International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human use (ICH) was established. Then‚ in late 80is‚ RS were classified as impurities. Categories of residual solvents were presented in the preceding paper. The ICH Harmonized Guidelines set up by the EU‚ Japan and USA for the registration of pharmaceutical products require‚ under ICH Topic Q3C (published in December 1997)‚ for testing to be performed for residual solvents when production or purification
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Kayla Adkins Forensic Chemistry Exam 2 I have been honest and observed no dishonesty. 1. In specific detail‚ describe a published procedure for the definitive identification of Heroin utilizing gas chromatography-mass spectroscopy (GCMS). Heroin is a white crystalline powder with no odor and a bitter taste. It is a derivative of morphine in that the –OH (hydroxyl group) is replaced by an acetyl group‚ -OCOCH3 and has a molecular formula is C21H23NO5 with a molecular weight of 369.42
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Residual solvents Identification and control of the residual solvents (USP 32(467)‚ page 181 Determination by gas chromatography with mass detector and headspace sampler Conditions of the chromatograph Agilent 7890A (LCTG CGMS): * Column DB-624 30m 0.25 mm 1.4µ (CG-2) * Injector temperatura: 160ºC * Flux: 1.0 ml/min * Split: 5:1 * Carrier gas: Helium * Time per test: 30.6 min Conditions of the detector 5975C inert MSD * Data adquisition mode: Scan/SIM * Mass:
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on physical properties. Paper chromatography will be used to separate the dye colors from M&M candy to see which colors contain yellow #5. Gravimetric separation will be used to separate salt and sand from a mixture. Procedure The procedure for this lab can be found on pages 16 – 30 in “General Chemistry CHE110L Laboratory Manual Fall 2013”. Data Tables Carbon copies of data tables have been attached to the back of this lap report. Calculations Paper Chromatography- 1. Yellow M&M’s Rf Value:
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use Gas Chromatography to distinguish between two enantiomers of carvone from caraway oil and spearment oil and to find the 2 carvone’s optical activity as well as percent carvone in spearment and caraway oil. It was found that S-carvone had an optical activity of 0.0047 and R-carvone had an optical activity of 0.516 and that spearment oil is 59% carvone and caraway oil is 100% carvone. Backround: Gas Chromatography separates organic samples much in the same way as column chromatography. The only
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China’s demand for coated paper has grown at a fast pace in the past decade. In the next five years‚ both production and demand will continue to grow. Coated Paper Markets in China examines China’s economic trends‚ investment environment‚ industry development‚ supply and demand‚ industry capacity‚ industry structure‚ marketing channels and major industry participants. Historical data (2003‚ 2008 and 2013) and long-term forecasts through 2018 and 2023 are presented. Major producers in China are profiled
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Chromatography Lab Questions Pre-Lab Questions 1. A pencil is used rather than a pen to mark the “starting line” in step two because a pen or marker while be used to place a small dot of ink in the center of the X that is made with a pencil. 2. Capillary action is filling of pores in a solid with a liquid. Capillary action is caused by spotting or absorption and is allowed to seep or flow through. 3. The type of pen that will probably give better separation in this paper chromatography
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Ion Exchange Chromatography Week 10 TAG Question 1: Chapter 6-4 of your technique book provides a detailed description of how to run a ion- exchange column. Assume you have a cation-exchange column already prepared and ready to use. Create an outline of no more than 10 steps describing how you will regenerate the column‚ load your sample and collect the hydronium ion released. 1. Open the stopcock at the bottom of the column and allow solution to drain out until the solution level in the
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“Which kitchen paper is the best at absorbing liquid?” Scientific Principles- Since paper towels are used to pick up liquids‚ the volume of liquid it can hold is important. The amount of liquid a towel can absorb can be measured by the volume of liquid it picks up. Aim- To investigate which kitchen paper is the best at absorbing most liquid. Hypothesis- I think that Viva/Kleenex will be the best at absorbing most of the liquid because I think it’s the thickest paper towel and I think that it can
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Name _____________________________ Date ____________ Period _______ Completing the Square Day 1 For each expression‚ find the number you would add to make it a perfect square trinomial. Leave fraction answers as improper fractions (no mixed numbers or decimals). Then factor each trinomial. 1. x2 + 10x + _______ 2. y2 – 6y + ¬¬¬¬_______ 3. z2 – 8z + _______ _____________________ _____________________ _____________________ 4. x2 + 12x + _______ 5. x2 – x + _______ 6.
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