INTRODUCTION A major obstacle in the successful treatment of cancer is the development of resistance mechanisms to drug treatment. Various cellular changes that have been implicated in the development of drug resistance in cancer cells include: the increased expressions of P-glycoprotein (a multidrug transport protein) and multidrug resistance-associated protein (MRP-1); increased levels of the cellular detoxification protein‚ glutathione; and changes in the expression of apoptosis associated
Premium Apoptosis Oncology Cancer
BUSINESS RESEARCH METHODOLOGY BOARD EFFECTIVENESS AND COST OF DEBT by : FARUQ AKURAT 100810251004 ECONOMIC FACULTY JEMBER UNIVERSITY 2011 / 2012 Board Effectiveness and Cost of Debt ABSTRACT Does the board of directors influence cost of debt financing? This study of a sample of Spanish listed companies during the period 2004–2007 provides some evidence about the question. The results suggest that two board attributes – director ownership and board activity – appear to influence
Premium Corporate governance Board of directors Management
STRESS COPING MECHANISMS AMONG YOUTH (PGDM STUDENTS) 1. INTRODUCTION A word which we consistently heard and feared from the day we thought of doing management studies is “STRESS”. Management studies have been perceived as a hectic and stressful course from the inception of the same. Every individual has his own methods for coping up with the stress; like playing games‚ working out in gym‚ listening to music‚ doing yoga‚ chatting with friends etc.
Premium Stress Cortisol Factor analysis
This report is written to investigate the effectiveness of organ sales in a society which has included a number of issues such as organ trafficking as well as abduction towards the society for both developed and developing countries. Back in the olden days‚ researchers have been conducting numerous experiment of transferring an organ to replace a failure organ from one body to another which‚ by today‚ is known as an organ transplant. They have conducted these experiments way back in the mid 18th
Premium Organ transplant Organ Organ donation
Chapter 5: Internal Control over Financial Reporting 1. Internal control is a process designed to guarantee the achievement of the objectives of reliable financial reporting‚ compliance with laws and regulations and ineffective and inefficient operations. FALSE 2. Auditing standards require that the auditor exercise professional judgment and maintain professional skepticism throughout the planning and performance of the audit. TRUE 3. If internal controls are not enforced they are useless
Premium Internal control Auditing Audit
Sample Management Reports on Effectiveness of Internal Control over Financial Reporting Purpose Guidance on the preparation of management’s reports on the effectiveness of internal control over financial reporting is provided by the following. * Item 308(a) of Regulation S-B and S-K‚ 17 C.F.R 228.308(a) and 17 C.F.R. 229.308(a) * Questions 1‚ 2‚ 3‚ and 19 of Internal Control over Financial Reporting and Certification of Disclosure in Exchange Act Periodic Reports: Frequently Asked Questions
Premium
Besides ‘filter mechanisms’‚ there are procedural restrictions that consist of three heads of grounds including illegality‚ procedural impropriety and irrationality. It protects individuals by providing grounds allowing them to seek judicial review and protects the public bodies from interference with their work because individuals must obtain one of the grounds before seeking judicial review. According to Lord Diplock‚ ‘the decision-maker must understand correctly the law that regulates his decision-making
Premium Law Common law Human rights
The Purpose and Effectiveness of Police Patrols To begin studying this topic I’d like to provide a brief definition of a patrol officer. In law enforcement‚ patrol officers are uniformed police officers assigned to patrol specified geographic areas. They are the officers most commonly encountered by the public. Their duties include responding to calls for service‚ making arrests‚ resolving disputes‚ taking crime reports‚ and conducting traffic enforcement‚ and other crime prevention measures. The
Premium Police Crime
The major reason anyone drinks fluid before‚ during and after physical activity is to replace the water that is lost through sweat. If the water isn’t replaced dehydration will occur and performance will be hampered. The purpose of sports drinks is to help rehydrate your body quickly and help improve performance and productivity. This is accomplished through a well-balanced mix of water‚ sugar (carbohydrates) and salts (electrolytes)‚ the major ingredients in most sports drinks. These ingredients
Premium Coffee Electrolyte Exercise
Evaluation of Grievance Handling Mechanism At Reliance Industries Limited Manufacturing Division - Allahabad. IMPACT Evaluation of Grievance Handling Mechanism At Reliance Industries Limited Manufacturing Division - Allahabad. IMPACT Summer Training Project Report On Summer Training Project Report On ●●●●●●●●●●●●●●●●●●●●●●●● ●●●●●●●●●●●●●●●●●●●●●●●● SEPTEMBER‚ 2012 This project focuses on Evaluation of Grievance Handling Mechanism at RIL manufacturing division-Allahabad
Free Reliance Industries Dhirubhai Ambani Mukesh Ambani