoda)‚ but there are many similarities and differences between these two types of organisms. Similarity: • There are many similarities between the two groups of worms‚ Platyhelminthes
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An adult hermaphrodite of C. elegans has the lesser amount of internal tissues and organs with unsegmented‚ bilaterally symmetrical‚ a cylinder-shaped body that is pointed at the ends. It has an outer covering (i.e.‚ body wall made up of cuticle‚ hypodermis‚ neurons‚ muscles and excretory and an inner tube contains the pharynx‚ intestine. An outer tube and an inner tube is partitioned by pseudocoelomic space and also the tissues controlled by an osmoregulatory system. In C.elegans head‚ the pharynx
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Abstract By understanding how components within certain cells confer their ability to regenerate or antagonize cellular differentiation into specific cell types‚ we can change these components to make our cells have regenerative properties. To understand this‚ we examine cells of the germline‚ called germ cells. These "parent" cells of sperm and egg cells have the ability to become any cell type of each subsequent generation‚ and are thereby totipotent. This totipotency essentially makes germ cells
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Kenneth Reynolds C. Elegans Paper April 20‚ 2013 Dr. Yong Xiang C. Elegans – Wonderful Creatures of Science! We have been studying genetics recently in BIO and I have realized that I actually do find genetics really interesting‚ because of its complexity and probability. The different combinations and variables make it very interesting to me‚ an avid risk take and gambler‚ because of the unknown. Genetics make – up a huge portion of how we act‚ interact with others‚ our appearance entails
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1.3 C. elegans sensory system C. elegans is a simple multicellular organism‚ and‚ like other animals‚ it constantly perceives environmental cues and elicits appropriate physiological responses. Remarkably‚ this process is achieved with only a small number of neurons. An adult C. elegans hermaphrodite nervous system harbors 302 neurons‚ which have been grouped into 118 distinct classes according to their topology and synaptic connection pattern (Ward‚ 1975 #4;Sulston‚ 1977 #8;Sulston‚ 1983 #9;Ward
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C.elegans Research Project Madison Wall A. C. elegans is an ideal organism to use for studying aging because it is generally small in size and has a rapid lifespan. (http://cmgm.stanford.edu/~kimlab/index_wormaging.html). The organism also shares many essential biological characteristics that cause problems in human biology.(Edgley 2014). Worms can be genetically mutated fairly easily because of their 4-day generation time‚ where it develops from an egg to an adult with a maximum length of 1.5mm
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Examining the RNA Interference Mechanism in the dpy-13 Gene in C. Elegans Through Feeding Mehdi Misto Lab: Monday 1:00 – 4:50 PM 11 December 2012 Introduction: RNA interference‚ or RNAi‚ is a biological process in which RNA molecules reduce the gene expression of an organism. This is done typically by causing the destruction of specific mRNA molecules. RNAs are direct products of genes‚ these small RNAs can bind to other mRNA molecules to either increase or decrease their activity like in the example
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Transport of vesicles facilitated by kinesin and the effects of mutations in nerve transmission in Caenorhabditis elegans Introduction A nerve cell is made up of three main structures: the soma‚ the axon and the synapse. When a nerve cell receives a signal‚ a protein called kinesin travels anterograde along the axon and guides the synaptic vesicles until it reaches the synapse. This triggers the release of the neurotransmitters stored within the vesicles. Once released‚ the neurotransmitters then
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