IUBMB Life‚ 53: 85–98‚ 2002 Copyright c 2002 IUBMB 1521-6543/02 $12.00 + .00 DOI: 10.1080/10399710290038972 Review Article Structural Basis of Perturbed pKa Values of Catalytic Groups in Enzyme Active Sites Thomas K. Harris1 and George J. Turner2 Department of Biochemistry and Molecular Biology‚ University of Miami School of Medicine‚ Miami‚ Florida 2 Department of Physiology and Biophysics and the Neurosciences Program‚ University of Miami School of Medicine‚ Miami‚ Florida 1 Summary
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1. GENESIS OF ‘THE GOAL’ The Goal is about science and education. The author believes that these two words have been abused to the extent that their original meanings have been lost in a fog of too much respect and mystery. Science for him is not about the secrets of nature or even about truths. Science is simply the method to try and postulate a minimum set of assumptions that can explain‚ through a straightforward logical derivation‚ the existence of many phenomena of nature. For example the
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Constraint Management at UniCo: Analyzing “The Goal” as Fictional Case Study Abstract As a fictional case study‚ Eliyahu Goldratt’s novel about manufacturing‚ “The Goal: A Process of Ongoing Improvement‚” presents a constraint-focused approach to production management. As a novel‚ the book does not emphasize the quantitative details of the plant improvements. However‚ a great amount of information about the plant is spread throughout the book. By collecting and analyzing this
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Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa Noriko Umegaki-Arao et al. Sci Transl Med 6‚ 264ra164 (2014); DOI: 10.1126/scitranslmed.3009342 Editor ’s Summary Epidermolysis bullosa (EB) is a rare‚ inherited skin disorder that causes such severe blistering that patients are often relegated to a delicate life in bandages. Like a patchwork quilt‚ the skin of a patient with EB can consist of both mutated skin cells (which cause the disease)
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89. Kato K‚ Cox AD‚ Hisaka MM‚ Graham SM‚ Buss JE‚ Der CJ. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci USA 1992;89(14):6403–7. 90. Kijima H‚ Yamazaki H‚ Nakamura M‚ Scanlon KJ‚ Osamura RY‚ Ueyama Y. Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer. Int J Oncol 2004;24(3):559–64. 91. Coffey MC‚ Strong JE‚ Forsyth PA‚ Lee PW. Reovirus therapy of tumors with activated Ras pathway
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Christian Schindler lnga Strehlow Departments of Microbiology and Medicine College of Physicians and Surgeons Columbia University New York‚ NY 10032 Cytokines and STAT Signaling 1. Introduction First discovered as the major signal transducer in interferon-mediated gene activation‚ STATs (signal transducers and activators of transcription) are now known to play a significant role in signal transduction for most cytokines. STATs represent a family of conserved proteins‚ seven of which have
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Bioresource Technology 79 (2001) 207±225 Review paper The production of poly-(c-glutamic acid) from microorganisms and its various applications Ing-Lung Shih *‚ Yi-Tsong Van Department of Environmental Engineering‚ Da-Yeh University‚ 112 Shan-Jiau Road‚ Da-Tsuen‚ Chang-Hwa 51505‚ Taiwan‚ ROC Accepted 9 April 2001 Abstract This review article deals with the chemistry and biosynthesis of poly-(c-glutamic acid) (c-PGA) produced by various strains of Bacillus. Potential applications of
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Democracy as a Universal Value Amartya Sen Copyright © 1999 National Endowment for Democracy and the Johns Hopkins University Press. All rights reserved. Journal of Democracy 10.3 (1999) 3-17 In the summer of 1997‚ I was asked by a leading Japanese newspaper what I thought was the most important thing that had happened in the twentieth century. I found this to be an unusually thought-provoking question‚ since so many things of gravity have happened over the last hundred years. The European empires
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1. Kaneka Corporation – Company Profile‚ SWOT & Financial Report Kaneka Corporation TABLE OF CONTENTS 1 Kaneka Corporation - Key Employees ............................................................................................................7 2 Kaneka Corporation - Major Products and Services .................................................................................. 8 3 Kaneka Corporation - History ..........................................................................
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Chapter 2 Integrin Structure and Function Manakan Betsy Srichai and Roy Zent Abstract Integrins are a large family of heterodimeric glycoprotein receptors first discovered over twenty years ago. They exist as two noncovalently bound a- and b- subunits that function as adhesion molecules and play key roles in many biological processes including actin cytoskeleton organization and transduction of intracellular signals regulating cellular functions. Integrins bind a variety of extracellular matrices
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