Analysis of Glycated Hemoglobin by HPLC Technology Shalini Kini Product Specialist Diabetic EpidemiologyWhere Do we Stand!?! World Scenario * IDF Diabetes Atlas 5th Edition 2012 update. http://www.idf.org/diabetesatlas/5e/Update2012 Did U Know!!??! One Adult in Ten will have diabetes by 2030!!! Year 2012 Year 2030 63.01m India 101.2m India • India Ranked Second in the world in Diabetes Prevalence‚ behind China. *IDF Diabetes Atlas- Fifth Edition http://www.idf
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Paul Manggahas‚ Luis Manio‚ Love Joy Masigan‚ Stephanie Kyra Mendiola‚ Roxanne Mendoza‚ Jullienda August 2014 I. Structure Myoglobin is almost similar in structures with hemoglobin except on the heme groups attached to it and to the presence of amino acids. Myoglobin only seems like a quarter of hemoglobin. Myoglobin has a molecular weight of 18‚ 000. It has a component of a single polypeptide chain folded into 8 α- helical structure‚ 153 amino acids and one heme group attached at the
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(CO2)|18||17-31|| Chloride (Of)|110||98-108|| Cholesterol||||| Creatine Phosphokinase (CPK or CK-MB)||||| Creatinine|0.30||0.1-0.7|| Ethyl Alcohol content (ETON)||||| Glucose|81||55-110|| Glutamyl Transpeptidase Test (GOT)||||| Glycosylated Hemoglobin (Hb A1c)||||| High-density Lipoprotein (HDL)||||| nomocysteine||||| Hormone Test||||| Iron (Fe)||||| Lactate Dehydrogenase (LDH)||||| Lipase||||| (*) Tests|Patient Results&Date|Patient Results &Date|Normal|Possible causes for out of
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concerned with the metabolic consumption of oxygen. Four distinctly colored groups of respiratory pigments exist among invertebrates: hemoglobins (purple‚ become orange-red with oxygen)‚ chlorocruorins (green‚ become red with oxygen)‚ hemocyanins (colorless‚ become blue with oxygen)‚ and hemerythrins (colorless‚ become red with oxygen). Formerly‚ invertebrate hemoglobins were called erythrocruorins to distinguish them from functionally similar yet structurally distinct pigments of vertebrate bloods.
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Stem Cell Research Adult stem cell research is providing opportunities to treat people with a various diseases and conditions. In 2010‚ a man’s ankle refused to heal so the doctor took bone marrow from the man’s pelvic bone with a needle‚ condensed it to about four teaspoons of rich red liquid‚ and injected that into his ankle. Four months later‚ the ankle was healed! Adult stem cells are found in all tissues of the growing human being and‚ according to latest reports‚ also have the potential
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carried in red blood cells by a substance called hemoglobin(Hemoglobin is the main substance of the red blood cell. It helps red blood cells carry oxygen from the air in our lungs to all parts of the body). Normal red blood cells contain hemoglobin A. Hemoglobin S and hemoglobin C are abnormal types of hemoglobin.Oxygen is carried in red blood cells by a substance called hemoglobin.The main hemoglobin in normal red blood cells is hemoglobin A. Normal red blood cells are soft and round and
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Hematologic Problems Anemia Definition Anemia is a deficiency in the number of erythrocytes (red blood cells RCB)‚ the quantity of hemoglobin‚ and/or the volume of packed RBCs (hematocrit). Because RCBs transport oxygen‚ erythrocytes disorders can lead to tissue hypoxia. Anemia is not a specific disease. It’s a manifestation of a pathologic process. Once anemia is identified‚ further investigation is done to determine its cause. Anemia can result from primary hematologic problems or can develop
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HEMOGLOBIN & MYOGLOBIN Protein Function HEMOGLOBIN: WHEN THE FIRST SUBUNIT OXYGENATES OR DEOXYGENATES THE FOLLOWING THREE SUBUNITS FOLLOW SUIT AND THE SHAPE OF THE HBG MOLECULE IS CHANGED. Oxygenated • R state (relaxed) • When O2 is present‚ it binds to the iron attached to each heme and tugs on it which in turn flattens the heme to a planar shape • The color of oxygenated blood is red (macroscopic) • Carried from the heart throughout the body by the systemic arteries Deoxygenated
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Disease‚ is a disease that causes the production of abnormal hemoglobin. The red blood cells (RBCs) carry oxygen to organs and tissues. Hemoglobin‚ a molecule in the RBCs‚ is a protein that attaches to the oxygen in the lungs and carries it to all parts of the body. Hemoglobin takes on the oxygen‚ and releases carbon dioxide‚ a process known as oxygenation. In the tissues‚ deoxygenation occurs where the processes is reversed‚ when hemoglobin releases oxygen and takes on carbon dioxide. When the RBCs
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Anemia ABSTRACT The purpose of this paper is to briefly describe the initial core diagnostic questioning and core set of diagnostic testing related to the patient presenting with anemia. Subjective information and recommended testing are written with consideration of the scope of practice of the family nurse practitioner. In addition‚ three specific case studies are examined. Anemia Core set of subjective questions The healthcare provider should initially obtain a history of any previous
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