known as “aniline analgesics” (Behera‚S.‚et.al‚ 2012) and is widely used as analgesic and antipyretic drug‚ together with caffeine‚ ibuprofen‚ and diclofenac sodium. Based on the United States Pharmacopeial Convention‚ Titrimetric‚ Thin Layer Chromatographic Identification Test‚ as well as UV spectrophotometric assay determinations have been suggested as determination methods for Paracetamol in tablet formations. For Paracetamol‚ various methods have been made known in its determination in bulk
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for simultaneous assay of Ritonavir and Lopinavir was validated according to ICH guidelines with respect to system suitability‚ linearity‚ sensitivity‚ accuracy‚ precision and robustness. 3.3.3 System suitability Before sample analysis‚ the chromatographic parameters used in this analysis must conform the system suitability parameters within the limits. The retention time (Rt)‚ tailing factor (T) and theoretical plate number (N) for the principal peak and its degradation product were evaluated for
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Abstract: The persistence of Propaquizafop was studied in two different soils (Canning-saline soil and Jhargram-red & lateritic soil) under controlled laboratory simulated conditions. Propaquizafop was fortified at 2 and 4 µg g-1 and samples were drawn‚ extracted and analyzed upto 90 days at regular intervals. Dissipation of Propaquizafop was followed first order kinetics irrespective of any treatment and soil type. Calculated half-life values were found to be in the range of 25.29-27.63 days irrespective
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Lack of bioequivalence between disulfiram formulations Exemplified by a tablet/effervescent tablet study Andersen‚ M. P. Lack of bioequivalence between disulfiram formulations. Acta Psychiatr Scand 1992: 86: 31-35. M. P. Andersen Pharmacokinetic Laboratory AIS Dumex (Dumex Ltd.)‚ DK-2300 Copenhagen Abstract - A comparison of the bioavailability of disulfiram (DSF) after administration of non-effervescent Antabusea tablets (CP Pharmaceuticals‚ UK) and Antabuse@effervescent tablets Antabus@(A/S
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Metabolism Figure 1 above is adapted from João M‚ et al (2012) the chromatographic methodologies for analysis of cocaine and its metabolites which‚ shows the metabolic pathway of cocaine administrated. Cocaine is largely metabolized into two major metabolites benzoylecgonine (BE) and ecgonine methyl ester (EME) and two minor metabolites norcocaine (NCOC) and m- and p-hydroxycocaine (OH-COC) (Goldstein et al.‚ 2009). Benzoylecgonine is primarily produce in the liver by human carbozylerstrase type
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Introduction In an E1 reaction‚ where E stands for elimination and 1 stands for unimolecular. The breaking of the C-LV bond is completed before any reaction occurs between the base to lose a hydrogen and form the carbon-carbon double bond [1]. When the more substituted alkene is the dominant product‚ the reaction follows Zaitsev’s rule. Zaitsev’s rule states that the major product of a β-elimination reaction is the most stable alkene [1].Acid-Catalyzed Dehydration is the elimination of a
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|Pharmacy | |Sr. No. |Core Areas |Percentage | |1. |Pharmaceutics |20% | |2. |Pharmaceutical Chemistry
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1.5.2.5 Detectors The detectors used in UPLC should be able to handle very fast scanning methods because half-height peak widths of less than one second are usually obtained with columns packed with 1.7 µm particles. The detector must be able to give high sampling rate adequate to capture enough data points across the peak for an accurate and reproducible integration of analyte peak. The dispersion (volume) of the detector flow cell must be minimal to maintain separation efficiency. Conceptually
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racial group Define Assimilation When youre a member of a minority group‚ and you want to be accepted into a majority group Define Pluralism Several races live within close proximity and get along Segregation A physical seperation of two races; De Facto-People voluntarily choose to live segregated; De Jure- Segregation based on laws Domination When a majority group assumes power‚ and takes over Expulsion When the majority group attempts to get rid of
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The Great Depression was the longest and worst economic downturn in the history of the world’s economy. The depression began in the time of 1929 and lasted until 1939. It pronounced the beginning of the involvement from the government to the countries society and also the economy. This economic downturn affected Western industrialized economies but its effects spread across other nations. The Depression began in the United States‚ which experienced its worst effects. Even so‚ some argue that The
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