Tay Sachs Disease Tay Sachs disease is caused by the homozygous recessive gene on chromosome 15 that codes for the lack of production of hexosaminidase-A (Hex-A) [1]. Since there is no HexA‚ a fatty substance is allowed build up abnormally in nerve cells‚ which damages the cells and the brain [1]. Males and females are equally likely to carry this recessive gene but the heterozygous gene carriers are not affected‚ because they still have the dominant gene [2]. If both parents have the heterozygous
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Tay-Sachs Disease History: The disease is named for Warren Tay (1843-1927)‚ a British ophthalmologist who in 1881 described a patient with a cherry-red spot on the retina of the eye. It is also named for Bernard Sachs (1858-1944)‚ a New York neurologist whose work several years later provided the first description of the cellular changes in Tay-Sachs disease. Sachs also recognized the familial nature of the disorder‚ and‚ by observing numerous cases‚ he noted that most babies with Tay-Sachs
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Emma Goldman perseverance towards equal rights‚ views on women‚ and reorganizing politics especially for women earned her‚ her place in history. Emma was born in Lithuania‚ but she moved to a czarist Russian ghetto called Kovno until 1886.(“Was My Life Worth Living?”‚ 2000) Her father discouraged her from having an education‚ and he told her that her only meaning in life was marrying and having a family.(“Emma Goldman: Overview‚ 2003) She moved to New York to live with her sister Lena at the age
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Tay-Sachs is a devastating disease affecting lysosomal storage. According to McCance & Huether (2014)‚ it is due to a deficiency in the lysosomal enzyme hexosaminidates A (HexA) that’s function is to degrade GM2 gangliosides (fatty acids) in nerve cells. Those diagnosed with Tay-Sachs do not have the ability to degrade this fatty acid and as a result‚ it builds up in the body causing nerve cell toxicity. It is genetically inherited through an autosomal recessive pattern meaning that both parents
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Many people in society today are having casual sex outside of the marriage more and more. Has sex lost its true purpose and morality? If so‚ is this correct and morally acceptable? Alan Goldman and Roger Scruton see sex and the morality of sex very different. Goldman believes sex is just that‚ sex between two people for pleasure while Scruton believe sex should always have love and emotion with a spouse or long term relationship. What is the true morality of sex and who is correct? Sex should
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PresidentsY/A | Political Philosophy | Achievements | Strengths | Weaknesses | Evaluation | Threats | Laws | GENERAL EMILIO FAMY AGUINALDOTerm: (1898- 1901) | | Aguinaldo is best remembered for the proclamation of Philippine Independence on June 12‚ 1898‚ in Kawit‚ Cavite. Aguinaldo formally established the first Philippine republic. He also designated diplomats who were assigned in the major world capitals to seek recognition of Philippine independence | | | | | | MANUEL LUIS QUEZONTerm:
Free Philippines Senate of the Philippines
Directional Policy Matrix 1. Introduction Many large companies comprise several distinct divisions or strategic business units (SBUs). So one of the challenges facing the parent company of a multi-divisional company is to allocate resources to each division. So in order to make wise decisions on resource allocation‚ is there a tool that can assist senior executives determine the direction for each division or SBU? Actually there are two tools‚ the BCG matrix and the Directional Policy Matrix (DPM). We have
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Tay-Sachs is a rare genetic disorder that slowly destroys nerve cells in the brain and spinal cord and this disease effects millions of people (Tay-Sachs GHR). Tay-Sachs can’t be spread as it’s a genetic disorder. It is caused by a genetic mutation in the HEXA genes (Tay-Sachs GHR). People who have Tay-Sachs have problems with the enzyme called beta hexosamidase A and this enzyme is supposed to clean up the buildup of the molecule called GM2 ganglioside within cells but if it doesn’t it leads to
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What is Tay-Sachs Disease? Tay-Sachs disease is a fatal genetic lipid storage disorder in which harmful quantities of a fatty substance called ganglioside GM2 build up in tissues and nerve cells in the brain. The condition is caused by insufficient activity of an enzyme called beta-hexosaminidase A that catalyzes the biodegradation of acidic fatty materials known as gangliosides. Gangliosides are made and biodegraded rapidly in early life as the brain develops. Infants with Tay-Sachs disease appear
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1) Tay Sachs disease is one of many lysosomal storage diseases‚ this is caused by the lysosomes inability to produce certain enzymes needed to breakdown macromolecules. In Tay Sachs‚ the lysosome is unable to produce the enzyme beta-hexosaminidase A‚ which breaks down gangliosides within brain cells. Tay Sachs predominantly affects infants‚ and unfortunately there is no cure‚ symptoms include seizures‚ deafness‚ progressive blindness‚ and muscle stiffness. Gaucher disease is caused by the inability
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