Biochemistry of Muscle Contraction Fred P. Guillergan M.D.‚ FPCP Outline histology and biochemistry of muscles (Striated & smooth) – Myosin – Actin‚ Tropomyosin‚ Troponin – Accessory proteins of muscles Biochemical events in muscle contraction Calcium‚ Ca2+-binding proteins and Ca2+ channels in muscle contraction Biochemistry of Cardiac & Smooth muscle contraction Energetics of muscle contraction ☻Able to understand the normal anatomy and physiology of different types of muscles
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Lab 6: Amphibian Muscle Contraction Results: For this experiment‚ Isometric contractions of the gastrocnemius muscle of a frog were analyzed and from this data the latent period‚ twitch‚ motor unit summation‚ tetanus‚ fatigue & mechanical summation were measured. The data was used to quantify the effect of passive tension on the twitch force‚ effect of stimulus intensity on the twitch force‚ effect of stimulus frequency on contractile force of xenopus gastrocnemius muscle. The threshold voltage
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Fitness‚ and Nutrition A Muscle Contraction Muscle Contraction is part of an organ in the body that is tensive. It may have a process of tensions that may be developed with muscle tissues. Contraction can be a meaning of shortening or long. Muscle Contraction can also produce a muscle cell that is for movement of the body. Myosin and Actin is an interaction protein to Muscle Contraction‚ it can be changed by shape but not by volume. Skeletal Muscle contraction is produce by heat. The muscles may
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ACTIVITY 1: THE RESTING MEMBRANE POTENTIAL 1. Explain why increasing extracellular K+ reduces the net diffusion of K+ out the neuron through the K+ leak channels? When the diffusion is greater on one side‚ the other side will slow down. 2. Explain why increasing extracellular K+ causes the membrane potential to change to a less negative value. How well did the results compare with your predictions? There are two potassium’s for every sodium so the increase of potassium will make it more
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There are three phases for muscle cell contraction: initiation of action potential in the sarcolemma‚ excitation-contraction coupling‚ and contraction‚ sliding of the myofilaments. ATP and calcium ions are two essential elements for muscle contraction. When ATP attaches to the myosin head‚ it gets hydrolyzed to ADP and Pi. Calcium ions bind to the troponin molecules and help expose the binding sites of actin filaments to allow for the attachment of the myosin heads. After the sliding of the myofilaments
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acetylcholine‚ adrenaline and atropine‚ and increased frequency of stimulus. Regarding Figure 1‚ the regular heartbeat and contraction force of the toad was identified to demonstrate the difference between atrial contractions and ventricular contractions in a normal environment. In cardiac‚ skeletal‚ and some smooth muscle tissue‚ contraction occurs through a spectacle known as excitation contraction coupling (Freeman et al.‚ 2014). This process converts electrical stimulus from the neurons into a mechanical
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Purpose: The purpose of this lab is to test what substances are necessary for muscle contraction. Hypothesis: Based off the frog muscle immersed separately in Solution A of ATP and distilled water solution‚ Solution B of ATP with KCl in distilled water and MgCl2 in distilled water and solution C of KCl and MgCl2 in distilled water‚ I hypothesize that solution B of ATP with KCl in distilled water and MgCl2 in distilled water will cause the muscle to contract. Introduction: This lab consisted of
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filaments must slide past one another (Widmaier 2011). Muscle fibers are innervated by motor neurons. A motor unit is a single motor neuron and all muscle fibers it innervates. Contraction occurs through a mechanism called excitation-contraction coupling when an action potential propagates down a motor neuron axon to initiate contraction. As the action potential then travels down these transverse tubules it opens ion channels‚ which releases calcium into the sarcoplasm. When this calcium is released‚ binding
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EXERCISE 9: RENAL SYSTEM PHYSIOLOGYHere is 9 got 95% Still need help on final 132 | ACTIVITY 1: The Effect of Arteriole Radius on Glomerular Filtration Answers 1. According to your lab manual‚ in humans the glomerular filtration rate (GFR) ranges from _____ to _____ ml/minute. 80 140 2. When the radii of both the afferent arteriole and efferent arteriole were set at 0.45mm‚ the GFR was approximately ______ ml/minute. a. 40 b. 60 c. 80 d. 120 C. 3. True or
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Exercise 3: Neurophysiology of Nerve Impulses: Activity 7: The Action Potential: Conduction Velocity Lab Report Pre-lab Quiz Results You scored 100% by answering 5 out of 5 questions correctly. 1. An action potential can be propagated along an axon because there are __________ channels in the membrane. You correctly answered: d. voltage-gated 2. The units of conduction velocity are You correctly answered: d. meters/second. 3. Which of the following will affect axonal conduction velocity? You correctly
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