HEMATOLOGY ORGAN SYSTEMS SMALL GROUP ANSWER KEY Case 1 1. Iron deficiency vs thalassemia vs anemia of chronic disease. 2. Serum iron‚ TIBC‚ ferritin. 3. Blood loss‚ likely GI. A GI evaluation is indicated. 4. Slow response (weeks) to oral iron. 5. Incorrect diagnosis‚ non-compliance‚ continued blood loss. Case 2 1. Anemia of chronic disease vs iron deficiency. 2. Serum iron‚ TIBC‚ ferritin. 3. Consistent with ACD‚ but also iron deficiency with inflammation. 4. Bone marrow iron stain
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The mutation prohibits oxygen from being transported to tissues. Typically‚ hemoglobin is made up of two alpha-globins and two beta-globins‚ which can each take or remove a molecule of oxygen. If a copy of the mutation is given by both parents‚ only defective beta-globins will be produced. These beta-globins will latch onto each other instead of to oxygen‚ and the hemoglobin molecule will link up with other hemoglobin molecules that have the same issue. This will cause the sickle shape in the cell
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Understand (comprehension) REF: eTable 30-1 TOP: Nursing Process: Assessment MSC: NCLEX: Physiological Integrity 3. A nurse reviews the laboratory data for an older patient. The nurse would be most concerned about which finding? a. Hematocrit of 35% b. Hemoglobin of 11.8 g/dL c. Platelet count of 400‚000/µL d. White blood cell (WBC) count of 2800/µL ANS: D Because the total WBC count is not usually affected by aging‚ the low WBC count in this patient would indicate that the patient’s immune function may
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affects about 3.5 million Americans (medweb). It is an illness that occurs when blood does not have enough healthy red blood cells or hemoglobin. Hemoglobin is an iron-rich protein that gives blood its red color (Geretsen). This protein helps red blood cells carry oxygen from the lungs to the rest of the body. Cells in the body do not get enough oxygen if hemoglobin is abnormal or if there are too few abnormal red blood cells. Symptoms then occur because your organs are not getting what they need
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cell disease is caused by a mutation in the HBB gene located on chromosome 11. Hemoglobin in red blood cells is how oxygen is delivered to cells throughout the body and is composed of four subunits‚ two subunits of alpha- globin and two of beta- globin. The HBB gene provides the instructions for making beta- globin. Sickle cell disease occurs when the HBB gene produces an abnormal version of beta- globin known as Hemoglobin S and replaces the original beta- globin subunit with the new version. These
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This Protein Missing or Defective* Enzyme Lactase (breaks down lactose) Lactose intolerance (difficulty digesting milk) Enzyme for synthesizing melanin (pigment that gives our skin and hair color) Albinism (very pale skin and hair) Transport Hemoglobin
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SYNTHETIC BLOOD This is an artificial blood made up of synthetic blood products. 1. The two main types of non-cellular blood products are hemoglobin based and Perfluorocarbon (PFC) based. a. Hemoglobin The hemoglobin-based substitutes use hemoglobin from several different sources: human‚ animal‚ and recombinant. Human hemoglobin is obtained from donated blood that has reached its expiration date and from the small amount of red cells collected as a by-product during plasma donation.
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Zellers Sickle cell disease is an autosomal recessive genetic disorder most common in African Americans‚ which results from a mutation affecting the amino acid sequence of the beta chains of hemoglobin molecules in red blood cells. The abnormal hemoglobin which causes the red blood cells to sickle is called hemoglobin S. Sickling occurs when the red blood cells are deoxygenated causing the cell to have a hard curved crescent shape. Due to their shape the sickle cells can become trapped in blood vessel
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the abnormal formation of the hemoglobin protein in red blood cells (Nih). Hemoglobin is an essential protein that resides within the red blood cells supplying oxygen to the entire body. Hemoglobin S causes a mutation in shape of hemoglobin protein causing a group of blood disorders including sickle cell anemia and thalassemia. Sickle cell anemia is a result of one abnormal hemoglobin S gene given to a child by each parent‚ children that inherit two abnormal hemoglobin S genes express the sickle cell
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replete iron stores in addition to correcting the anemia. Hypochromia means that the red blood cells have less color than normal when examined under a microscope. This usually occurs when there is not enough of the pigment that carries oxygen (hemoglobin) in the red blood cells. The most common cause of hypochromia in the United States is iron deficiency.1 Problem2 1. Teach client and family about CHF and its causes: Teaching reinforces the need to comply with
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