Chapter 3 Homeostatic Imbalances 3.1 Definite changes occur in the glycocalyx of a cell that is becoming cancerous. In fact‚ a cancer cell’s glycocalyx may change almost continuously‚ allowing it to keep ahead of immune system recognition mechanisms and avoid destruction. (Cancer is discussed on pp. 145-146) 3.2 Selective permeability is a characteristics of healthy‚ intact cells. When a cell (or its plasma membrane) is severely damaged‚ the membrane becomes permeable to virtually everything
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National technology day celebrated 11th May 1998 being the defining moment in the growth of technology prowess‚ was christened as National Technology Day by the then Prime Minister of India. Since then it is being celebrated every year as National Technology Day across the country by various scientific and industrial organizations and educational institutions. The event in New Delhi today was coordinated by the Ministry of Science & Technology with Union Minister for Science and Technology
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Cancers affecting mankind To date‚ none of the approximately 60 anticancer drugs used in conventional chemotherapy exhibits a selective uptake in tumor tissue and generally only a very small fraction of the administered dose reaches the tumor site. If surgery or radiotherapy is not effective‚ cure rates are in the range of 10% and‚ as a consequence‚ 90 % of chemotherapeutic agents are administered in the palliative setting to stabilize the disease or to improve the quality of life. With such a
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Term | Definition | * Reliability | Repetition‚ achieving consistent results | * Validity | Obtaining results consistent with what was being tested‚ correctly testing the aim‚ keeping everything else constant | * Accuracy | How accurate results are | * Dependent variable | Relies on independent variable‚ plotted on y-axis | * Independent variable | One you change‚ plotted on x-axis | What is the Human Genome? The human genome comprises a sequence of approximately 3 billion
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My fascination with research began with my father. Over a decade ago‚ he suffered a “widow maker” heart attack. Thanks to the prompt medical care he received at the hands of skilled physicians‚ he survived. Since that day‚ I have curiously observed as my father’s physicians have worked to scientifically and strategically optimize his health. My father’s ongoing journey has been an inspiration for my career as well as my research interests. It has been a privilege applying the lessons I have learned
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Physical entrapment of bioactive molecules in biomaterials is the most commonly used strategy. To date‚ different delivery vehicles‚ including polymeric microparticles‚ liposomes‚ hydrogels‚ foams‚ and bone cements‚ have been used for physically entrapping bone growth factors [35]. In the physical entrapment strategy‚ diffusion and scaffold degradation are the two possible mechanisms for fast release of GFs. Otherwise‚ the
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4.1.1. Paracellular pathway 4.1.2 Transcellular pathway Biochemical barrier 4.2. 5. Formulation strategies………………………………………………………………….14 5.1. 5.2. 5.3 5.4 5.5 5.6 5.7 5.8 Absorption enhancers Enzyme inhibitors Hydrogels Mucoadhesive systems Liposomes Nanoparticles Microparticles Cyclodextrins
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growth hormone 16. Wang‚ J.‚ Chua‚ K. M.‚ Wang‚ C. H. (2004) Stabilization and encapsulation of human immunoblobulin G into biodegradable microspheres 17. Sharma‚ A.‚ Sharma‚ U. S. (1997) Liposomes in drug delivery: progress and limitations. Int. 18. Niven‚ R. W.‚ Speer‚ M.‚ Schreier‚ H. (1991) Nebulization of liposomes. II. The effects of size and modelling of solute release profiles 19. Allen T. M. (1998) Liposomal drug formulations. Rationale for development and what we can expect for the future 20
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Advanced Drug Formulation Design to Optimize Therapeutic Outcomes DRUGS AND THE PHARMACEUTICAL SCIENCES A Series of Textbooks and Monographs Executive Editor James Swarbrick PharmaceuTech‚ Inc. Pinehurst‚ North Carolina Advisory Board Larry L. Augsburger University of Maryland Baltimore‚ Maryland Harry G. Brittain Center for Pharmaceutical Physics Milford‚ New Jersey Jennifer B. Dressman Johann Wolfgang Goethe University Frankfurt‚ Germany Anthony J. Hickey University of
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Aquaporin Water Channels Peter Agre Roderick MacKinnon All living matter is made up of cells. A single human being has as many as the stars in a galaxy‚ about one hundred thousand million. The various cells – e.g. muscle cells‚ kidney cells and nerve cells – act together in an intricate system in each one of us. Through pioneering discoveries concerning the water and ion channels of cells‚ this year’s Nobel Laureates Peter Agre and Roderick MacKinnon‚ have contributed to fundamental chemical
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