Postulated that acyclovir is metabolized by the alcohol dehydrogenase (ADH) enzyme to acyclovir aldehyde‚ which is metabolized by the aldehyde dehydrognase 2 (ALDH2) enzyme to 9-carboxymethoxymethylguanine (CMMG). Hypothesized that acyclovir aldehyde plays a role in acyclovir-induced nephrotoxicity. Human renal proximal tubular (HK-2) cells were used as in vitro model. The results indicates that acyclovir aldehyde is produced in HK-2 cells and that inhibition of its production by 4-methylpyrazole offers
Premium Hypertension Blood Obesity
Chapter 1 MULTIPLE CHOICE QUESTIONS Topic: Atomic Orbitals 1. A) B) C) D) E) In quantum mechanics a node (nodal surface or plane) is: a place where Ψ is negative. a place where Ψ is positive. a place where Ψ = 0. a place where Ψ2 is large. a place where Ψ2 is negative. Ans: C Topic: Atomic Orbitals‚ Molecular Orbitals 2. When the 1s orbitals of two hydrogen atoms combine to form a hydrogen molecule‚ how many molecular orbitals are formed? A) 1 B) 2 C) 3 D) 4 E) 5 Ans:
Premium Molecule Oxygen Covalent bond
do so because there is an anomeric carbon available in the cyclic form of the molecule which allows it to open into a straight-chain form containing an aldehyde group. The aldehyde in the straight-chain reacts with the copper ions in the reagent to produce the color change. Positive Results. Glucose‚ galactose and honey all contain aldehyde
Premium Glucose Disaccharide Carbohydrate
carboxylic acids in two stages‚ it forms an aldehyde and then to the acid. In this experiment‚ we are used to prepare benzoic acid from benzene. Potassium permanganate is used this operation as an oxidizing reagent‚ it is used to oxidize the benzoic acid as well as acting as a catalyst for the reaction. Potassium permanganate (KMnO4) is a very strong oxidant which is able to react with many functional groups‚ such as secondary alcohols‚ 1‚2-diols‚ aldehydes‚ alkenes‚ oximes‚ sulfides and thiols. It
Premium Chemistry Chemical reaction Oxygen
an alcohol can produce aldehydes‚ ketones‚ or carboxylic acids. One of the methods of oxidation is an aldol reaction through carbon-carbon bonds. The oxidation oxidizes primary alcohols to aldehydes and secondary alcohols oxidizes ketones. Tertiary alcohols are converted to the common oxidizing agents. Scheme 5.1: Aldehydes can be oxidized easily to carboxylic acids in aqueous medias and could cause over-oxidization because there is an extra hydrogen adjacent to the aldehyde. Though over-oxidization
Premium Alcohol
chemical actions. The carbohydrate‚ glucose‚ is a key component in generating adenosine triphosphate‚ also known as ATP. In order to analyze unknown glucose levels‚ a DNS assay was performed. By using 2-hydroxy-3‚5-dinitrobenzoic acid to oxidize the aldehyde group on the carbohydrate‚ the reducing end of glucose increases in absorbance of 540 nm. Using a UV spectrophotometer‚ the concentration was calculated by using a regression line of the standard curve. The experimental data concluded a 1068.912
Premium Fructose Sucrose Glucose
Carboxylic acids are compounds which contain a carboxyl group‚ -COOH group‚ where the -COOH group is attached either to a hydrogen atom or to an alkyl group. One of the example of carboxylic acid is benzoic acid( benzene carboxylic acid) which has a benzene connected to the carboxyl carboxyl group‚ -COOH group. It has a formula of C6H5COOH. The carbon atom of a carboxyl group has a high oxidation state. Therefore‚ that many of the chemical reactions used for their preparation are oxidations. In
Premium Oxygen Alcohol Hydrogen
UNIVERSITY OF THE GAMBIA LECTURE NOTES COURSE: PRINCIPLES OF CHEMISTRY II (ORGANIC CHEMISTRY) CODE: CHM 161 2ND SEMESTER SESSION: 2012/2013 LECTURER: ANTHONY F. ADJIVON UNIT 1 INTRODUCTION Organic chemistry started as the chemistry of life‚ when that was thought to be different from the chemistry in the laboratory. Then it became the chemistry of carbon compounds‚ especially those found in coal. Now it is both. It is the chemistry of the compounds of carbon along with other elements
Premium Carbon Atom Petroleum
found when 6 drops of 2‚4-dinitrophenylhydrazine were added to both 5 drops of benzaldehyde and 5 drops of acetophenone. Based on these data‚ it is possible to find alcohol by oxidation and aldehyde by observing precipitation Introduction This experiments is to find if one substance has alcohols‚ aldehydes or ketones. If one reactant is alcohol‚ the color of the reactant will be turned into green when 6 drops of potassium dichromate and 1 drop of concentrated sulfuric acid were added. Also
Premium Alcohol Ethanol Oxygen
CLASSIFICATION TESTS A. Acids There are relatively few suitable tests for carboxylic acids. Classification is based mostly upon solubility tests. If the compound is water soluble‚ test the aqueous solution of your compound with pH paper (also check the pH of the original water). If the compound is water-insoluble and it dissolves in 5% (1.5M) sodium hydroxide and 5% NaHCO3 solutions as performed in your solubility tests‚ it can be classified as a carboxylic acid. Establish an equivalence value
Premium Alcohol Amine Acid