2-((6‚8-dibromo-2-(4-chlorophenyl)quinazolin-4-yloxy)methyl)-5-methyl-1‚3‚4-oxadiazole (IX) : A mixture of the hydrazide VII (0.01 mol) and acetic anhydride (30mL) was refluxed for 6h. The precipitated solid formed upon cooling‚ was filtered and recrystallized from ethanol‚ m.p. 155oC‚ 80% yield. Analysis calculated for C18H11Br2ClN4O2; Calcd.: %C‚ 42.34; H‚ 2.17; N‚ 10.97‚ Found: % C‚ 42.30; H‚ 2.14; N‚ 10.90. IR: υmax./cm-1 3000 (C-H aromatic)‚ 1610 (C=N) and at 1600 (C=C). 1H-NMR (DMSO-d6‚ ppm):
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Daclizumab (Biogen Idec and Abbott Biotherapeutics Corp.) is a humanized mAb acting as a blocker of the α-subunit (CD25) of the high-affinity IL-2 receptor [19]. IL-2 is secreted by activated lymphocytes and stimulates production of other proinflammatory cytokines while it is also involved in lymphocytic proliferation. Daclizumab was initially approved for the prevention of renal allograft rejection as part of a combination regimen and evidence was progressively accumulated showing that this drug
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mutations going‚ to avoid inflammatory response (caused by cells that exploded/necrosis).. ect. Necrosis is triggered by something unplanned‚ leading to decrease ATP‚ pumps‚ atpase activity‚ membrane becomes permeable = lysis‚ Caused by trauma or cytotoxicity. Now all of these organelles and enzymes ect are in the neighboring cells which cause problems to healthy cells. By apoptosis you can get rid of cell without impact on neighbouring
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Synthesis‚ characterization‚ crystallographic Study and antibacterial activity of sodium butyldithiocarbamate pentahydrate‚ C5H20NNaO5S2 Ayodele T. Odularu a‚ Peter A. Ajibade a‚ Bolhuis‚ A. b a. Department of Chemistry‚ University of Fort Hare‚ Private Bag X1314‚ Alice 5700‚ South Africa. b. Department of Pharmacy and Pharmacology‚ University of Bath‚ United Kingdom. Abstract Synthesis of sodium butyldithiocarbamate pentahydrate‚ C5H20NNaO5S2‚ entailed a one-pot synthesis. The process of synthesis
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Cain‚ M.L.‚ Wasserman‚ S.A.‚ Minorsky‚ P.V.‚ Jackson‚ R.B. 2008. Biology‚ 8th ed. Pearson Benjamin Cummings‚ San Francisco CA‚ pp. 125-138. Repetto‚ G.‚ del Peso‚ A.‚ LZurita‚ J.2008. Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nature Protocols. 3: 1125 - 1131. Rikhvanov‚ E.G.‚ Varakina‚ N.N.‚ Rusaleva‚ T.M.‚ Rachenko‚ E.I.‚ Voinkov‚ V.K. 2002. The effects of sodium azide on the thermotolerance of the yeasts Saccharomyces cerevisiae and Candida albicans. Microbiology
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Hashimoto Thyroiditis I did not know too much about Hashimoto thyroiditis and I wanted to learn about something that I didn’t know a whole lot about. I knew basic things like patients have to take their medication‚ see their doctor‚ and if a female patient gets pregnant to see their doctor immediately. Hashimoto’s disease is a disease known by many names. They are chronic lymphocytic thyroiditis‚ Hashimoto thyroiditis‚ and autoimmune thyroiditis. It was first discovered by a scientist named Hakaru
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Identification and characterization of Pierisin gene in P. napi The strategy was followed to amplify the Pierisin-6 gene was given in the supplementary Fig. 1. The mRNA of pierisin-6 gene was purified from the total RNA of fifth instar larvae of P. napi‚ the conserved region was amplified using gene specific primers (supplementary table-1)‚ cloned into pGEM®-T vector and sequenced. Further‚ 3’ and 5’ untranslated regions of pierisin-6 gene were identified by 3’/5’ RACE-PCR. The amplified cDNA sequence
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Abstract: Cajanus cajan (L.) is one of the Pigeon pea cultivated in tropical and subtropical areas. It contains many fractions characterized by their bioactivity and efficacy to enhance biological activities. The aim of the present study was to fingerprinting the Cajanus cajan plant ‚ then extract the flavonoids fraction (FFCC) with methanol extract‚ and assess the antimutagenic efficacy of the fraction extract to reduce genotoxicity induced by cyclophosphamide (CP) using chromosome aberrations‚
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Method • Methodology is performed through 3 successive days: First Day: Trypan Blue cell viability assay: Description Trypan blue staining is a simple way to evaluate cell membrane integrity (and thus assume cell proliferation or death) but the method is not sensitive and cannot be adapted for high through put screening. Short 96 well assay: EACH condition should be done in triplicate or more. Steps 1. Trypsinize one T-25 flask and add 5 ml of complete media to trypsinized cells. Centrifuge
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This paper is the first to indicate antiemetic activity of the methanolic extract compositions of A. julibrissin flowers and its protective effect on mitochondria disruption induced by retching in brain of the young chickens. Nausea and vomiting are the symptoms of drug side effects‚ different disease and defenses responsive against poisoning. Recently‚ extensive researches have led to use of medicinal plants as a safe and reliable source of drugs with low or lack of toxicity and side effects [22
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