PH 131 BIOCHM FNDTN THERAPEUTICS DR. JOSEPH 1. Select the predominant form of Amoxicillin (shown above) at pH 5.3. The pKa of the phenolic -OH is 9.6‚ the NH3+ is 7.4‚ and the COOH is 2.4. 2. At what pH would amoxicillin most readily cross a chloride channel? A. 1.8 B. 5.7 C. 8.0 D. 10.5 E. 3.6 3. Using the pK values shown in parentheses in the above diagram‚ select the pI of the tripeptide Arginiyltyrosinylcystyl from the following choices: A. 11.6 B. 5.0 C. 5.6
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This phrase tells us that they are better not to invest in light beer because it is very unprofitable for the company. Also‚ if we looked at exhibit 2‚ the sales of Boston lightship were decreasing gradually from 1992 to 1997. 2. I agree with the HBS team recommendation. I think Amstel Light was very successful in the light beer product‚ so it is a good idea to have the same target segment. My perception is BBC is categorized as a newbie in the light beer category and we all know that it is very
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The movement of water down its osmotic gradient across a selectively permeable membrane is known as osmosis. The difference in the concentrations of solutes on either side of the membrane results in the establishment of an osmotic pressure. Water follows the direction of solutes‚ this means that in the event where there are more solutes outside the cell than there are inside the cell‚ water will move from the inside of the cell to the outside in order to establish water balance. When a cell is placed
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Peter Drucker‚ in his article of HBS discusses the sources and types of innovation and analyzes through examples where different types of innovations stand. Firstly he asks the question whether innovation is hard work or as believed by many inspiration. He argues that innovation is mostly the resuly of hard‚ disciplined work as opposed to inspiration. Then he goes on to discuss the profile of innovative organizations and their managers. He thinks that establishing roles and processes‚ setting goals
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Table 5: Characteristics of human and bovine red blood cells HUMAN MALE HUMAN FEMALE COW WBC COUNT(#of cells/mm^3 of blood) 7000 7250 7450 RBC COUNT(# of cells/mm^3 of blood) 540000 4600000 8000000 HEMATOCRIT (%) 47 42 37 [Hb](g/100ml of blood) 16 14 12 MCV (femtoliters) MCHC(%) 34 33 32 MCH(pinograms) Discussion: 1. RBC count‚ hemotocrit and hemoglobin concentration are higher in males than females. It is because males generally have larger muscle mass and perform more physical
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THE PROBLEM AND ITS SETTING Introduction Nikola Tesla‚ Sir Albert Einstein‚ former Republic of the Philippines President Ferdinand Marcos‚ and Dr. Jose Rizal‚ they all have one thing in common – a nanay-teacher. The nanay-teacher was a house bill (HB No. 5243) first introduced by Hon. Sherwin Gatchalian‚ a Congressman in Valenzuela City. This act was intended to strengthen the role of parents as partners of the government in educating children. Most Filipino students have their mothers at home
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Engineering Materials Week 3 5.1 Briefly explain the difference between self-diffusion and interdiffusion. Self-diffusion refers to movement of atoms within a pure material; interdiffusion refers to the movement of one or more kind of atoms in a heterogeneous system. 5.7 A sheet of steel 2.5mm thick has nitrogen atmospheres on both sides at 900C and is permitted to achieve a steady-state diffusion condition. The diffusion coefficient of nitrogen in steel at 900 C is 1.2 10^-10 m^2/s‚ and the diffusion
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Cola wars continue: Coke and Pepsi in 2010 (HBS 9-711-462) a. Use the 5-forces framework to explain why the soft drink concentrate industry has been so profitable. The soft drink concentrate industry has been very profitable for over 100 years. The reason can easily be found by analyzing the concentrate industry using the 5-forces model. According to the 5-forces model‚ each industry’s profitability can be assessed considering the five forces that influence the market – The rivalry among existing
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Outsourcing is the contracting of a business process by another party. Outsourcing sometime involves transferring employee and assets from one firm to another. It can be foreign or domestic contracting and sometimes involves moving a business to another country. Financial savings from lower international labor rates can provide the biggest motivation for outsourcing. Companies will outsource for many reasons. The first reason is time‚ theoretically no company has the time to take care of everything
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