Oncotarget‚ November‚ Vol.1‚ No 7 www.impactjournals.com/oncotarget/ Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Joshua C. Curtin and Matthew V. Lorenzi 1 Oncology Drug Discovery‚ Research and Development‚ Bristol-Myers Squibb‚ Princeton‚ NJ‚ USA Correspondence to: Matthew V. Lorenzi‚ e-mail: Matthew.Lorenzi@bms.com Keywords: oncotarget‚ cancer‚ stem cells‚ wnt‚ drug discovery Received: August 8‚ 2010‚ Accepted: October 27‚ 2010‚ Published: October 30‚
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prescription drug abuser. She even tried killing herself with a drug overdose‚ and had to have her stomach pumped out. Here are her parents! Mr. and Mrs. Smith: We are scared for her life‚ as a parent you can just do so much. She started abusing when her boyfriend broke up with her and she was so depressed and started taking antidepressant pill. Till she hurt herself by falling and got pain killers‚ she started relying on the drugs. When she ran out‚ she started using different over the counter drugs. She
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Boston Fights Drugs 1. Would you have selected focus groups for your methodology? Why or why not? I would have chosen to do the focus groups out of the three as the methodology for this research as the group did. With the one on one interviews the researchers had to find kids/adolescence that would actually talk to them‚ and be honest about their habits to a complete stranger. This problem would eliminate a majority of the kids‚ but for the ones that were left I think the research would show
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The University of Central Florida managed to take in just 11.25 pounds of medication during its seventh-annual Drug Take Back Day on Wednesday. That’s a fair share less than the 75-pound average per outing since it began. But that number may be due in part to UCF’s two medication drop-off boxes that were installed on campus. In cooperation with the Drug Enforcement Agency‚ the UCF Police Department partnered with UCF Health services to get unused and expired over-the-counter and prescription medicines
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The Report begins with an executive summary in order to explain the Situation of Marks & Spencer hence it follows an analysis of their predicament. Marks & Spencer was founded in 1894. In 1926 M&S is floated on the London stock exchange. They became more international in the year of 1973 with their first overseas store in Canada and in 1975 they build up stores in Paris and Brussel. In the year 1997 M&S profits exceeded £1billion. Finally Marks & Spencer became an international company‚ which spread
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America faced a severe drug epidemic. The rise of drug use led to an increase in crime. Incarceration rates nearly tripled due to drug related crimes. The need to address this growing problem led to the drug court movement and the creation of drug courts. Drug courts are special courts that treat offenders with a history of substance abuse addictions by providing supervised treatments and sanctions when needed. This paper will discuss the establishment and goals of drug courts. It will also discuss
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“I Need To Be Myself‚ I Can’t Be Anyone Else.” “I was born to be true and not to be perfect‚” Epey said in his speech. Epey is the winner of the trending segment in It’s Showtime – That’s My Tomboy. In this segment‚ they (lesbians) let me‚ the madlang people and the world to see their worth as a lesbian and as a human. They also made me believe that all of us can be accepted in the society beyond our imperfections‚ because no matter how imperfect we are‚ there are still things that we must be proud
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Philadelphia policymakers actively searched for a beneficial solution to their war-on-drugs‚ but remained mindful of the government’s overarching rule and contrasting beliefs. One of the largest disputes between local and federal was the handling of drug-related charges‚ most notably with the sentencing of offenders. The federal government set a precedent of allowing each offender to receive a fair trial‚ but their initial beliefs of strict enforcement were not abandoned. Though each offender would
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Europe’s Age of Discovery which began in the early 15th century and ended around the early 17th century changed world and paved the way for the modern world as we know it. Explorers traveled the seas‚ discovering new places and routes for trade and travel making daring journeys out across the seas and then navigating their way back home to report on their discoveries. This paper will discuss will discuss the discovery of these new places and the tools that made those discoveries possible as well
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Why us is penicillin the miracle drug? We all know that penicillin is one of the top known class of antibiotics prescribed today. Although this drug has been getting numerous applauds since the mid 1900s on its effectiveness; it did not start at that way. The biggest challenge to this discovery was it mass production‚ which later came down the road. This drug was discovered in a very unusual way by Alexander Fleming in 1920. Fleming had returned from a summer vacation and began sorting petri dishes
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