GENERAL APPROACHES FOR DOSE ADJUSTMENT IN RENAL DISEASE Renal insufficiency can markedly alter one or more of the pharmacokinetic parameters of a drug including oral bioavailability‚ volume of distribution‚ drug binding to plasma proteins‚ and most importantly the rates of metabolism and excretion‚ i.e.‚ drug clearance.. To minimize drug toxicity and maximize therapeutic benefits‚ it is often necessary to adjust drug dosage in proportion to the degree of renal insufficiency. A drug will most
Premium Pharmacology Nephrology Renal failure
An enabling aspect of our Phase 2 effort will be use of two improved models‚ including our novel 2-dose CP model in mice developed in Phase 1 that for the 1st time‚ reproduces the AKI and CKD pattern in humans treated with CP. Given the potential advantages a peptide agonist vs. RNLS protein‚ including reduced potential for cardiovascular side effects and immunogenicity; ease of manufacturing and stronger intellectual property‚ we will confirm and extend that a peptide agonist is equal or better
Premium DNA Gene Immune system
Dose Adjustments in Patients with Impaired Renal Function Prof. Hartmut Derendorf University of Florida Chronic Kidney Disease Major world-wide health concern In US number of patients requiring dialysis or transplant is projected to increase from 340‚000 in 1999 to 651‚000 in 2010 National Kidney Foundation-attempts to standardize definition‚ stages and laboratory tests to assess kidney function Am J Kidney Dis. (2000) 366 suppl 2:S1–S279 S-M Huang et al. Clinical Pharmacology & Therapeutics
Premium Nephrology Renal failure Renal physiology
researcher is suggesting that media violence is “the” cause of violent behavior? Is developmental perspective essential to an adequate understandingof how media violence affects youthful conduct and to the formulation of a coherent public health response to this problem? Do small statistical effectsnecessarily translate into small practical or public health effects? Before reviewing the research literature‚ however‚ we must emphasize
Premium Violence Media violence research Crime
What does it mean to be human What does it mean to be human? What is a human? What makes someone human? Although‚ some opinion may be as same or difference because of the answer have vary from person to person.I belief human must have three main characteristic to be a human. First‚ in physical human have large brains compared with body size and body weight which it has many nervous cells. Brains include Cerebrum‚ Thalamus‚ hypothalamus‚ Cerebellum‚ pons and Medulla. Humans are the only animals
Premium Brain Psychology Incandescent light bulb
Does Age Really Matter? Some people may think that age matters in relationship while others say that relationships work best when the male is older‚ but I do not agree with either ideology. I used to believe that age matters in a relationship but after personally going through an experience that counteracted those beliefs‚ I finally believed. When my cousin‚ Mojgun‚ met the love of their life no one‚ including myself‚ ever believed that the relationship would work‚ especially since she was
Premium Goal Marriage
In William Shakespeare’s play‚ Romeo and Juliet‚ both Romeo and Juliet are tragic heroes with tragic flaws. They both share the same tragic flaw‚ which is immaturity. This is illustrated when they "fall in love" before even getting to know each other. Also‚ their immaturity is shown when they fail to think their situation through before getting married without their parents’ consent. Romeo’s immaturity is what caused him to kill Tybalt; Juliet’s immaturity is what caused her father to push her wedding
Premium Romeo and Juliet Characters in Romeo and Juliet Marriage
difference between Lex‚‚ Leq‚t and Dose. (6 marks) LexT‚ - is the level of a worker’s total exposure to noise in dBA‚ averaged over the entire shift length or workday and adjusted to an equivalent 8 hour exposure based on a 3dB exchange rate. It always reflects the sound level for an 8 hour work day. This parameter also allows for a comparison
Premium Discounted cash flow Cash flow Cash
Does Globalisation lead to development? Discuss “Globalisation” is becoming a buzzword mentioned by increasing number of people. With the improvement of transportation and the emergence of internet‚ the distance of individuals is becoming closer; moreover‚ international trade seems to be freer and more frequent. Aninat (2001) defines globalisation as “the increasing interaction among and integration of diverse human societies in all important dimensions of their activities” including economic‚ environmental
Premium Poverty Economic development Economics
Dose the advertising help or harm us? Since the media has been coming in this age‚ advertising is growth very fast such as advertising about food‚ computer‚ beer etc. Because of population is increasing in differences way from year to year‚ advertisers try to persuade and support their products to buyers. Manu people are happy to know about advertising. For my idea‚ advertising really help and harm us. Advertising can help us many points. You can get new information about products from many
Premium Advertising Mass media