Oncotarget‚ November‚ Vol.1‚ No 7 www.impactjournals.com/oncotarget/ Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Joshua C. Curtin and Matthew V. Lorenzi 1 Oncology Drug Discovery‚ Research and Development‚ Bristol-Myers Squibb‚ Princeton‚ NJ‚ USA Correspondence to: Matthew V. Lorenzi‚ e-mail: Matthew.Lorenzi@bms.com Keywords: oncotarget‚ cancer‚ stem cells‚ wnt‚ drug discovery Received: August 8‚ 2010‚ Accepted: October 27‚ 2010‚ Published: October 30‚
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up from metal-containing clusters connected by multidentate organic linkers1‚2. MOFs are attracting considerable attention due to the possible rational design of crystal structures of coordination frameworks with versatile metal ions and organic ligands. In principle‚ MOFs topologies along with intermolecular distances between various building blocks can be controlled using the fundamentals of reticular chemistry. This offers a great potential for tailoring MOFs properties for a wide scope of high-tech
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Fe(NH4)2(SO4)26(H20) had 4 unpaired electrons‚ KMnO4 had zero unpaired electrons‚ and K3[Fe(CN)6] had 1 unpaired electron. The apparent 1 unpaired electron in K3[Fe(CN)6] when there should be five according to atomic orbital calculations arises from a strong ligand field produced by CN-. Introduction: The magnetic susceptibility is a phenomena that arises when a magnetic moment is induced in an object. This magnetic moment is induced by the presence of an external magnetic field. This induced magnetic moment
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Introduction to the Lanthanides r understand that lanthanides differ in their properties from the s- and d-block metals; r recall characteristic properties of these elements; r appreciate reasons for their positioning in the Periodic Table; r understand how the size of the lanthanide ions affects certain properties and how this can r understand how to obtain pure samples of individual Ln3+ ions. 1.1 Introduction Lanthanide chemistry started in Scandinavia. In 1794 Johann Gadolin succeeded in
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acid-base reaction in which neutral molecules bond to a central metal atom by coordinate covalent bonds. A coordinate covalent bond is a covalent bond in which one atom supplies both electrons. Ligands are atoms or molecules with electron pairs available‚ and they may be neutral or negatively charged. Ligands are usually thought of as electron donors attracted to the metal at the center of the complex. Isomers are different compounds with the same molecular formula. Also‚ isomers can be recognized
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obtaining both cytotoxicity and cytokine-producing effector functions (Trinchi-eri‚ 1989). NK cells circulate and patrol the blood system and are activated via cytokine signalling or up-on encountering target cells that express NK cell receptor ligands (Lanier‚ 2005). Lytic activity subse-quently proceeds against the infected or altered host cell (Gonzales et al.‚ 2012). There are
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[73-75] when bifunctional ligands with two donors atoms are used‚ the gold atom will bind to these ligands through the atom with the higher donor strength according to the sequence Si~P> C > S >Cl> N > O > F. In other words‚ the two bifunctional are coordinated to gold through the P and S atoms but not N‚ since P and S are better soft donor than N [76]. Additionally‚ the gold is often described as a soft metal and therefore‚ might be expected to prefer soft donor ligands such as sulfur and carbon
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Journal of Luminescence 130 (2010) 2476–2486 Contents lists available at ScienceDirect Journal of Luminescence journal homepage: www.elsevier.com/locate/jlumin Spectroscopic and nano-molecular modeling investigation on the binary and ternary bindings of colchicine and lomefloxacin to Human serum albumin with the viewpoint of multi-drug therapy J. Chamani a‚n‚ A. Asoodeh b‚ M. Homayoni-Tabrizi a‚ Z. Amiri Tehranizadeh c‚ A. Baratian c‚ M.R. Saberi c‚ M. Gharanfoli d a Department of Biology‚ Faculty
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gene that causes the disorder. EFNB1 is the gene that encodes the transmembrane protein‚ ephrin-B1 and research has traced CFND to the activities of EFNB1. As a review from this week’s textbook reading‚ the ephrin family signaling proteins acts as a ligand and binds to and activates the Eph family of receptor tyrosine kinases (RTKs). The Eph family plays an important role in cell migration and when activated by ephrin‚ it is known to help motor neurons get to their target. However‚ with this disease
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profile of large scale units has been provided below. Sr. no. Establishment names Address Product total employee Particulars of employment Supervisory Non-supervisory Total emp. Local emp. % ELP Total emp. Local emp. % ELP 1 SUN PHAMACEUTICALS LTD. A-8 MIDC INDL AREA‚ A;NAGAR PHARMACEUTICALS 354 38 37 97 316 314 99 2 FORCAS IMPEX PVT. LTD. PLOT NO.G-18‚ MIDC‚ A’NAGAR VOLVE COMPONENTS 36 10 10 100 26 26 100 3 BIKSONS FORGE (INDIA) LTD. PLOT NO. B-11‚ MIDC‚ A’NAGAR IRON AND STEEL 26
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