sebacoyl chloride with the loss of HCl via nucleophilic substitution. Cellulose triacetate was generated by mixing cotton balls and acetic anhydride with acidic condition under heating. Materials: Styrene‚ 1 M NaOH solution‚ CaCl2(s)‚ xylene‚ t-butyl peroxybenzoate‚ methanol‚ 5% aqueous solution of 1‚ 6-hexanediamine‚ NaOH(s)‚ 5% sebacoyl chloride in hexane‚ glacial acetic acid‚ concentrated H2SO4‚ cotton balls‚ acetic anhydride‚ CH2Cl2 Procedure: For the synthesis of polystyrene‚ 10 ml styrene
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Reminder: These notes are meant to supplement‚ not replace‚ the laboratory manual. A Diels-Alder Reaction History and Application: The 1950 Nobel prize in chemistry was awarded to Otto Paul Hermann Diels and Kurt Alder for their breakthrough work on the discovery and development of [4 + 2] cycloaddition reactions i. This set of reactions are enormously useful in the synthesis of six membered rings in a single stepii. These are used in many pharmaceutical applications. Tamiflu® is a drug which
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as well as spotting the standard spinach extract. A beaker was used with the developing solvent‚ filter paper‚ and TLC plate inside and a watch glass over top of the beaker to perform the thin layer chromatography. After the solvent front (30% ethyl acetate in hexane) reached about an inch from the top‚ the TLC plate was removed from the beaker and the developing spots were marked. After implementing the column and thin layer chromatography‚ the Rf value for component one was .95‚ for component two
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The column fractions were collected in 25 ml test tubes. In that‚ fraction number 271-275th showed identical clear spot which were loaded on the activated silica gel TLC plates (20 cm × 20 cm). The plates were developed using methanol: ethyl acetate (60:40) solvent system. The single spot was located by exposing the plate to iodine fumes. Thus‚ it may indicate the presence of single
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in nonracemic form directly from an achiral precursor. First‚ racemic ibuprofen was converted to aN achiral ketene via the acid chloride by adding thionyl chloride followed by triethylamine. Then‚ ketene was reacted with a chiral and nonracemic (S)-ethyl lactate produces a mixture of diasteromeric esters of ibuprofen derivatives where (S) configuration is predominantly. Finally‚ hydrolysis of the ester then provides (S)-ibuprofen in a relatively high yield. all reaction were monitored by TLC at room
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Nitration of Methyl Benzoate Purpose: The purpose of this experiment was to synthesize methyl m-Nitrobenzoate from methyl benzoate‚ concentrated HNO3‚ and concentrated H2 SO4 by an electrophilic substitution reaction. The H2 SO4 and the HNO3 were initially combined to form nitronium ion which was then used as an electrophile in the reaction. Crystals that were collected after the formation of the methyl m-Nitrobenzoate were collected by vacuum filtration and the product was isolated and purified
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steps involved protecting the ketone of ethyl acetoacetate with a ketal group‚ followed by preparation and reaction with Grignard‚ then purification by extraction and recrystallization. The yield was 78.5%‚ but there are impurities present suggested by 1H-NMR‚ IR‚ and TLC. However‚ the results do indicate the desired hydroxyketone was formed. Introduction: The purpose of this multi-step lab was to synthesize 4-hydroxy-4‚4-diphenylbutan-2-one from ethyl acetoacetate. The Grignard reaction is widely
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S OUTHEAST ASIAN J T ROP MED P UBLIC H EALTH ANTI-HEAD LICE EFFECT OF ANNONA SQUAMOSA SEEDS Junya Intaranongpai 1‚ Warinthorn Chavasiri 2 and Wandee Gritsanapan 1 1 Department of Pharmacognosy‚ Faculty of Pharmacy‚ Mahidol University‚ Bangkok; Department of Chemistry‚ Faculty of Science‚ Chulalongkorn University‚ Bangkok‚ Thailand 2 Abstract. The present study focused on the separation and identification of the active compounds against head lice from the hexane extract of Annona squamosa
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recrystallization. This experiment includes the determination of a good solvent for recrystallization for compounds such as: acetanilide‚ acetamide‚ aspirin‚ benzoic acid‚ naphthalene‚ and sucrose‚ for solvents such as: water‚ ethanol‚ benzene‚ and ethyl acetate. Also pure acetanilide is achieved. here are five major steps in the recrystallization process: dissolving the solute in the solvent‚ performing a gravity filtration‚ if necessary‚ obtaining crystals of the solute‚ collecting the solute crystals
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inside the shell. Subsequently‚ the thick white part is placed in a container together with 750mL of water‚ 100mL of ethyl alcohol and 5 tablespoons of potassium sorbate. The usage of potassium sorbate is significant because it serves as a preservative for the durian fruit. After 18-24 hours‚ the liquid was then distilled so that the extract can be acquired. When the distillation process was complete‚ the extract was transferred into recycled Yakult containers then distributed to 30 respondents for
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