INTRODUCTION A major obstacle in the successful treatment of cancer is the development of resistance mechanisms to drug treatment. Various cellular changes that have been implicated in the development of drug resistance in cancer cells include: the increased expressions of P-glycoprotein (a multidrug transport protein) and multidrug resistance-associated protein (MRP-1); increased levels of the cellular detoxification protein‚ glutathione; and changes in the expression of apoptosis associated
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Minister Ghulam Mohammad was named the new Governor General. Ghulam Mohammad was not a politician. He revived the Jinnah’s style of functioning and operated through the civil servants. He brought Maj. Gen. lskander Mirza into the government as the Defence Secretary. Mirza was not a fighting General. He belonged to the British Political Service and had spent most of his career in the Frontier quelling Pathan insurgency. It was also the time when General Ayub Khan became the first Pakistani Chief of
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Sample Technical Writing Mechanism Description Audience and use profile This Document is designed for entrepreneurs who want a portable computer‚ but students may also take interest‚ because some of their needs are similar to those of business people. Also‚ the purpose of the description is to inform the audience by providing a comprehensive informative document on how this particular mechanism works‚ and the description is also designed to provide information on its usefulness. Furthermore
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Mobile Care System With Alert Mechanism Ren-Guey Lee‚ Member‚ IEEE‚ Kuei-Chien Chen‚ Chun-Chieh Hsiao‚ and Chwan-Lu Tseng Abstract—Hypertension and arrhythmia are chronic diseases‚ which can be effectively prevented and controlled only if the physiological parameters of the patient are constantly monitored‚ along with the full support of the health education and professional medical care. In this paper‚ a role-based intelligent mobile care system with alert mechanism in chronic care environment is
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STRESS COPING MECHANISMS AMONG YOUTH (PGDM STUDENTS) 1. INTRODUCTION A word which we consistently heard and feared from the day we thought of doing management studies is “STRESS”. Management studies have been perceived as a hectic and stressful course from the inception of the same. Every individual has his own methods for coping up with the stress; like playing games‚ working out in gym‚ listening to music‚ doing yoga‚ chatting with friends etc.
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Santhosh Varadarajan Mekanism: Engineering Viral Marketing June 30th‚ 2014 In early 2011‚ Jason Harris‚ Mekanism’s president‚ and Pete Caban‚ CEO were considering converting Mekanism from a specialized‚ niche production company‚ to a full-service ad agency. At the time‚ Mekanism was a digital social media production company that developed viral marketing campaigns for various firms. They had great success seeing 68% annual growth in billings which was fasted than they had predicted. In 2010
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Introduction A can opener is a kitchen utensil used to open canned goods. A manual can opener has four parts: the handles‚ the crank‚ the traction gear‚ and the cutting wheel. These parts are found only on a manual can opener. Handles The body of a manual can opener consists of two handles connected with a single bolt‚ allowing them to be pulled apart and pushed together. Higher-quality can openers have rubber grips on the handles‚ making them easier and more comfortable to grip. Traction Gear
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1a. Two reasons that the mass of the bag levels off with time include (1) equilibrium and (2) hydrostatic pressure. Equilibrium refers to the concentrations becoming equal. If there is no longer a higher concentration and lower concentration between the water and sucrose‚ osmosis can no longer take place. Osmosis can only occur when water is traveling from a higher concentrated area to a lower concentrated area. Hydrostatic pressure occurs when the bag reaches maximum capacity. Water will enter the
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Basic Mechanism An autoimmune disease occurs when the body produces an abnormal immune response against self antigens. It is caused by failure of the tolerance processes to protect the host from the action of self reactive lymphocytes. An organ-specific autoimmune disease involves gradual damage to cellular structures and is replaced by the compensating connective tissue which depletes the function of the gland/organ. Type 1 diabetes (TD1)‚ is an organ specific autoimmune disease characterize
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There are four mechanisms of unfreezing stage. Disconfirmation ; information disproves the assumptions and makes need for change obvious. Looking at the current situation and seeing it is not satisfying. People feel frustration and dissatisfaction. Nurses don’t use translators efficiently and having hard times with assessing patients. This is just unacceptable. Lack of confirmation; no information forthcoming to validate assumptions- it dawns on person slowly that the change is needed. Nurses still
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