Drug Metabolism Prof. Patrick Davis Basic Medicinal Chemical Principles PHR 143M Fall-08 Importance of Drug Metabolism • The basic premise: Lipophilic Drugs --> Hydrophilic Metabolites (Not Excreted) (Excreted) • Water soluble => increased renal excretion -anddecreased tubular re-absorption of lipophilics. Importance of Drug Metabolism CH 3 CH 2OH CHO COOH OH O C 2H 5 Δ1-THC PC=6000 - O C O O HO OH COO OH OH Excreted Form O C 2H 5
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2. Compare the development of lymphocytes with other formed elements. B lymphocytes develop in red bone marrow‚ T lymphocytes develop in red bone marrow and mature in the thymus; the other formed elements develop in red bone marrow 3. What is erythropoiesis? Which factors speed up and slow down erythropoiesis? Erythropoiesis is the process by which red blood cells (erythrocytes) are produced. If you lose a lot of blood‚ erythropoiesis will speed up; anemia can cause erythropoiesis to slow down
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“ Ageing is a continuous‚ complex‚ and dynamic process that begins with birth and ends with death. And unless we die in our early years‚ each of us will grow old and experience the effects of the ageing process”. (Pirkl‚ 2009). The ageing process and why changes have taken place in the last fifty years. This report discusses the ageing process and why changes have taken place in the last fifty years. The ageing process is a change in an organism overtime and can be referred to as a multidimensional
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El Valle‚ when she went to the main street there were golden frogs that basically represented their local street‚ and people even made souvenirs of them‚ but then she noticed that the population of the frogs had decreased. In the town of el Valle there were always golden frogs‚ she liked those frogs so much that she went on and established a research site so later she could study them. Lips decided she wanted to study the local frogs
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Human Physiology Lab Special Senses Cutaneous Senses and Vision September 24/26‚ 2012 Our bodies are capable of sensing a wide spectrum of stimuli. We are consciously aware of some of the information our bodies perceive‚ but much of the information that is sensed is beyond our consciousness. Receptors responsible for perception of stimuli are found in many places: skin‚ eyes‚ ears‚ mouth‚ blood vessels‚ lungs‚ brain—frankly‚ every cell in the body has sensory receptors. These receptors are
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LABORATORY REPORT RENAL PHYSIOLOGY INTRODUCTION: The kidneys‚ which maintain the purity and constancy of our internal fluids‚ are perfect examples of homeostatic organs. They regulate the chemical content the pH and osmotic pressure of the blood. Kidneys filter gallons of fluid from the bloodstream. They then process this filtrate‚ allowing wastes and excess ions to leave the body in urine while returning needed substances to the blood in just the right proportions. Factors that affect urine
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tissue which provides the skins elasticity and strength it also contains sensory nerve endings‚ blood and lymph vessels‚ sebaceous and sweat glands. Under this layer is the subcutaneous fat layer; this separates the skin from the underlying bone and muscle with rich blood supply it also serves as an insulator and energy store. Pressure ulcers develop when a large amount of pressure is applied to an area of skin over a short period of time. Or‚ they can occur when less force is applied but over a period
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ANATOMY AND PHYSIOLOGY Chronic Kidney Disease Cardiovascular System The cardiovascular system is sometimes called the circulatory system. It consists of the heart‚ which is a muscular pumping device‚ and a closed system of vessels called arteries‚ veins‚ and capillaries. As the name implies‚ blood contained in the circulatory system is pumped by the heart around a closed circuit of vessels as it passes again and again through the various "circulations" of the body. The Heart * The heart
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Clint Casey Planarians I. Diet: Planarians are carnivorous and eat other smaller animals. They also eat detritus‚ diatoms‚ dead animals‚ and decaying organic matter. (1) II. Predators: Larger carnivores eat planarians. Some fish such as the Crossocheilus siamensis (Siamese Algae Eater) have been studied to remove planarians from fish tanks. (3) III. Range: Most planarians live in fresh-water bodies. They also live in all oceans‚ and in moist terrestrial habitats. (5) IV. Microhabitat:
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Fluid‚ Electrolyte‚ and pH Balance 1. The maintenance of normal volume and composition of extracellular and intracellular fluids is vital to life. List and briefly describe the kinds of homeostasis involved. In males and females‚ intracellular fluid has a greater proportion of total body water than does extracellular fluid. Give-and-take between the ICF and the ECF happens across plasma membranes by osmosis‚ diffusion‚ and carrier-mediated transport. The kinds of homeostasis involved are fluid
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