Current Medicinal Chemistry‚ 2011‚ 18‚ 733-766 733 New Lead Structures in Antifungal Drug Discovery Chunquan Sheng and Wannian Zhang* Department of Medicinal Chemistry‚ School of Pharmacy‚ Second Military Medical University‚ 325 Guohe Road‚ Shanghai 200433‚ People’s Republic of China Abstract: During the past two decades‚ the incidence of invasive fungal infections has been increasing dramatically. Clinical available antifungal agents have several drawbacks such as limited potency and
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Scientific discovery is neither innately good nor bad; however‚ it does require the responsible yielding of that knowledge and the proper relaying to the scientific community. In the letters‚ the reader is introduced to Victor Frankenstein‚ on the verge of death‚ who even then speaks warmly of his scientific ambitions that he has since left in the dust and is now lonely himself. Speaking to Walton who is on his own journey of scientific discovery‚ Victor recognizes the mistake Walton is apt to make
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I remember when It was the beginning of May and I knew my days with my friends were numbered I was going to a different‚ I wanted to spend as much time I could with them. Life at child discovery center also known as GRCDC was amazing I had been there for four years and I had so many friends and when you went to a new grade there was no way you could get separated from your friends cause all you would do is go to a different class room like there would be two classrooms for each grade it was so awesome
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to be one of those people who took a chance; for that is why I’ve become one of the most remembered people in all of American history. Hello‚ my name is Meriwether Lewis. Most people probably already know that I was a co-leader in the Corps of Discovery‚ but many do not know my entire life story. For that reason I’ll start where it all began. I was born on a warm summer day in August of 1774 in the small county of Albemarle. I was born and grew up
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Human tendency to categorize others extends to simple instinct. From the moment a baby is born‚ the first question already categorizes the baby: boy or girl. In Richard Rodriguez’s Brown: The Last Discovery of America‚ he addresses these ideals of categorizations‚ untangling arduous inner conflicts in the process. Due to his diversity‚ Rodriguez feels unwanted and omitted in his day-to-day life. With a lack of a category for himself‚ Rodriguez journeys to discover new parts of himself and embrace
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Holden Caulfield undertakes a journey of personal discovery. Every journey begins with a first step. What are Holden’s first steps? How does his character react to the world around him as he begins his ‘hero’s quest’? Holden Caulfield is an extremely unique character. Through his inability to conform to the rules of the adult world that he is sucked into‚ he frequently criticizes people and is extremely judgemental to those around him. He calls people who reject him “phonies”‚ as a way to psychologically
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Discovery of Sensation and Perception from TV drama From the word ‘psychology’‚ ‘psycho’ refers to ‘psyche’ which means ‘mind’‚ ‘soul’‚ ‘breath’ and ‘spirit’; and ‘logy’ refers to ‘study of’ or ‘research’ (Online Etymology Dictionary‚ 2001). And according to Andrew (2009)‚ psychology defined as ‘treats of the soul’. And I define psychology as knowledge which enables us to interpret a person’s mood and thought by observing his or her motion. For example‚ when a person tells lies‚ he or she may
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The first video‚ aptly named "Amazing Discoveries‚" discusses the complexities of memory formation in the human brain‚ and how it can be difficult for us to remember certain factors or situations regardless of how important they may be. It highlights that while certain types of memories‚ such as procedural‚ emotional‚ and spatial memories‚ are often strong and reliable‚ memories related to school-based learning may not be as well encoded. For example‚ a child may remember what video game they played
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It will be unfair if we do not acknowledge the services and work of Dr. Maria in discovering the child. She was a keen observer of children. She studied them scientifically. She conducted various studies and found that children loved to do small constructed work provided it suited the age and stage of development. She also found that children reveal inner need for order. Children are also capable of choosing their own activity suitable to their capacity. Following are the main findings she
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LI 532 Paper #3 February 27‚ 2008 East of Eden: The Discovery of Innocence on the Western Frontier What happens in the West? What kind of change takes place when an individual crosses over the boundary separating what has been settled from what has yet to be— the frontier. Over the last few weeks I have continued to probe the idea of the West as a place that has yet to be defined. Many times‚ authors and people are not even sure where it starts as it is an invisible border that exists only
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