XTANDI (Enzalutamide) – Does it have potential to compete against ARN-509 in earlier setting? Zytiga (Abiraterone Acetate) – Ongoing Combination trials creates potential beyond Patent Expiry In recent past approval and launch of various newer treatment options like Xtandi (Enzalutamide‚ Astellas/Medivation)‚ Zytiga (Abiraterone acetate‚ JNJ)‚ Jevtana (Cabazitaxel‚ Sanofi)‚ & Xofigo (radium Ra 223‚ Boehringer Ingelheim) has evolved the treatment paradigm of treating late stage prostate cancer. In
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ACTIVITY 1: THE RESTING MEMBRANE POTENTIAL 1. Explain why increasing extracellular K+ reduces the net diffusion of K+ out the neuron through the K+ leak channels? When the diffusion is greater on one side‚ the other side will slow down. 2. Explain why increasing extracellular K+ causes the membrane potential to change to a less negative value. How well did the results compare with your predictions? There are two potassium’s for every sodium so the increase of potassium will make it more
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[pic] |THE MECHANISM FOR THE ACID CATALYSED HYDROLYSIS OF ESTERS | | | |This page looks in detail at the mechanism for the hydrolysis of esters in the presence of a dilute acid | |(such as hydrochloric acid or sulphuric acid) acting as the catalyst. It uses ethyl ethanoate as a typical| |ester.
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Synthesis of Aspirin and Oil of Wintergreen Janelle Alyssa P. Prudente De La Salle University-Dasmariñas Dasmariñas City‚ Cavite‚ Philippines ABSTRACT In this experiment‚ acetylsalicylic acid commonly known as aspirin and methyl salicylate‚ commonly known as oil of wintergreen‚ was synthesized from salicylic acid. This study will show that it is possible to show two very different organic compounds from the same common starting material. For the synthesis of aspirin‚ salicylic acid
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E r J. Biochem. 40‚177-185 (1973) u. Intracellular Titration of Cyclic AMP Bound to Receptor Proteins and Correlation with Cyclic-AMP Levels in the Surviving Rat Diaphragm Lien DO KHAC‚Simone HARBON Hubert J. CLAUSER and lnstitut de Biochimie‚ Universit6 de Paris-Sud‚ Orsay (Received April 9/July 17‚ 1973) Extracts prepared from rat diaphragms incubated with or without theophylline and/or epinephrine have been tested for their total cyclic AMP content and for their ability to bind exogenously
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polymers‚ DuPont has remained a leader the field. In addition to Elvax®‚ DuPont makes high impact polystyrene (HIPS)‚ which is also produced by other manufacturers. ELVAX® 150W: Manufactured by DuPont‚ Elvax® is a copolymer of ethylene and vinyl acetate (EVA). It is flexible‚ resilient‚ tough‚ and resistant to ozone or environmental stress cracking. Elvax® can be used alone or as an additive to improve other resins or elastomers. With no plasticizer to migrate and minimal odor‚ Elvax® has advantages
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Swimmers ear: Infection of the skin covering the outer ear canal that leads in to the ear drum‚ usually due to bacteria such as streptococcus‚ staphylococcus‚ or pseudomonas. Swimmer’s Ear Symptoms • The most common symptom of swimmer’s ear is pain. Pain gradually begins over a day or two. The pain almost always involves only one ear. The pain is especially intense when the ear is touched or pulled. • The ear canal may itch. • The outer ear may be red‚ and in severe cases the ear
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from a weak acid and a strong base hydrolyze to form a solution that is slightly basic. In this kind of hydrolysis‚ it is the anion from the weak acid that actually reacts with the water. For example‚ when sodium acetate‚ NaC2H3O2‚ hydrolyzes‚ water molecules react with the acetate ion: C2H3O2- + H2O ---------> HC2H3O2 + OH- The formation of the OH- ion from this reaction makes the solution basic. Salts formed from a week
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use of elaborate apparatus (17). “They were predestined to emigrate to the tropics‚ to be miner and acetate silk spinner and steel workers” (13). Subordinate Clauses: “He had a long chin and big rather prominent teeth” (6). At the same time‚ we see to it that all country sports shall entail the use of elaborate apparatus (17). “They were predestined to emigrate to the tropics‚ to be miner and acetate silk spinner and steel workers” (13). Conditional Clauses: “If any of the eggs remained unfertilized
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--- Experiment 1 : Thin-layer Chromatogragaphy : Analysis of Drug Components CHEM221 Date experiment performed : January 20‚ 2014Date Submitted : January 27‚ 2014 Introduction This laboratory has its first objective to familiarize with the thin layer chromatography (TLC) technique. Second‚ each student has to identify the unknown components by comparing it to one of the tree dissolved liquid analgesics: Acetaminophen‚ Aspirin and Caffeine. Finally‚ calculating the Rf value by measuring
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