Oncotarget‚ November‚ Vol.1‚ No 7 www.impactjournals.com/oncotarget/ Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Joshua C. Curtin and Matthew V. Lorenzi 1 Oncology Drug Discovery‚ Research and Development‚ Bristol-Myers Squibb‚ Princeton‚ NJ‚ USA Correspondence to: Matthew V. Lorenzi‚ e-mail: Matthew.Lorenzi@bms.com Keywords: oncotarget‚ cancer‚ stem cells‚ wnt‚ drug discovery Received: August 8‚ 2010‚ Accepted: October 27‚ 2010‚ Published: October 30‚
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Extra-Corporeal Membrane Oxygenation (ECMO) is a life-saving treatment for severe respiratory failure irresponsive to mechanical ventilation‚ associated or not with haemodynamic instability‚ and its application fields are widening to refractory sepsis and also to elective thoracic procedures. ECMO is replacing conventional cardio-pulmonary by-pass (CPB) even during lung transplantation due to its potential advantages: the absence of full-anticoagulation and the possibility of maintaining the extra-corporeal
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The Killer Tan The use of tanning beds has become increasingly popular in minors and young adults. Teenagers see celebrities on TV and in magazines with glowing tans‚ and think they need to have this perfectly bronzed look year round. Some question how they are able to keep their sun kissed skin during the winter. This often leads young adults to visit tanning salons so they can achieve the desired “healthy glow”. After a few sessions in a tanning bed the skin pigment starts to darken toward the
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"Before death I hope to obtain life." This quote reminds me of my Michigan Hero Danielle Nash. Danielle was my cousin who was diagnosed with stage four Melanoma and Brain Cancer at age 26. Before cancer‚ she opened her own Day Care/ Preschool in Whitehall called Bright Futures‚ she was only 21. She also started the first Middle School Competitive Cheerleading Team in Reeths Puffer and was also the head coach of the Varsity Reeths Puffer Competitive Cheerleading team. She lived in the Whitehall area
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Diarrhea describes bowel movements (stools) that are loose and watery. It is very common and usually not serious. Many people will have diarrhea once or twice each year. It typically lasts two to three days and can be treated with over-the-counter (OTC) medicines. Some people have diarrhea often as part of irritable bowel syndrome or other chronic diseases of the large intestine. Doctors classify diarrhea as "osmotic‚" "secretory‚" or "exudative."Osmotic diarrhea means that something in the bowel
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carcinogens include occupational exposures such as nickel refining‚ exposure to textile fibers‚ and woodworking. Use of marijuana‚ especially while younger‚ is linked to an increase in squamous-cell carcinoma cases while other studies suggest use is not shown to be associated with oral squamous cell carcinoma‚ or associated with decreased squamous cell
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1. First‚ Henry should put clothing on Mark. Although Mark may feel very hot‚ his skin has already been exposed to the intense UV sunrays for a long time. Continuing to stay in the sun will worsen Mark’s sunburns. Henry should also start administering Mark on diluted fluids that contain essential electrolytes. This will help restore hydration to Mark’s body without running the risk of his plasma becoming hypotonic. Mark has lost a lot of water through sweat and this combined with the intense heat
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Antibiotics are medications used to kill or prevent the spread of disease causing bacteria in the body. There are two types of antibiotics which manage infectious diseases differently: 1. Bactericidal Antibiotics: this is when the antibiotic completely kills off the Bacteria. It does this by damaging or interfering with the bacteria’s cell contents or wall. An example of this type of antibiotic is Penicillin which is in fact the first type of antibiotic to be discovered. 2. Bacteriostatic Antibiotics:
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adolescents. Allowing minors to tan may result in health consequences. Skin cancer is one of the most common types of cancer across the nation. There are three kinds: basal‚ squamous and melanoma. Basal and squamous are not as dangerous and do not occur as often as melanoma. The occurrence of melanoma‚ the most lethal form of skin cancer‚ has doubled in the U.S. since 1975 among women ages 15 to 29 (Hawaleshka‚ Danylo).
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paralysis is a)C5‚C6 B)C6‚C7 C)C8‚T1 D)T1‚T2 12)For the treatment of a patient with after cataract which laser is used a)LASIC b)YAG c)excimer d)Argon 13)Most malignant breast tumor of the following is a)inflammatory carcinoma b)Mucinous carcinoma c)Colloid carcinoma d)Paget’s` disease of breast. 14)Full thickness graft means: a)Only epidermis b)epidermis and superficial dermis c)epidermis + whole dermis d)epidermis‚ dermis and subcutaneous tissue 15)A 50yr old woman weighing
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