Introduction to IMMUNOLOGY COURSE • Subject Agenda* Theoretical part (Lecture): 14.01----18.03----22.04.2013 Practical part (Labwork) • Study Materials: Textbook (David Male and Ivan Roitt-2006-DIR; Abul Abbas-2007AA)‚ Clips and Internet search • Classconversation@gmail.com. Pass: btiu12345 • Evaluation - Midterm Exam‚ Final Exam‚ Labwork - Assignment (Home-work‚ Topic-oriented-In-class discussion‚ Readand-Present Practice) Contact me at: R501‚ IU Building; or via email: ntthoai@hcmiu.edu
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85326 Lecture 5 Role of transmembrane signaling in immunorecognition (signal transduction) G Ligand (primary 0 messenger) 0.0 shapeType75fBehindDocument1pWrapPolygonVertices8;18;(8674‚879);(15125‚879);(15125‚145);(21500‚145);(21500‚1540);(14509‚1540);(14509‚21497);(3531‚21497);(3531‚19296);(3607‚19296);(3607‚15187);(2071‚15187);(2071‚2713);(0‚2713);(0‚0);(3223‚0);(3223‚806);(8674‚806)posrelh0posrelv0pib Receptor-ligand binding CYTOSOL Cellular responses Signal
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Title: Immunology Aim: To visit a microbiology department at the university hospital and acquire detailed information of various antigen-antibody tests eg. ASO‚ haemotoglutination‚ ELISA etc. Method: To listen to presentation made and thus formulate a concise report on that which was discussed and demonstrated. (Please see BC34D Laboratory Manual for more information) Concise Report/Summery: The term serology refers to both the study of general antigen-antibody reactions in a laboratory
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Innate Targeting of Pathogens Pathogen Examples Facts Pattern recognition alerted by Viruses flu‚ small pox‚ HIV‚ polio‚ Ebola‚ rhinovirus‚ hepatitis‚ measles Can only reproduce inside cells Foreign nucleic acids (double stranded RNA‚ single stranded DNA‚ foreign methylation patterns)‚ reduced antigen presentation by infected cells So viruses are usually recognized by something unusual in their nucleic acids.(Double RNA‚ normally‚ RNA is a single strain) Bacteria
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Papa Kwame Pireku Problem set 1 2.2) Antimicrobial peptides are usually produced as inactive propeptides that require cleavage by a protease to complete their activation‚ often by generating a cationic peptide that takes on an amphipathic structure capable of disrupting the cell membrane of a microbe. Also in neutrophils the antimicrobial agents are activated by proteolytic cleavage when these granules fuse with phagosome and encounter neutrophil elastase that has been released from primary granules
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NEUTROPHILS & MACROPHAGES: Neutrophils & Macrophages play the main role in (SEEK AND DESTROY) the invading agents (microbes‚viruses and other injurious agents) NEUTROPHILS are mature cells that can SEEK AND DESTROY agents even in BLOOD ‚ MACROPHAGES begin their life as immature cells in blood called monocytes ‚ when they enter the tissues they swell and become mature and named MACROPHAGES which are extremely capable of SEEK AND DESTROY intratissue injurious agents. White Blood Cells Enter the
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8536d_ch01_001-023 8/1/02 4:25 PM Page 1 mac79 Mac 79:45_BW:Goldsby et al. / Immunology 5e: Overview of the Immune System chapter 1 T defense system that has evolved to protect animals from invading pathogenic microorganisms and cancer. It is able to generate an enormous variety of cells and molecules capable of specifically recognizing and eliminating an apparently limitless variety of foreign invaders. These cells and molecules act together
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Unit 10: Blood/Immunology Case Study Lab What were your three diagnoses? 1. Case 1: Pernicious Anemia 2. Case 2: Normal Blood Smear 3. Case 3: Malaria Journal Questions for lab 1. In what ways do normal red and white blood cells differ? Many red blood cells circulate in the bloodstream‚ while the white blood cells leave the blood. 2. Which type of white blood cell would you expect to be most common in a normal blood smear? Neutrophils 3. A differential
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MEDICAL IMMUNOLOGY & SEROLOGY Terence L. Eday‚ RMT‚ MT(ASCPi)‚ MPH College of Medical Technology / Medical Laboratory Science University of Perpetual Help System DALTA Historical Perspective • 1773‚ Voltaire reported on an ancient Chinese custom where dried and powdered small pox scabs were inhaled • 1798‚ Edward Anthony Jenner‚ Smallpox vaccination • 1862‚ Ernst Haekel‚ Recognition of phagocytosis • 1877‚ Paul Erlich‚ recognition of mast cells Historical Perspective • 1879‚
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Immunology is defined as a science that deals with the immune system and the cell-mediated and humoral aspects of immunity and immune responses. An immunologist deals with humans that have an immune response that is not considered normal. For example they treat patients’ that have AID’s‚ Immunodeficiency’s‚ and some autoimmune disorders. Immunology began when Edward Jenner developed a vaccine for small pox‚ and lead to a system of programs to immunize people‚ though this is not all immunologists
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