In 1956‚ Denham Harman articulated the free radical theory of aging which states that ‘oxygen free radicals that are formed endogenously in live cells result in a pattern of cumulative damage’(9). The theory is also implied that the target of those radicals in the cellular system is random. In live cells‚ DNA‚ protein and lipid are targets for the free radical’s invasion. Damaging any of those vital macromolecules in live cell affects the physiology of the cell and may lead to apoptosis and cell
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very controversial; especially embryonic stem cell research. Many debate over the ethics of the research versus the medical advantages. The medical advantages outweigh the ethical views. The mass of embryonic stem cells that are used come for in vitro fertilization (IVF) (Black). Those cells are disposed as medical waste—using them for research gives those cells a purpose and to be wasted (16). Embryonic stem cells can regenerate into nerve cells which can solve brain diseases such as Parkinson’s
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Experiments on animals are cruel and expensive. New scientists are developing methods that replace animals. The tests use human cells and tissue (known as in-vitro methods)‚ computer modeling techniques (known as in-silico methods)‚ and studies with human volunteers. The new experiments take less time and money to complete. The primary use of in-vitro tests is to detect specific toxic properties of drugs and/or chemicals. The studies normally take place in labware such as test tubes‚ flasks‚ petri dishes
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process of deriving the new drug starts in the laboratory. The chemical formula of the drug are composed in the lab and also called as the vitro testing. This type of testing performed before the drug can be tested on the animals or humans. The vitro testing gives the chemical description of the new drug and formulates the base and additional supplements. After vitro testing is done‚ the vivo testing starts on the animals. This process includes testing to figure out the possible side effects‚ level of
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More specifically‚ it looks at the effects of quercetin on exercise performance and how it may be beneficial in increasing endurance tolerance through both in vitro and in vivo studies. Davis et al. finds that quercetin is able to increase mitochondrial biogenesis as well as act as an antagonist to the adenosine A1 receptor‚ thus delaying fatigue and up-regulating dopamine release. The review article also discusses
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A PATIENT EDUCATION DOCUMENTARY Rebecca M. Butler Mrs. Patricia Lamb HCA-220 May 31st‚ 2015 Objective Define polycystic ovary syndrome. Identify risk factors of polycystic ovary syndrome. Describe the signs and symptoms of polycystic ovary syndrome. Describe the common diagnostic measures used in polycystic ovary syndrome. Describe the common treatment interventions for polycystic ovary syndrome. Discuss the preventative measures for polycystic ovary syndrome. Discuss women who
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87‚ 88 showed strong inhibition activity both to topo II & topo I [54]. Chen et al.‚ 2013 synthesized N-(naphthalen-2-yl)acetamide and N-(substituted phenyl)acetamide bearing quinolin-2(1H)-one and 3‚4-dihydroquinolin-2(1H)-one derivatives and in vitro antiproliferative activities against a panel of human cancer cell lines including nasopharyngeal (NPCTW01)‚ lung carcinoma (H661)‚ hepatoma (Hep3B)‚ renal carcinoma (A498)‚ and gastric cancer (MKN45) was done. Compound 89
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Cent. Eur. J. Biol. • 8(10) • 2013 • 943-957 DOI: 10.2478/s11535-013-0209-6 Central European Journal of Biology New perspectives on antibacterial drug research Review Article Joanna Ziemska‚ Aleksandra Rajnisz‚ Jolanta Solecka* Laboratory of Biologically Active Compounds‚ National Institute of Public Health - National Institute of Hygiene‚ 00-791 Warsaw‚ Poland Received 14 March 2013; Accepted 10 May 2013 Abstract: Bacterial resistance to commonly used antibiotics is constantly
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177 Global Journal of Medicinal Plant Research‚ 1(2): 177-183‚ 2013 ISSN 2074-0883 Assessment of the safety of tawa-tawa (Euphorbia hirta L.) decoction as alternative folkloric medicine 1 Sharon Rose M. Tabugo‚ 1Rolliebert B. Rampola‚ 2Edgar Vasallo Jr.‚ 1Ma. Reina Suzette B. Madamba 1 Department of Biological Sciences‚ College of Science and Mathematics‚ MSU-Iligan Institute of Technology‚ Iligan City; 2 Capitol University‚ Cagayan de Oro City ABSTRACT Euphorbia hirta
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theEudragit RSPO membrane in different concentrations was cast to achieve controlled release of the drug. The absence of physiochemical interactions between VFH and the polymers was confirmed by FT-IR spectroscopy. The physicochemical parameters and in-vitro drug release studies of formulations were performed and data of optimised formulation was fitted to various kinetic models. The results indicated that suitable tri-layered transdermal patches of VFH with controlled drug release
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