Megan Wierzbowski Organic II Laboratory Wed. 11-1:50 Title: Grignard Reaction with a Ketone: Triphenylmethanol Part 1 Objective: The goal of this experiment is to learn to make Grignard reagents. The reactions of the Grignard reagents with ketones form tertiary alcohols. These reagents are highly air- and moisture-sensitive materials. We will observe the formation of the Grignard reagents‚ which magnesium metal is transformed into organometallic salts. Experimental Procedure:
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In this experiment‚ the production of a Grignard reagent (phenylmagnesium bromide) was performed from a bromobenzene reactant combined with magnesium and ether. Phenylmagnesium bromide was then transformed into a tertiary alcohol called triphenylmethanol‚ through addition of another compound called benzophenone‚ as well as additional ether. The end product of triphenylmethanol was analyzed via NMR and IR. Figure 1: Preparation of the Grignard agent by combining bromobenzene with magnesium and ether
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were divided into two categories. First the formation of phenylmagnesium bromide‚ and second the reaction of the phenylmagnesium bromide with the carbonyl compound. However‚ before any of this could be done‚ the refluxing apparatus for the Grignard reaction was to be flame dried until no moisture remained inside because any water would cause the reagent to decompose and an alkane to form. The reaction would subsequently fail. Drierite was placed inside a plastic drying tube as a drying agent‚ absorbing
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The Grignard Synthesis of 3-methyl-3-heptanol In this experiment‚ an example of an organometallic compound which has a carbon magnesium bond will be utilized to form a tertiary alcohol. Grignard reagents have been extremely useful in the synthesis of a large number of classes of organic functional groups. Although Grignard reagents are unstable and decompose in air and moisture‚ they can be prepared and used immediately with moderate difficulty in the undergraduate organic chemistry laboratory
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The absurdity of the methanol economy I had not actually heard of it‚ but a colleague mentioned it in the course of conversation: George Olah‚ the Hungarian-born U.S. chemist whose research is focused on hydrocarbons‚ strongly advocates the introduction of methanol as a chemical energy carrier. The basic idea is that‚ to be sure‚ we need to find a replacement for the short chain alkanes that constitute the major part of gasoline‚ aviation spirit‚ etc.‚ and which are used as the source of motive
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Methanol(CH₃OH) is a simple compound which is also known as methyl alcohol or wood alcohol.Methanol is colourless‚flammable and most importantly very toxic.They are naturally produced from volcanic gases‚vegetation and microbes.They can also be produced in the industry by synthesizing gas.The largest and the most important use of methanol is as a feedstock in the plastic industry.They are used to make methanal and hence variety of plastics‚based on reactions with phenol‚carbamide(urea) and melamine
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| Reactions of Grignard Reagents with Carbonyls | | | Tuesday 1:30 | 2/28/2012 | | Introduction This experiment explores the reactivity pattern for the addition of Grignard reagents to three different carbonyl groups: a ketone‚ an ester‚ and a carbonate. Grignard reagents are organometallic compounds that have a carbon-metal bond‚ such as carbon-magnesium. Grignard reagents are formed from the reaction of an alkyl‚ cycloalkyl‚ or aryl halide and magnesium metal in dry ether
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Methanol- Yes or No? Do you agree on building the world’s largest methanol plant in Tacoma‚ WA? Many people disagree‚ because the negative impacts far outweigh the positive ones. One negative impact is the plant would take up too much resource. In addition to that‚ the methanol plant will also change the environment. Here is how the two negative points can affect the world today. The first negative impact is the methanol plant will take a lot of resources. One detail to support the claim in “Redline
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Bethesda‚ MD. 1993. 2) U.S. Environmenal Protection Agency. Integrated Risk Information System (IRIS) on Methanol. National Center for Environmental Assessment‚ Office of Research and Development‚ Washington‚ DC. 1999. 3) Methanol Institute. (2011‚ July). Methanol health effects. Methanol Facts. Retrieved February 1‚ 2013‚ from http://www.methanol.org/Health-And-Safety/Safe-Handling/Methanol-Health-Effects.aspx 4) U. (1994‚ August). Chemicals in the Environment. EPA. Retrieved January/February
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Experiment 13: Synthesis of 1- Bromobutane An SN2 Reaction Theory: One of the methods of preparing alkyl halides is via the nucleophilic substitution reactions of alcohols. Alcohols are inexpensive materials and easy to maintain. However‚ they are a poor leaving group the OH group is a problem in nucleophilic substitution‚ this problem is fixed by converting the alcohol into H2O. Objective: The objective of this lab is to observe the synthesis of 1-bromobutane in an SN2 reaction‚ to see how a
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