The WB-PBPK model for caspofungin was constructed according to the scheme of 14 tissue compartments of the disposition model. Simulations were based on caspofungin physicochemical and the vitro data (Table 2). Tissue distribution was predicted using established tissue composition equations. Hepatic and renal caspofungin clearances were calculated by the PKplus model‚ as described in the method section. The results are shown in Table 3. The observed and WB-PBPK model simulated mean plasma concentration-time
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of Egan’s Helping Model‚ rather vague. Perhaps a lesson articulating assumptions overall and applying this information to the Model would have been very helpful. The Model seems straightforward initially but the application of the sections and stages at this point seem overlapping and confusing. One needs to drill much deeper in order to academically critique the Model. After studying the Model in chapter two‚ my three underlying assumptions that Egan states to make the Model work is: (i) that
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PROS AND CONS OF THE GROW COACHING MODEL The GROW Model Goal – Reality – Way to Go – Options Introduction The GROW coaching model is a tried and tested model to structure coaching lessons. The power GROW is that It leads to a clearly defined and result through 4 phases. The coachee is personally active in identifying problems and generating ideas for solutions. That means that anything that out of the coaching sessions has a lot of chance to work. The GROW stands for learning through experience:
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Management Assignment Implication of McKinesy’s 7s model. The McKinsey 7S Framework _The Mckinsey 7s model ensures that all parts of the organization are in harmony. The 7s model consists of seven elements_ The Seven Elements The McKinsey 7S model involves seven interdependent factors which are categorized as either "hard" or "soft" elements: "Hard" elements are easier to define or identify and management can directly influence them: These are strategy statements; organization charts and reporting
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How are you? I recently have two-week period of probation in Đa Lat. Do you know Da Lat city? Why did I go to Da Lat? Because Da Lat has Nuclear Research Reactor. In this trip‚ I had the opportunity to see Da Lat city and Da Lat is very beautiful‚ very nice. Dalat is a “miniature Paris” in the tropics that attracted visitors with wonderful landscapes and historical relics. Dalat is most impressive as a city of flowers. When I came to Da Lat‚ the first day I walk around Xuan Huong Lake and sightseeing
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Matt Bishop Drawing/ Painting Ms. Mezzetti 2/17/2013 If you know anything about art I am positive you have heard of Leonardo Da Vinci. Today‚ Da Vinci is considered one of the most famous artists of all time. His work is phenomenal. He is known for his paintings‚ sculptors‚ architect work. Besides this he was a musician‚ mathematician‚ engineer‚ inventor‚ anatomist‚ geologist‚ cartographer‚ botanist‚ and a writer. For my project I selected to use the Mona
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Leonardo Da Vinci’s Mona Lisa Mona Lisa or La Giaconda it is probably one of the most well known works of art in the world. It is one of the most copied‚ photographed‚ and reprinted works of art. I myself have her as a screensaver in my laptop. Throughout the years‚ there have been all types of theories about her in the Mona Lisa painting. It seems that most of these theorizers not only have a hypothesis about her smile or name‚ but believe that no one else’s hypothesis is right except for theirs
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Information ■ Birth name: Leonardo di ser Piero da Vinci ■ Born: April 15‚ 1452 (Vinci‚ Republic of Florence present-day Italy) ■ Died May 2‚ 1519 (Age 67 Amboise‚ Kingdom of France) ■ Nationality: Italian ■ Leonardo di ser Piero da Vinci was an Italian Renaissance polymath: painter‚ sculptor‚ architect‚ musician‚ scientist‚ mathematician‚ engineer‚ inventor‚ anatomist‚ geologist‚ cartographer‚ botanist‚ and writer. ■ Leonardo da Vinci was the love child of a landowner and
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History 101 | Leonardo Da Vinci | Renaissance Pioneer | | Luis Quelhas | 11/13/2012 | | Leonardo Da Vinci was born on April 15‚ 1452. His father was a wealthy notary‚ named Piero Fruosino di Antonio da Vinci. His mother Caterina was a sixteen year old peasant girl. Leonardo had no surname when born and took the name Da Vinci meaning from Vinci‚ the small town in Florence where he was born. Throughout his life Leonardo faced many hardships. From 1457 he lived in the household of
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Leonardo Da Vinci Leonardo da Vinci (1452-1519) was a painter‚ architect‚ inventor‚ and a scientific student. He was such a natural genius that he embodied the term “Renaissance man.” Today he is best known for his art‚ including two paintings that are the world’s most famous and admired‚ Mona Lisa and The Last Supper. Using a technique called "hatching"‚ he worked by sketching in series of short‚ quickly-drawn parallel lines. He also developed various personal drawing tricks‚ including curved
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