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2a 2b Therapeutic Confirmatory 3a 3b Objective PK /PD /Other Enable go/no-go decisions to be based on relevant human models instead of relying on sometimes inconsistent animal data. Safety & tolerability-Maximum tolerated dose PK PD safe dose range PK Safety Efficacy PK Safety Efficacy Safety Special studies (Qol‚ DDI‚ FDI) Sub group Efficacy Safety Special studies (Qol‚ DDI‚ FDI‚ PE) Info for mkt Subjects Generally Healthy volunteer Generally Healthy
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purchased from other sources. Number of doses produced by any bull varied from few hundreds to seventy thousands with an average of 20‚566 ± 2438 doses during their average stay of 82.6 ± 6.7 months at the SPU. The five thousand doses expected to be stored under the progeny testing program could therefore take as long as four years (Y = 36.6 + 2.24 X; R2 = 66%). There was no association between BLUP EBV’s for lactation milk yield and the number of semen doses produced (r= -0.05). Computerized continuous
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systemic circulation. It reduce: amount of unmetabolized drug‚ bioavailability and drug effects. 4. Boavailability Bioavailability is a measure of the fraction (F) of administered dose of a drug that reaches the systemic circulation in the unchanged form. BA=A/D x 100% (A: Total amount of drug in SC; D: Administrated dose)) * Bioavailability indicates the rate and extent of absorption into the circulation following extravascular administration of drugs. 5. Half-life Time it takes for a drug concentrations
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equation can now be used to predict the relationship between agonist concentration and tissue response. If this equation holds‚ and agonist concentration is directly proportional to tissue response‚ and the law of mass action applies‚ then after using a dose response curve to plot log(y/100-y) against log [A] we would get a hill plot with a straight line and a slope of
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references‚ guidelines‚ and high-alert meds. One last recommendation is communication‚ share information‚ write clear‚ and avoid abbreviations. Require all unused drugs to be returned to the pharmacy and having the computerized checking system double check doses every time. 6. What are some risk factors that lead to medication errors? Medication errors can be a result of long work shifts‚ inexperience staff‚ medical services such as an interpreter‚ multiple medications for a single patient‚ environmental factors
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care Remember to avoid BVM use if it͛s not necessary Remember the basics and provide Oxygen Remember suction THAT WORKS particularly with portables. Lidocaine is thought to decrease ICP but no good studies to prove either way Peds: (up to 10yoa) dose 0.01mg/kg‚ if you give below 0.1mg/kg
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hospitals to makes sure that machine was calibrated properly‚ and to examine each treatment. As of today the machines are still being used around the world‚ with claims that “they are absolutely safe” (Fatal Dose‚
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Caffeine What do you call a cow who’s just given birth? De-calf-inated! How many of you have had a cup of coffee today? How about a soft drink? Chocolate? An Excedrin? All of the above products have one thing in common: They all contain caffeine. In this speech‚ we’ll look at caffeine’s origins and how it spread‚ some caffeinated products‚ and the effects that caffeine has on the body. On any given day‚ four out of five Americans have a already digested it‚ making it the World’s most popular
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being 131Iodine.12 This nuclear fallout contaminated 23% of the state of Belarus‚ some parts of Russia and Ukraine‚ as well as regions of Poland‚ the Czech Republic‚ Scandinavia and southern Germany. 36 hours after the meltdown‚ highly increased doses of atmospheric radioactivity were measured in Germany‚ Switzerland‚ the Czech Republic and even as far as Scandinavia. Due to rain and wind currents‚ 70% of radioactivity came down in Belarus‚ most of it in the regions of Gomel and Mogilev‚ 15% in
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