Metallobiomolecules METALLOBIOMOLECULES CONTENTS 1. Introduction Metallobiomolecules 2. Classification Metallobiomolecules 2.1. Transport and of to Storage Proteins 2.2. Oxygen binding Today scientists try to explore the chemistry basis behind the biological processes. As a result of this‚ new areas have evolved such as bioinorganic chemistry and bioorganic chemistry. In this section we will talk about an important concept in bioinorganic chemistry called “Metallobiomolecules”. Metallobiomolecules
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dissolved O2 (1.5%) b. 98.5 % – bound to Hemoglobin (iron in Heme group) 2. Hemoglobin saturation a. 4 O2 = 100% b. 2 O2 = 50% c. Hb binds O2 reversibly B. Oxygen-Hemoglobin dissociation curve 1. Relates saturation of Hb with pO2 increase Hb saturation ( ↑ affinity)2. increase pO2 —— a. Hb stores O2 decrease Hb saturation (↓affinity)3. decrease pO2 —– a. Hb releases O2 4. Normal tissue 75% (pO2 = 40 mmHg)a. 97% (pO2 = 95 mmHg) —– b. Venous blood has large O2 reserve 5. Active tissue
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nitrogens from tetrapyrrole ring system ii. 5th bond - Helix F binds to Fe at terminal Histidine th * 5 bond = helix F8‚ residue 93 in Mb‚ molecule (His F8)* = proximal histidine residue 92 in the β-chain of Hb and iii. 6th bond – deoxygenated: empty‚ histidine residue from residue 87 in α-chain of Hb th helix E** hovers; oxygenated: oxygen bonds here ** 6 bond = helix E7‚ His 64 for Mb‚ His 63 in b-chain and 58 in a-chain c. Oxygen binds to Fe at 120° angle easily removed II. MYOGLOBIN A. Physico-chemical
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PACE UNIVERSITY Managing Innovation MBA-678 - Fall 2014 Section(s) CRN 71670 (lecture)‚ - Tuesdays 5:40-8:30PM Classroom(s): PNY W-522 Professor: John C. Byrne‚ Ph.D. Office: W491 (PNY). Pace Phone: 212-618-6581 Office Hours: Home Phone: 201-722-1459 – BEST ! Tue.: – 02:30-5:00pm – PNY e-mail: jbyrne@pace.edu – BEST ! Wed: – 02:30-5:00pm – GC Due to having to visit multiple campuses and the usual sundry meetings‚ etc.‚ it would be best to send me a note with a request
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66 GfK MIR / Vol. 4‚ No. 2‚ 2012 / Case Study { Summary } Jetstar Airways HOW MODELING GUIDED THE BRAND MIGRATION STRATEGY OF A LOW COST CARRIER John Roberts‚ Peter Danaher‚ Ken Roberts‚ and Alan Simpson Turn to page … 42 ... to read the full article This article describes the application of a dynamic choice model of consumer preferences. It supported Jetstar‚ a subsidiary of Australia’s leading airline‚ QANTAS‚ to effectively and profitably compete in the low cost carrier marketplace
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reversibly to Hb‚ however‚ due to the greater affinity of CO as compared to O2‚ CO not readily displaced at normal O2 concentrations: it does not spontaneously displaced from Hb but is displaced by mass action of O2. CO level in blood is represented as the percentage of Hb in the form of carboxyhemoglobin (COHb) which is a Hb-CO complex. Human body have 0.1-1.0% (Mercury‚ 1990)‚ 0.4-0.7% (Widdop‚ 2002) endogenous COHb saturation produced through the process of natural degradation of Hb. The rate of
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Project Report: Corporate Overview: HB InfoTech (HB) is a global IT company. HB offers clients business solutions that leverage all aspects of the software life cycle. These span consulting‚ design‚ development‚ re-engineering‚ maintenance‚ systems integration‚ and package evaluation and implementation. HB also offers software solutions aimed specifically at the banking industry. HB leverages its global client base and its professional workforce through its Global Delivery Model. The company
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Cited: Gourville‚ J (1998)‚ Biopure Corporation‚ HBS‚ p.10 – 11 Gourville‚ J (1998)‚ Biopure Corporation‚ HBS‚ p.11 Gourville‚ J (1998)‚ Biopure Corporation‚ HBS‚ p.8 Gourville‚ J (1998)‚ Biopure Corporation‚ HBS‚ p.2
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justified by a state’s interest in promoting health as well as by medical evidence backing the necessity of the law. Hellerstedt claims that Fifth Circuit was right in not considering the state’s interest and how it balances with the regulations of HB 2 (Shimabukuro 2016). Utilizing the balance between states’ interest and severity of the regulation is what the Supreme Court has to do to protect Casey’s intentions of preserving Roe. The court that decided Casey intended to balance the states’ interest
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H2O‚ and most of it is carried by Hb in the RBC’s. The interaction of iron ions with O2 binds O2 to the Hb‚ forming ‘oxyhaemoglobin’‚ (HbO2). This happens when the pressure (concentration) of O2 is very high for example‚ in the lungs. Each Hb can bind four O2 (one molecule per haem). The reverse occurs in the body cells‚ where O2 pressure (concentration) is low: increase in oxygen concentration Hb + O2
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