aspirin Intro- Aspirin is known as a pain reliever for muscle ache‚ head ache and can prevent heart attacks as well as blood clots‚ and many more things that it can help with. Aspirin is known as Acetylsalicylic acid (ASA) is a Salicylate. Salicylates are organic acids from plants that people for hundreds of years have been used for pain reducing. Salicylic acid irritates the stomach when consumed so German scientist Felix Hoffman suggested ASA as an alternative. Aspirin is made when Acetic Anhydride
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SYNTHESIS OF THE PHARMACEUTICAL ASPIRIN (ACETYLSALICYLIC ACID) AIM: The aim for this experiment was to synthesise a small amount of aspirin with salicylic acid as the starting product and sulphuric acid as the catalyst. The product obtained from this reaction will be impure and will need to be purified. This will be done by recrystallization. We will then record the products’ melting point and calculate the yield in order to determine the degree of purity of the aspirin sample. Diagrammatic scheme
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crystals 95% ethanol Clear colorless liquid Acetyl chloride Clear colorless liquid with gas escaping from container FeCl3 Clear colorless liquid Commercial aspirin Fine powdery white solid crystals I2/KI Deep black liquid KMnO4 Brownish liquid Phosphoric acid Clear colorless liquid Table 2. Preparation of Aspirin. Description Salicylic acid + Acetyl chloride Cloudy white liquid with undissolved white powder Mixture at room temp White cloudy liquid Mixture in ice bath
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Abstract For the amount of aspirin in a commercial tablet to be determined‚ different solutions of acetylsalicylic acid mixed with NaOH were created at different concentrations. All the different solutions were then analysed using Novaspec photometer‚ which allowed for a graph to be created and a line of best fit to be made. The amount of aspirin in a commercial tablet was found to be 350mg. Introduction The molecular formula for aspirin‚ also known as acetylsalicylic acid‚ is C9H8O4. It is most
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Aspirin were used to relieve pain‚ inflammation‚ and fever. Aspirin were made using a combination of salicylic acid and acetic anhydride.The goal of this experiment was to determined the purity of aspirin using different methods. These methods included‚ reacting salicylic acid with FeCl3‚ finding its melting points‚ and by doing Thin-layer chromatography. When you reacted salicylic acid with FeCl3‚ changes in color will occur. Pure Aspirin has a melting point around 135°C and a pure salicylic acid
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Experimental Synthesis of Aspirin and Melting Point Purity Analysis Donald Yeargin CH 222‚ Section 24221 Department of Chemistry Portland Community College Portland‚ OR Abstract The various methods available to synthesize aspirin lead to the need to examine and evaluate production efficiency and purity. The purpose of our experiment was to synthesize acetyl salicylic acid (aspirin) and then determine the relative purity of the synthesized sample by observing the melting point temperature
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Safety Precautions for Synthesis of Acetic Anhydride Acetic Anhydride Acetic anhydride is an irritant and also flammable‚ therefore gloves and goggles should be worn at all times during the experiment. It is reactive to water‚ so in the case of fire‚ alcohol foam or carbon dioxide is preferred to use as an extinguisher. This chemical has harmful fumes and use of a fume hood is strongly recommended. Sulphuric and Salicylic Acid These acids may irritate the skin in high concentrations. Take
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CH4300/PY5140 - EXPERIMENT 2 – Answer Sheet SYNTHESIS OF THE PHARMACEUTICAL ASPIRIN (ACETYLSALICYLIC ACID) Aim: The aim of this experiment was to react salicylic acid with ethanoic anhydride to produce Aspirin. CH3CO)2O + HOC6H4COOH → CH3CO2C6H4CO2H + CH3COOH i Mass: 5g Volume: 7.5 cm3 Mass: 6.52g RMM: 138g/mol RMM: 180g/mol Moles: 5/138 = 0.0362 RMM: 102g/mol Moles: 0.0362 OBSERVATIONS – First‚ Ethanoic acid was added to the salicylic acid which resulted
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Commercial Aspirin Tablet Analysis Tuesday Evening Intro: The purpose of this lab was to analyze commercial aspirin tablets. To do so‚ the percent acetylsalicyclic acid (active ingredient) in tablets using acid-base titration was determined‚ the percent acetylsalicyclic acid in tablets by formation of a colored iron(III)-salicylate complex was determined using spectrometry‚ and then the percents from each process was compared. Acetylsalicylic acid is produced when salicylic acid and acetic
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FOUNDATION IN SCIENCE INTRODUCTION TO PRACTICAL ORGANIC CHEMISTRY – MAKING AND PURIFYING ORGANIC COMPOUNDS Stage 1 – Deciding how much reagent to use Most organic reactions do not go to completion; most reach an equilibrium position with significant quantities of reactants still remaining. In addition‚ separating the desired product from the rest of the reaction mixture‚ and then purifying it‚ will result in the loss of more of the product. The amount of product obtained expressed as a percentage
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