proposal for the centers of excellence in drug discovery (CEDD)? What are its strengths and weaknesses relative to other potential organizational structures for R&D? Overview: Yamada reorganization of drug discovery at GlaxoSmithKline (GSK) following a merger to combat bureaucracy in decision making‚ approval‚ and authorization. This reorganization was necessary for the continued success of the company. Often the process for drug discovery and market is a slow and tedious process which
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Oncotarget‚ November‚ Vol.1‚ No 7 www.impactjournals.com/oncotarget/ Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Joshua C. Curtin and Matthew V. Lorenzi 1 Oncology Drug Discovery‚ Research and Development‚ Bristol-Myers Squibb‚ Princeton‚ NJ‚ USA Correspondence to: Matthew V. Lorenzi‚ e-mail: Matthew.Lorenzi@bms.com Keywords: oncotarget‚ cancer‚ stem cells‚ wnt‚ drug discovery Received: August 8‚ 2010‚ Accepted: October 27‚ 2010‚ Published: October 30‚ 2010
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In the 1890’s scientist found that invisible rays are emitted when matter is hit with a jolt of electricity. Such experiments involved transmitting electric arcs between two ends of cathode ray tubes. Some physicists discovered some substances that spontaneously emitted invisible rays regardless of electricity or any other type of energy. An example of these substances are: uranium and radium‚ which are named radioactive materials. X-rays were a portion of the emitted rays that had the ability to
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Religion played a big role in shaping the values‚ attitudes‚ and conduct of the Spanish during the Age of Discovery and Conquest (1492-1579). The colonial church provided control and a standard of conduct and living for the new world. In fact‚ the colonial church had even more power in Spanish America then it did in Spain. Why this is important though‚ is because it limited the possibility of rebellion and opposition. As long as the church was in place‚ there was Spanish order‚ and as long as there
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The “Heart of Darkness” is a tale of passage and discovery‚ not only into the heart of Africa‚ but into the heart of our human mind. Written by Joseph Conrad‚ this novel follows Marlow’s expedition into the unknown depths of the Congo in search of Kurtz and his adored wisdom. Conrad links Marlow’s physical journey to a psychological quest of discovery into evil and darkness inside each one of us. Through the impassable landscape‚ the language barrier between the colonists and the natives‚ and embodiment
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asserts the important discoveries in any field of inquiry are more likely made by the beginners‚ but not the experts. I strongly disagree with this view because it is an extreme one. Though I concede that some important discoveries may be attributed to the work of novices‚ but this situation is not a prevail phenomenon in all fields. Most of achievements people acquire are dependent on the research of experts. Admittedly‚ beginners could contribute to some important discoveries because their thought
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Outline the different theories and controversies surrounding the discovery of and settlement of New Zealand by East Polynesians. The discovery and settlement of new land in the world often involve myths. Similarly‚ there have been different theories and controversies surrounding the discovery of and settlement of New Zealand by East Polynesians. East Polynesians can be defined as a distinct ethnic group inhabiting Pacific islands such as the Society‚ Marquesas and New Zealand. This essay will
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“When I was at school we had a teacher whose fixed idea was to make us learn by heart the lives of famous women‚ in order to incite us to imitate them. The exhortation which accompanied these narrations was always the same. Would you not like to become famous?” “Oh no‚” I replied drily one day‚ “I shall never be that. I care too much for the children of the future to add yet another biography to the list.” (Her Life and Work‚ Chapter 1‚ p. 21). Despite not having an inclination of being famous‚ Dr
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Museum Volunteers Project Description: In this project‚ you will create a new table and share data with Excel in a database for the Burchard Museum of Science and Discovery. Additionally‚ you will establish relationships between tables‚ and then create queries within the database. Instructions: For the purpose of grading of the project you are required to perform the following tasks: Step Instructions Points Possible 1 Start Access. Open the downloaded Access database named
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more than a European cross country trip with my buddies. It was the thought of experiencing a completely different culture from my own‚ making new friends‚ and leaving the comfort of my parents protection. I never thought it would all lead to self-discovery. I left for the airport that afternoon with a building anticipation in my heart. My mother was looking more than a bit gloomy and dad was simply quiet the entire car ride‚ while my sister and I chattered away about what we would do when we got there
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