October 9‚ 2013 Partner(s): Acetylsalicylic Acid Synthesis Theory. This experiment was carried out to see how the hydroxyl group on the benzene ring in salicylic acid reacts with acetic anhydride to form an ester‚ and to make aspirin. Synthesis of Acetylsalicylic Acid occurs by protonation of carbonyl (C=O) group‚ and a nucleophilic attack of OH on the acetic anhydride. The ferric chloride test and melting point were used to test the purity of the results. A hypothesized recovery rater of above
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Experiment # 3 Acetylsalicylic Acid Introduction: The purpose of this experiment is to create and isolate pure acetylsalicylic acid from the substances salicylic acid and acetic anhydride. Then one will find the melting point to determine purity. Procedure: Make a hot bath. Weigh some salicylic acid and place in conical vial. Add .480mL of acetic anhydride and a drop of concentrated phosphoric acid. Drop in a magnetic spin vane and attach air condenser to vial. Partially submerge it in
Free Aspirin Carboxylic acid Acetic anhydride
Synthesis of Aspirin Ling Tecson Gamido‚ Mitchiko Mariel M. Mizukami Abstract Acetylsalicylic acid‚ or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. It is synthesized from salicylic acid and ethanoic anhydride‚ both of small quantities. Phosphoric acid was used as a catalyst in the synthesis to speed up the process. Esterification is involved and the final product is aspirin with the presence of acetic acid as the byproduct. In order
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Lab #5: Grignard Reaction – Synthesis of Triphenylmethanol John Kang Chem 152L Performed: 7/20/04 Date submitted: ________________ Lab Partners: Sang Lee‚ Vicky Lai TA: John Stanko Abstract: This experiment explored the synthesis of triphenylmethanol through the use of Grignard reagents. The percent yield of the product was 10% on a relatively humid day. The melting point was calculate to be 127.2oC with a literature value of 162oC. An IR spectrum of the product was taken and used
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EXERCISE 11 Synthesis of Aspirin (Acetylsalicylic Acid from Salicylic Acid) RAQUID‚ Rency J Group 5 18L I. Introduction Due to the demand of certain reagents in the laboratory in order to perform and conduct further experiments or produce essential compounds‚ chemists continuously develop organic synthesis. This process aims to prepare and synthesize desired organic compounds from commercially or readily available ones by providing the simplest route in synthesizing the compound
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Experiment C. Aim: To protect one of two carbonyl groups (C1) in order to allow the other to react twice with a Grignard followed by removal of the protecting group by acid hydrolysis to give final product (C2). Method: Ethyl acetoacetate (30.03g)‚ ethylene glycol (15.01g) and toluene-p-sulphonic acid (0.13g) were added to a 250 cm3 round bottomed flask‚ containing a stirrer bar and toluene (100 cm3)‚ fitted with a condenser and dean-stark head. Solution was heated strongly under reflux using
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In this experiment‚ the production of a Grignard reagent (phenylmagnesium bromide) was performed from a bromobenzene reactant combined with magnesium and ether. Phenylmagnesium bromide was then transformed into a tertiary alcohol called triphenylmethanol‚ through addition of another compound called benzophenone‚ as well as additional ether. The end product of triphenylmethanol was analyzed via NMR and IR. Figure 1: Preparation of the Grignard agent by combining bromobenzene with magnesium and ether
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Name Lab Section GTA Station 1. Grignard Reaction Post-lab report Fill out the appropriate sections below. Show all work. Your calculated answers need to match the answers in the table. Also‚ attach the benzophenone and product spectra. Indicate appropriate stretches including differences in both spectra. Results | | Amounts and units | |Initial
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| Reactions of Grignard Reagents with Carbonyls | | | Tuesday 1:30 | 2/28/2012 | | Introduction This experiment explores the reactivity pattern for the addition of Grignard reagents to three different carbonyl groups: a ketone‚ an ester‚ and a carbonate. Grignard reagents are organometallic compounds that have a carbon-metal bond‚ such as carbon-magnesium. Grignard reagents are formed from the reaction of an alkyl‚ cycloalkyl‚ or aryl halide and magnesium metal in dry ether
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Experiment 11 Title: Spectrophotometric analysis of caffeine and benzoic acid in soft drink. Name: Tan Herh Lim Name of partner: Sia Ting Wai‚ Chong Zheng Yee Date: Lecturer: Dr. Neo Kian Eang Practical class: P1 Objective: To obtain the absorbance of the caffeine and benzoic acid in soft drinks. Introduction Soft drinks that commonly found in our daily life contain caffeine and sodium benzoate. The caffeine act as a stimulant and the sodium benzoate acts as a preservative
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