Merck is a global research-driven pharmaceutical company dedicated to putting patients first. Merck’s highest priority areas are Alzheimer’s disease‚ atherosclerosis‚ cardiovascular disease‚ diabetes‚ novel vaccines‚ obesity‚ oncology‚ pain and sleep disorders. In addition‚ and importantly for licensing‚ the following other areas remain of high interest for focused investment in new compounds and mechanisms: antibiotics‚ antifungals‚ antivirals (HCV and HIV)‚ asthma‚ COPD‚ neurodegeneration‚ ophthalmology
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Several studies reported that GDF15 induction is associated with apoptosis and cell cycle arrest (-). Hence‚ GDF15 may be an excellent in vivo biomarker of the activation of p53 pathway
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Even though N20 directly depresses myocardial contractility in vitro‚ arterial blood pressure‚ cardiac output‚ and heart rate are essentially unchanged or slightly elevated in vivo because of its stimulation of catecholamines. (Respiratory) N20 increases respiratory rate (tachypnea) and decreases tidal volume as a result of CNS stimulation and activation of pulmonary stretch receptors. The net effect is minimal change in minute
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Bastards not begotten in adultery or incest are not prohibited from taking under their parents’ will or deed; and since the passing of Ordinance No. 21 of 1844 a father may leave all his property to such illegitimate children either by will or act inter vivos to the exclusion of his legitimate ones. Held by Bonser‚ C.J.‚ and Withers‚ J.‚ dissenliente Lawrie‚ J.‚ that Ordinance No. 6 of 1847 does not contain the whole law of marriage in force in Ceylon‚ and that the Roman-Dutch Law is still in force in
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Cognitive Behavioral Therapy (CBT) Cognitive behavioral therapy (CBT) is a psychotherapeutic approach that addresses dysfunctional emotions‚ maladaptive behaviors and cognitive processes and contents through a number of goal-oriented‚ explicit systematic procedures. The name refers to behavior therapy‚ cognitive therapy‚ and to therapy based upon a combination of basic behavioral and cognitive principles and research. Most therapists working with patients dealing with anxiety and depression use
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Concert Review 1 Jazz Concert The concert I attended stared two very talented African musicians‚ Lionel Loueke and Richard Bona. This was the first concert I had ever been to. I had never seen professional artists perform live before so seeing these two men that were well known in the jazz world was amazing. It was nothing like I expected‚ I thought the concert was just going to be regular old jazz songs‚ but the way these guys played it was like they were free styling the entire show. The musician
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ATP Synthase: The World’s Smallest Motor Adenosine triphosphate (ATP) is a coenzyme produced in cellular mitochondria and is not only integral to cellular metabolism but also to life. The mitochondrial production of ATP‚ which occurs through a complex process called oxidative phosphorylation‚ has been determined to rely heavily on the enzyme ATP synthase. This determination was the result of a complex experiment that attempted to prove not only that ATP synthase was responsible for production
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Hypersensitivity ■ Exaggerated responses by an individual to an antigen following a previous exposure ■ Ag-ab reaction – release large quantities of chemicals‚ enzyme‚ and cell stimulators that are damaging to the host. ■ Traditionally classified based on time after exposure to offending antigen ❑ Immediate hypersensitivity – Ab mediated ❑ Delayed hypersensitivity – Cell mediated Types of Hypersensitivity Type I - ANAPHYLACTIC Type
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INTRODUCTION Give a brief description in your own words of the objectives and aims of this practical. The aim of this practical is to investigate how the autonomic nervous system (ANS) affects the motility in the gastrointestinal tract‚ by experimenting with the release of neurotransmitters. A. RESPONSES TO NERVE STIMULATION Attach a copy of your experimental recordings showing a period of spontaneous contractions and the response to stimulating the nerves
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The Cystic Fibrosis Foundation describes Cystic Fibrosis as “a progressive‚ genetic disease that causes persistent lung infections and limits the ability to breathe over time” (www.cff.org). People with Cystic Fibrosis suffer from an increase of mucus buildup in the lungs‚ pancreas‚ and the liver; Cystic Fibrosis also affects the Nose and sinuses‚ as well as the sweat glands. The only way that CF is transmitted is by a Cystic Fibrosis positive carrier. When two positive carriers have a baby there
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