the Relative Rates of Electrophilic Aromatic Substitution Reaction Justiniano‚ Priscilla Raiza N. School of Chemical Engineering and Chemistry‚ Mapua Institute of Technology‚ Intramuros‚ Manila‚ Philippines Experiment No.1‚ Submitted on August 6‚ 2011 at N402. Abstract EXPERIMENT NUMBER ONE IS ALL ABOUT THE ELECTROPHILIC SUBSTITUTION OF AROMATIC COMPOUNDS. AROMATIC COMPOUNDS ARE THOSE ORGANIC COMPOUNDS WHICH HAVE BENZENE RING (CYCLOHEXA-1‚3‚5-TRIENE). AROMATIC COMPOUNDS ARE ALWAYS
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Electrophilic Aromatic Substitution: Bromination of Aromatic Compounds Introduction: The experiment focuses on finding out what kind of activating effects that four different substituents will have on an aromatic benzene ring. The substituents being tested are aniline‚ anisole‚ acetamide (acetanilide)‚ and phenol. All four of these groups are either para or ortho activating. Bromination is the reaction that will be carried out. The melting point ranges of the final products will be taken in order
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ABSTRACT: The electrophilic aromatic substitution reaction is the attack of a benzene ring on an electrophilic species resulting in the substitution of a proton with a functional group. The electrophilic aromatic substitution reaction nitration is used to nitrate methyl benzoate and acetanilide with a nitronium ion. Crystallization was used to purify the product. The melting point was used to determine its purity and the regiochemistry of the products. The methyl benzoate reaction product‚ methyl
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Electrophilic Aromatic Substitution Objective The objective of this experiment was to illustrate electrophilic aromatic substitution by synthesizing p-nitroanilide (as well as ortho) from acetanilide by nitration. The para form was separated from the ortho form based on solubility properties using recrystallization techniques. Synthetic equations: Physical Properties & Hazards of Reagents/Products: (all taken from Sigma-Aldrich website) Acetanilide MM = 135.16 g/mol Melting point =
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Muraleedharan Aromatic electrophilic substitution (Ar-SE) Reactions The special reactivity of aromatic systems towards electrophiles arises mainly from two factors: the presence of π electron density above and below the plane of the ring - making it nucleophilic‚ and the drive to regain the aromatic character by opting for substitution as opposed to a simple addition reaction. Preference towards addition reactions in the case of alkenes and substitution in the case of aromatic compounds becomes
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Experiment #1 – Aromatic Nitration The purpose of this lab is to convert toluene to nitrotoluene through the process of aromatic nitration. This is done by electrophilic aromatic substitution. The aromatic organic compound‚ toluene‚ is reacted under mild conditions with an electrophile‚ the nitronium ion‚ resulting in a product of nitrotoluene. Failure to use mild conditions may result in polynitration. Different reaction conditions were studied to understand the effect of nitrating agent
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the concept of electrophilic aromatic substitution‚ which is a type of benzene reaction. This reaction consists usually of benzene and an electrophile. The role of the nucleophile is played by the double bond on the benzene ring. IT will react will the electrophile and this reaction will form a carbon cation intermediate. With additional reactions with a base‚ the electrophile fundamentally replaces the hydrogen of the benzene. Benzene is classified as one of the countless aromatic molecules‚ and
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Experiment #1 Nucleophilic Aromatic Substitution of 2‚4-dinitrochlorobenze Name: Anouk Deck-Leger Student I.D: 9380868 Date performed: September 13th‚ 2010 Due Date: September 20th‚ 2010 Introduction: The company DNCB produces large amounts of 2‚4-dinitrochlorobenzene and they sell this product to treat against warts and severe and chronic hair loss. It can also be used as an alternative treatment for HIV. The supervisor notices an excess amount of m-aminobenzoic acid stored away which
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RELATIVE RATES OF ELECTROPHILIC AROMATIC SUBSTITUTION Juris Marie G. Garcia Institute of Chemistry‚ University of the Philippines‚ Diliman‚ Quezon City Date Performed: February 27‚ 2015 Date Submitted: March 13‚ 2015 Answers to Questions: 1.) Arrangement of Reactivity: (fastest to slowest) - Phenol‚ Nitrophenol‚ Acetanilide‚ Benzene‚ Chlorobenzene‚ Aniline - A reaction has occurred if there’s a change in color. The nature of the substituent‚ whether electron-donating to the ring or electron-withdrawing
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Objective: To perform an electrophilic aromatic substitution reaction‚ predict the effect on substituent orientation‚ and determine the identity of the product and mechanism for product. Procedure: Schoffstall‚ A.M.‚ Faddis‚ B.A.‚ and Durelinger‚ M.L. Microscale and Miniscale Organic Chemistry Laboratory Experiments‚ 2nd Ed.‚ McGraw-Hill‚ 2004‚ pages 215-218. Experiment 12.2 A Changes: Part A- No methanol recrystallization. Results and Observations
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