second step maleanilic acid undergoes the Michael addition of aniline and cyclization to yield I-phenyl-3-pl~enylaminopyrrolidine-2‚5dione 2 (Method A). Compound 2 can also he obtained in one step by using commercially available maleanilic acid (Merck) or‚ albeit in slightly lower overall yield‚ by refluxing maleic anhydride and aniline in 12molar ratio in acetic acid (Method B) (Fig. 1). The experiment is operationally simple‚ requiring simply manual stirring‚ filtration‚ and recrystallization
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through success in the field of Head and neck Cancer drug. They still had to get their phase 3 trial done (which looks like a market norm‚ though not a legal requirement). Erbitux which was developed by Imclone Systems in US had granted license to Merck to distribute the drug to India. Erbitux had already done 3 phase trial and they have got approval from European and US Drug agencies. They still not have received the approval from India drug authority (DGCI). But the same was expected soon. 1)
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Financial Reporting Practices Financial Reporting Practices Health Care Financial Accountin September 7‚ 2011 Ethical standards in financial reporting are essential. Tools have been set in place to ensure that this takes place. Some of these tools are agencies that have been established‚ elements of financial management‚ and Generally Accepted Accounting Principles. Several administrative agencies have been established to strive to create a more standardized and ethical standard
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Marilyn Pineda MS&E 266 Sweetwater Case Submitted January 14‚ 2013 Sweetwater Case Questions 1. From your point-of-view‚ what are the most important user needs in the water purification market? To save space‚ the entire list of important user needs is shown in the Table below along with Kano structure categories. The most important needs are designated “Must Haves” in Question 2: The two Water Quality criteria‚ the ability to pump through the unit directly into drinking water containers
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Ecstasy‚ or 3‚ 4 methylenedioxymethamphetamine‚ was first synthesized and patented in 1914‚ by the German drug company Merck. The original purpose of the drug was to be an appetite suppressant‚ however in 1970 it was given to clinical depressed patients to open them up and talk about their feelings. Then in 1986‚ Ecstasy was determined to cause brain damage (http://faculity.washington.edu/chudler/mdma.html). Ecstasy is used at the party and rave scene for its effects on the emotional state of
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STRATEGY IMPLEMENTATION I. What is strategy? * Defined from atleast 2 perspectives: 1. From the perspective of what an organization intends to do * The broad program for defining and achieving an organization’s objectives and implementing its missions 2. Pattern of the organization’s responses to the environment over time * Every organization has a relationship with its environment that can be examined and described * This view includes managers who are reactive—who respond
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The Teenage Years Growing up is a hard process‚ especially for those who are experiencing their adolescent years. Everyone who has gone through this process agrees that these years have been some of the most awkward and strangest years of their lives; the ‘teen years’ is a period of time in which the majority of people tend to have rebellious and irresponsible behavior‚ where it’s easy to feel isolated and where everything bad that happens is the “end of the world”. Teenagers seem to hate everything
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Preparation of SKEO The extraction of S. khuzistanica was performed by hydro distillation and clevenger apparatus for 5 hours. Once extraction was completed‚ the resulted essential oil was dehydrated using sodium sulfate (Merck). The essential oil was stored at temperature of 4ºC until using (12). In order to provide different concentrations of the extract‚ Dimethyl sulfoxide (DMSO) was used. Gas chromatography/mass spectrometry analysis of essential oil Isolation and measurement of the sample
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Investing helps your assets work for you. What is investing? Investing refers to the act of using your money to buy some sort of financial product or any other item‚ in the hope and expectation that the product will grow in value after you buy it. What are some type of investments? Almost anything you buy now that you think you can sell for more money later is considered an investment‚ including things like real estate‚ collectibles‚ stocks and bonds. So why invest? By investing your money‚ you
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CESAR A. BUENAVENTURA is Chairman of Buenaventura Echauz and Partners‚ Inc. He is currently a Director of the following: DMCI Holdings‚ Inc.‚ Semirara Mining Corporation‚ iPeople Inc.‚ D.M. Consunji‚ Inc.‚ Petroenergy Resources Corp.‚ AG&P Company of Manila‚ Inc.‚ Montecito Properties‚ Inc. (Vice Chairman)‚ Pilipinas Shell Petroleum Corp.‚ Philippine American Life Insurance Company and Manila International Airport Authority. He was chosen Management Man of the Year in 1985 by MAP and in
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