Fazal et al.‚ J Proteomics Bioinform 2013‚ 6:2 http://dx.doi.org/10.4172/jpb.1000256 Proteomics & Bioinformatics Research Article Research Article Open Access Open Access Multifactorial Understanding of Ion Abundance in Tandem Mass Spectrometry Experiments Zeeshan Fazal1‚ Bruce R Southey1‚ Jonathan V. Sweedler2‚3 and Sandra L. Rodriguez-Zas1‚3‚4* Department of Animal Sciences‚ University of Illinois Urbana-Champaign‚ IL‚ USA Department of Chemistry‚ University of Illinois Urbana-Champaign
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(phencyclidine)‚ and Marijuana. Gas chromatography/mass spectrometry is used to test hair and urine samples of possible drug abusers or job applicants‚ and it is the best method for the testing of drug use. Gas chromatography and mass spectrometry are two different methods for identifying chemical substances‚ and the two instruments have be coupled together to perform a highly complementary analytical function. The gas chromatograph and the mass spectrometer have theories behind how their techniques
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Eric Sorenson Leaf Spray: Direct Chemical Analysis of Plant Material by Mass Spectrometry Jiangjiang Liu‚† He Wang‚† R. Graham Cooks‚*‚‡‚§ and Zheng Ouyang*‚†‚§ †Weldon School of Biomedical Engineering‚ ‡Department of Chemistry‚ and §Center for Analytical Instrumentation Development‚ Purdue University‚ West Lafayette‚ Indiana 47907‚ United States Analytical Chemistry ACS Publications Published September 14‚ 2011 This research article written by the researchers Jiangjiang Liu‚ He Wang‚ R.
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Mass Spectrometer When you hear the words mass spectrometer‚ what do you think of? To some people‚ these words do not have any meaning; however the mass spectrometer has a great significance. The mass spectrometer has been a universal research tool‚ mostly involved in comparing the masses of atoms. Since the invention of this tool about 100 years ago‚ the mass spectrometer has been responsible for the description of molecular structure‚ the detection of isotopes‚ the classification of atomic
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ARTICLE Mass Spectrometry to Classify Non–Small-Cell Lung Cancer Patients for Clinical Outcome After Treatment With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Multicohort Cross-Institutional Study Fumiko Taguchi‚ Benjamin Solomon‚ Vanesa Gregorc‚ Heinrich Roder‚ Robert Gray‚ Kazuo Kasahara‚ Makoto Nishio‚ Julie Brahmer‚ Anna Spreafico‚ Vienna Ludovini‚ Pierre P. Massion‚ Rafal Dziadziuszko‚ Joan Schiller‚ Julia Grigorieva‚ Maxim Tsypin‚ Stephen W. Hunsucker‚ Richard Caprioli
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Module 2 Mass Spectroscopy [pic] [pic] Diagram of a mass spectrometer Stage 1: Ionisation The sample is injected as a vapour and the atoms are bombarded by fast moving electrons. This causes the molecule to fragment into two or more pieces. When a molecule or part thereof fragments‚ one portion would be positively charged while the second portion will be uncharged. All uncharged fragments are ultimately lost in the machine as mass spectrometers only work with positive ions. Stage 2: Acceleration
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ground state to excited state. Mass spectrometry: Mass spectrum gives the weight of a molecule Mass spectrometer converts sample into ions‚ and that these ions can be further fragmented (broken down) into smaller molecules. Ionisation can be achieved using various different techniques‚ electron ionisation‚ chemical ionisation and Fast atom bombardment. When sample is ionised the analyser portion of the mass spectrometer seperates the molecules based on their mass to charge ratio. A dector then
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Chapter 65 Quantitative methods of analysis Detection of end point in acid-alkali titration 8 Chapter 66 Instrumental analytical methods More about infrared spectroscopy More about mass spectrometry 12 15 Chapter 67 Contribution of analytical chemistry to our society Gas chromatography-mass spectrometry 32 PART XV ANALYTICAL CHEMISTRY Chapter 63 Detecting the presence of chemical species Action of heating solid sample strongly Heating the solid sample strongly is one of the preliminary
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Mass Spectrometry MS Interpretation General Interpretation Strategies i Wherever you see this symbol‚ it is important to access the on-line course as there is interactive material that cannot be fully shown in this reference manual. Aims and Objectives Aims and Objectives Aims • Introduces students to the principles of mass spectral interpretation. • Present fundamental concepts regarding mass spectral interpretation Objectives At the end of this Section you should be able to: •
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Revolutionary Analytical Methods for Biomolecules Mass Spectrometry (MR) and Nuclear Magnetic Resonance (NMR) are two very important fields of chemistry. The two fields had the hone to share the Nobel Prize in 2002. John B. Fenn‚ Koichi Tanaka‚ and Kurt Wuthrich have all had a part in further developing these methods of chemistry. Throughout this article it talks about why you should study biological macromolecules‚ how mass spectrometry is a method used to identify molecules‚ how each scientist
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