EXERCISE 11 SYNTHESIS OF ASPIRIN MARAVILLA‚ Ana Mikaela B Group 4 CHEM 40.1 1L Date performed: September 30‚ 2013 Date submitted: October 7‚ 2013 VI. RESULTS AND DISCUSSION Aspirin is prepared by the esterification of salicylic acid with acetic anhydride under acidic conditions. The phenol group in salicylic acid is replaced by a carboxyl group through electrophilic substitution. The mechanism for the reaction can be summarized
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preparation of aspirin and oil of wintergreen | Introduction Organic compounds are those which contain carbon as well as a select other elements. An organic acid however‚ is an organic compound which contains acidic properties. An ester is an example of being a derivative of these organic acids. Esters can be prepared by the reaction of carboxylic acids and alcohols‚ with an inorganic acid used as a catalyst which is dubbed esterification. With o-hydrobenzoic acid‚ or salicylic
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Synthesis of Aspirin and Oil of Wintergreen INTRODUCTION: Synthesis and use of organic compounds is an extremely important area of modern chemistry. Approximately half of all chemists work with organic chemicals. In everyday life‚ many if not most of the chemicals you come in contact with are organic chemicals. Examples include drugs‚ synthetic fabrics‚ paints‚ plastics‚ etc. Synthesis of Aspirin and Methyl Salicylate. The two compounds we will be preparing‚ aspirin (acetylsalicylic acid) and oil
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Greaves Chem3301-112 June 19‚ 2013 Synthesis of Aspirin from Methyl Salicylate Introduction The synthesis of Aspirin (Acetyl Salicyclic Acid) began with methyl salicylate and sodium hydroxide as the reagent. The polar oxygen accepts the electrons from now positively charged hydrogen. The positively charged sodium disassociates leaving the hydroxide ion with a negative Scheme 1 shows the mechanisms that were demonstrated during the synthesis of Aspirin. charge that attracts to the positively charged
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Preparation of an Ester Acetylsalicylic Acid (Aspirin) OBJECTIVE: To become familiar with the techniques and principle of esterification. DISCUSSION: Aspirin is a drug widely used as an antipyretic agent (to reduce fever)‚ as an analgesic agent (to reduce pain)‚ and/or as an anti-inflammatory agent (to reduce redness‚ heat or swelling in tissues). Chemically‚ aspirin is an ester. Esters are the products of reaction of acids with alcohols‚ as shown in the following equation using
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MEMORANDUM From: To: Subject: Calcium Chloride Best Purchase for Deicing Enclosures: (1) Data Record (2) Data Treatment (3) Environment Impact Research After hours of vigorous examination‚ we have come to the conclusion that calcium chloride (CaCl2) would be the best deicer to use on a naval base over sodium chloride (NaCl) and ethylene glycol (C2H6O2). In order to melt ice‚ deicers lower the freezing point so that the ice melts at lower temperatures. CaCl2 has
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man neutralized salicylic acid by buffering it with sodium (sodium salicylate) and acetyl chloride‚ creating acetylsalicylic acid. In 1897‚ Felix Hoftmann invented acetyle salicylic acid (ASA) for Bayer – a formulation of salicylic acid which did not have the unpleasant side effects of its predecessor. The person in charge of Bayer’s testing laboratories shelved this new drug for two reasons. Initial test on ASA were not
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OF ASPIRIN Aspirin in general is a safe drug but the ability to prevent blood clots is connected to some side effects. Aspirin can cause firstly stomach irritation. That’s means aspirin can irritate your stomach which has as a result pain‚ nausea‚ vomiting or hearburn. Sometimes can have other symptoms like bleeding‚ holes in stomach or intestines. In order to minimize these problems it should be better to have a full stomach. Also another problem that comes from aspirin can
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Formal Report no. 1 Synthesis of Aspirin Chemical Principles Aspirin is most widely sold over-the-counter drug. It has the ability to reduce fever (an antipyretic)‚ to reduce pain (an analgesic)‚ and to reduce swelling‚ soreness‚ and redness (an anti-inflammatory agent). Much of this is believed to be due to decreased production of prostaglandins and thromboxanes. Aspirin’s ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX)
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Reshmi Nair Title: Determination of Aspirin through back titration. Aim: To determine the concentration of Aspirin in a tablet using NaOH and Hcl. Research Question: What is the concentration of Aspirin in a normal tablet? Background: Aspirin is the general name for acetylsalicylic acid (ASA); it is also the trademark of the drug produced by Bayer in Germany. In eighty countries‚ aspirin is a registered trademark‚ but in other places the term aspirin refers to ASA by itself or as an ingredient
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