Evolutionary Optimization of Protein Folding ´ ` ´ ¨ Cedric Debes1‚ Minglei Wang2‚ Gustavo Caetano-Anolles2*‚ Frauke Grater1‚3* 1 Heidelberg Institute for Theoretical Studies‚ Heidelberg‚ Germany‚ 2 Evolutionary Bioinformatics Laboratory‚ Department of Crop Sciences‚ University of Illinois‚ Urbana‚ Illinois‚ United States of America‚ 3 CAS-MPG Partner Institute and Key Laboratory for Computational Biology‚ Shanghai‚ China Abstract Nature has shaped the make up of proteins since their appearance
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SWOT Strengths ColgateColgate-Palmolive is recognized as the world’s leader in personal care sales which included oral hygiene products like toothbrushes and toothpastes. In 1991‚ its sales topped at $6 billion and profits at $2.76 billionand as it cornered 43% of the world’s toothpaste market and 16% of the world’s toothbrush market. In the United States‚ the world’s largest market‚ ColgateColgate-Palmolive holds the number one spot in toothbrush sales with a market share of 23%. From these
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FACTORSBranding: Should the name of the product on the package and in advertising be "Colgate Precision" or as "Precision by Colgate"Communication and promotion: This is an effective way to pull a market share because it is hard to increase primary demand unless stealing sales from existing productsMajor competitors in the super-premium segment: Oral-B‚ Reach Advance Design‚ Crest Complete‚ and Aquafresh FlexDifferential pricing structure: Niche market vs. Mainstream marketDifferent advantages/ disadvantages:
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1. CP company should launch Precision as a niche product for the below 2 reasons. 1) Not all of the customers are willing to pay high price for the best toothbrush for their oral hygiene‚ which is the main objective of the Precision (refer to Exhibit 1). 2) CP is already no.1 volume in the tooth brush market so the Precision should avoid the cannibalization for their existing main-stream products in both the value segment and the professional segment and should compete with Oral-B for their
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Executive Summary Precision Worldwide‚Inc (PWI) is a manufacturing company of industrial machines and equipment for almost 90 years. One of their plants located in Frankfurt‚ Germany‚ produces a particular model at a price ranging from $ 18‚900 to $ 28‚900. Moreover‚ the plant has another department that manufactures steel retaining rings. These rings are considered as an integrate parts of the machines they are actually manufactured. This department can sell their rings either internally or externally
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Accuracy and Precision Laura Norwood CHM/110 October 11‚ 2012 Dr. Grant W.Wangila Accuracy and Precision Chemistry is a vibrant part of society. When experiencing some of life’s simplest of pleasures‚ there is usually a process that has undergone different aspects of what a chemist studies every day. In the text for this course‚ the example of experiencing even a simple sunset can be related to chemistry. “Molecules in the air interact with light from the sun‚ scattering away the blue
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Chemistry and Society Paper In everyday life‚ accuracy and precision are important. These two terms are often interchanged freely‚ but these terms have key differences. Many businesses require both accurate and precise measurements to stay in business. Accuracy and Precision Accuracy refers to something that is consistent with a known value (Maze-Emery‚ 2009). Precision is the amount of detail something provides (“accuracy/precision‚” 2005). A simple analogy is someone throwing darts at a dartboard
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Precision Worldwide‚ Inc. RECOMMENDATION: Sell the steel rings to the current customers in the French market and inform them that the company has discovered another innovative technique that will decrease their cost and increase the wear time on the rings. Also explain that you are testing the product in other markets to determine if it is a superior product worth their time. Once the steel rings have been exhausted introduce the plastic rings. Utilize the excess labor to produce the steels rings
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Precision Worldwide‚ Inc. Case Study Case Study Background: Precision Worldwide‚ Inc. (PWI) manufactures industrial machines and equipment for sale in numerous countries. Repair and replacement parts account for a substantial part of the company’s business. The replacement part in question‚ steel rings‚ occur in the machines manufactured only in PWI’s Frankfurt Germany plant‚ but can also be used on some competitor’s machines. The steel ring manufactured by PWI has an average normal life of about
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numbers are stored in memory An IEEE-754 float (4 bytes) or double (8 bytes) has three components (there is also an analogous 96-bit extended-precision format under IEEE-854): a sign bit telling whether the number is positive or negative‚ an exponent giving its order of magnitude‚ and a mantissa specifying the actual digits of the number. Using single-precision floats as an example‚ here is the bit layout: seeeeeeeemmmmmmmmmmmmmmmmmmmmmmm meaning 31
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