Review of 53BP1 inhibitory mechanism in Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks and Its Chemotherapeutic Implication BRCA1 is tumor repressor gene and plays an important role in breast cancer development. In the DNA double-stranded break (DSB) repair‚ loss of BRCA1 contributes to defective homologous recombination (HR) and predominant non-homologous end-joining (NHEJ)‚ which leads to significant defects in genomic stability with increased amount of
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Product and Service Offerings ................. 3 2.1 Digital Personalisation Methods used within Product/Service Offerings........................................................................................... 4 3 Online systems design –Mechanisms for customer influence and persuasion .......................................................................................... 6 3.1 Price transparency ................................................................... 8 3.2 Product transparency
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Article Review: How Many Object Can You Track?: Evidence for a Resource Limited Attentive Tracking Mechanism Before the paper by Alvarez & Franconeri (2007)‚ the general consensus was that people are able to track about 4 moving objects at any given time. However to some‚ it was clear that this issue is more complicated than the original view; which is the most likely inspiration for this further research. In the paper by Alvarez & Franconeri (2007)‚ it is found that it is not as simple
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the id‚ ego and superego‚ psychosexual stages of development and defence mechanisms. Sigmund Freud is a psychologist that he creates the first psychodynamic theory. This theory described how human’s personality was established and how they were operating‚ how the internal forces us to do or not do everything. Fred created the theory of the 3 levels of consciousness‚ psychosexual stage of development and defence mechanisms that described the idea and perspective about human personality. In this
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Nitration of Acetanilide Introduction When organic compounds are nitrated it changes the composition and reaction of the compounds.[4] We could benefit from these changes‚ nitration of acetanilide produces a product called p- Nirtoanoline. P-Nitroaniline is commonly used as an intermediate in the synthesis of dyes‚ antioxidants‚ pharmaceuticals and gasoline. P-Nitroaniline is also used in gum inhibitors‚ poultry medicines and as a corrosion inhibitor. [2] Nitration is a type of chemical
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synthesize five compounds employing several reactions such as acetylation‚ diazo coupling‚ nitration‚ bromination‚ and hydrolysis. The isolated products were analyzed with TLC and spectral data that determined most products were pure while some had a few impurities indicated by GC‚ LC‚ and a wide melting point range was shown for products 2 and 3. The presence of water in product 2 and 7 was indicated by the IR. Acetanilide and diazoaminobenzene had good yields compared to the other products with low-moderate
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electrophile in the nitration reaction‚ will attack the benzene ring and produces the nitrobenzene ring. Resonance-stabilized arenium ion is created when the nucleophilic carbon pi bond on the acetanilide reacts with the nitronium ion. The aromaticity of the compound is lost in this important step. Water‚ acting as the Lewis base‚ removes a proton from the carbon bonded to the nitro group‚ an aromatic benzyl structure is created again: nitroacetanilide; thus ending the nitration reaction (1). Next
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Why do some people believe that the market system is the best mechanism for allocating scarce resources and thereby encouraging a positive investment climate? Explain your answer There are three different types of ways of allocating scarce resources which are pure market economy‚ pure command economy and mixed economy. (Griffiths‚ Wall‚ 2008) Some people believe that the free market is the best mechanism for allocating scarce resources. A pure command economy is an economy in which the government
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than a passive mechanism for recording external information. Evaluate this claim‚ making reference to research findings. The concept that the memory is a constructive and dynamic system was originally introduced by Sir Frederic Bartlett‚ in the 1920’s. According to Bartlett‚ social factors influence one’s ability to remember‚ and in turn‚ can either change a person’s perception of a specific memory or distort the original memory. As opposed to the memory being a ‘passive mechanism’ which indicates
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Memory is a constructive and dynamic system rather than a passive mechanism for recording external information. Evaluate this claim‚ making reference to research findings. In order to evaluate this claim it is necessary to look at some of the research that has been carried out on memory. Most of the relevant research findings support the theory that memory is indeed a constructive and dynamic system but how much of what we store in our memory is down to active and conscious energy and how much
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