hexanitrocobaltate (III) Date: 12 March 2014 INTRODUCTION Sodium hexanitrocobaltate (III) is a coordination complex which has the formula Na3[Co(NO2)6]. This compound is yellow in colour. It consists of a central Co3+ ion surrounded by six nitro ligands [1]. This compound is used as a qualitative test for potassium and ammonium ions (so long as certain other cations are not present) [1]. Potassium and ammonium are insoluble in water‚ while sodium is [1]. Hence‚ the potassium and ammonium salts are
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elucidate some of the biochemical pathways which they affect. Despite the intense controversy surrounding the subject‚ there have been quite a few breakthroughs in the past decade. The most notable being the identification of the endogenous cannabinoid ligand. In social and political discussions one often hears two extreme opinions on opposite ends of the spectrum with regard to this subject. Some people feel that marijuana is a dangerous drug which should be kept at its current status as a Schedule One
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DISCIPLINE OF PHARMACEUTICAL CHEMISTRY DRUG DESIGN AND DISCOVERY BY: xxxxxxx Introduction A drug is a substance that we used mostly in our daily lives. It is a chemical substance with physiological effects when ingested or introduced into our bodies. The response produce can either be beneficial or harmful. Toxins and poisons can be classified as drugs. This report the term ‘drug’ is for medicinal or pharmaceutical purposes. Drugs used to prevent or treat diseases. Drug design
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14 may be a possible EEC. Moreover‚ the calculated compensation temperature by inverting the straight line slope‚ T comp = 57.9 ºC‚ is higher than the average experimental value‚ T exp = 32.5 ºC. This great difference between these two values of temperatures might reflect the existence of real EEC rather than experimental error [58]. Another evidence of EEC is the approximate constant ∆G # with a significant change in both ∆H # and ∆S # . Finally‚ EEC was also investigated by using
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D24BT8 Structural Biology Essay - What is the future of structural genomics in academia and industry? Cera Wong April 3‚ 2013 Structural genomics (SG) programs were formed by development of structure biology in large scale. Targets were selected from a specific genome‚ topologically similar types of proteins or protein families. (REF: Maksymilian) SG programs have developed more accurate and efficient methodologies on structure determination over the last decade (REF: Maksymilian)‚ where many
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Receptors and Ligands: Examining the effects of pharmaceutical compounds on Daphnia magna physiology Abstract The following study was conducted in order to determine the effects of four different pharmaceutical compounds on the heart rate of Daphnia specimens. After basal heart rate was observed and computed‚ four different solutions each containing either an adrenergic‚ muscarinic‚ or nicotinic agonist or antagonist was tested against individual Daphnia. Observations were made through a compound
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al.‚ 1997; Yan et al.‚ 1996).JAKs are receptor-associated tyrosine kinases‚ which mediate the ligand dependent activation of STATs. These two protein families are the defining components of the JAK-STAT pathway. The JAK-STAT signaling paradigm (see Fig. 1)has been well characterized for many ligands (reviewed in Darnell‚ 1997; Ihle et al.‚ 1994; Schindler and Darnell‚ 1995). Briefly‚ upon binding ligand a receptor will dimerize. This enables receptor-associated JAKs to become activated‚ which in
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Available online at www.sciencedirect.com Nanomedicine: Nanotechnology‚ Biology‚ and Medicine xx (2011) xxx – xxx www.nanomedjournal.com Review Article Upconversion nanoparticles: synthesis‚ surface modification and biological applications Meng Wang‚ PhDa‚c ‚ Gopal Abbineni‚ MSb ‚ April Clevenger‚ MSb ‚ Chuanbin Mao‚ PhDb ‚ Shukun Xu‚ MSa‚⁎ a College of Sciences‚ Northeastern University‚ Shenyang‚ People’s Republic of China Department of Chemistry and Biochemistry‚ University of Oklahoma
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References: Sridhar Ramaswamy‚ M.D. Rational Design of Cancer-Drug Combinations‚ 2007. Drc :A Review of LigandScout‚ 2008 Wolber‚ G.; Langer‚ T.; LigandScout: 3-D Pharmacophores Derived from Protein-Bound Ligands and III trial. Joint Lung Cancer Study Group. Helsing M‚ Bergman B‚ Thaning L‚ Hero U Eur J Cancer. 1998 Jun; 34(7):1036-44. Kapetanoic‚I.M.‚ 2008. Computer aided Drug discovery and development: insilico-chemico-biological approach
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Abstract- Due to increase in the incidences of drug resistant pathogens‚ there is a need for the development of alternative drugs against which the microorganisms will not be able to develop resistance. The most promising candidates to be developed as alternative drugs are the antimicrobial peptides. In the present study the antimicrobial peptide Microcin C7 was docked with the catalytic domain of Diphtheria toxin and further the simulational studies were performed to find the stability of the complex
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