resolution of 4 cm-1. Surface topography analysis: The surface topography of the bilayered scaffolds was analyzed using environmental scanning electron microscope (ESEM‚ FEI Quanta 200‚ Netherlands). The scaffolds were fixed on aluminium stubs and the images were acquired at different magnifications. The fiber diameter distribution was quantitatively analyzed from scanning electron micrographs using Image J
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3.5.3 X-Ray Diffractometery (XRD). The crystallinities of pure Zolmitriptan‚ excipients and liquisolid system were evaluated by XRD measurement. It has been seen that polymorphic changes of the drug are important factors‚ which may affect the drug dissolution rate and bioavailability(135). The X- ray diffractogram of pure Zolmitriptan Figure (25) exhibited several sharp peaks at different angle (2Ɵ)‚the three strongest angles were 19.2 Ɵ‚ 21.9 Ɵ and 23.8 Ɵ ‚other angles were 12.2 Ɵ‚13.7 Ɵ‚ 14.2
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solubility there is a need to formulate this curcumin for better bioavailability. Curcumin was extracted by acetone using soxhlet apparatus and evaporated by means of vacuum rotary evaporator. The presence of curcumin was confirmed by differential scanning calorimetry. Nanosuspension was prepared by bottom up method using acetone and water solvent system. Stabilizers were added under optimized conditions in order to achieve suitable quality of nanosuspension. Then it was analyzed using particle size
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amorphous drug systems in different conditions. First‚ three complementary techniques are performed to characterize the crystalline and amorphous form of indomethacin. These techniques include IR spectroscopy‚ Raman spectroscopy and differential scanning calorimetry. Indomethacin is a compound belonging to class II of the BCS and is consequently a poorly water-soluble drug. The limiting step in order to have a good bioavailability is the dissolution step. Several possibilities can be applied to
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Clinically‚ non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently prescribed class of drugs for inflammatory disorders (1). Lornoxicam is a novel NSAID drug. It has an equipotent COX isoenzyme inhibitory effect and subsequently reduces the production of prostaglandins‚ thromboxane‚ and leukotrienes (2). It is prescribed for mild to moderate pain and inflammation in osteoarthritis and rheumatoid arthritis (3). It is prescribed for the treatment of osteoarthritis due to its analgesic
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FIGURE 18 DSC thermograms of fully cured polybenzoxazine composites: (●) heat-cured polybenzoxazine‚ (□) heat-cured 2wt% SiCw‚ (♦) heat-cured 4 wt.% SiCw‚ (▴) heat-cured 6 wt.% SiCw‚ (▾) microwave-cured 4 wt.% SiCw. Reprinted from Ref. [39]. Copyright (2014)‚ with permission from Wiley InterScience. FIGURE 19. SEM micrographs of fracture surface of SiCw-filled polybenzoxazine composites: (a) neat PBZ cured by heat‚ (b) 2 wt.% SiCw -filled PBZ cured by heat‚ (c) 4 wt.% SiCw -filled PBZ cured by
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conditions. After heating a bottle and preform to one-hundred and eighty degrees Celsius‚ the bottle shrank and became opaque on the top and bottom of the bottle. The preform became completely opaque and kept its original size and shape. The Differential Scanning Calorimeter (DSC) provided the heat of crystallization‚ heat of fusion‚ and glass transition temperature for PET bottle samples. The average glass transition temperatures for the top portion of an uncrystallized top and uncrystallized side
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MCOPS‚ Manipal ANALYTICAL METHODS FOR RESIDUAL SOLVENTS INTRODUCTION: Organic solvents are routinely applied during synthesis of drug substances‚ excipients‚ or during drug product formulation. They are not desirable in the final product‚ mainly because of their toxicity‚ their influence on the quality of crystals of the drug substance and their odor or taste‚ which can be unpleasant for patients. To remove them‚ various manufacturing processes or techniques (usually under
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Objective: The Levodopa effervescent floating tablets were prepared using different low density polymers (POLYOX different grades) in various drug polymer ratios for prolongation of gastric residence time and to improve the patience compliance. Methods: The Levodopa effervescent floating tablets were prepared by direct compression method. The floating tablets were evaluated for friability‚ thickness‚ hardness‚ weight variation test‚ drug content‚in vitro release and floating properties. The drug
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generally viewed by ________ spore staining. scanning electron microscopy. Gram staining Negative stain Section: True or False 7. Fluorescent microscopes use an ultraviolet (UV) light source and fluorochromes as stains. True False 8. Older‚ pure cultures of Gram-positive organisms can appear red when Gram stained. True False Section: Matching 9. Which microscope is used to view internal structures of unstained‚ living cells? Scanning electron microscope Dark-field microscopy
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