Multiple Myeloma Multiple Myeloma is a form of cancer which affects the plasma cells of the body‚ which are white blood cells. Multiple Myeloma‚ first described in 1848‚ is a disease “characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein.” To understand how Multiple Myeloma affects an infected person’s plasma cells‚ it helps to have a general understanding of how normal blood cells are formed and how they act. Most blood cells develop
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Multiple myeloma Multiple myeloma (also plasma cell myeloma also known as MM‚ myeloma‚ plasma cell myeloma‚ or as Kahler’s disease) is a progressive hematologic (blood) disease. It is a cancer of the plasma cell‚ an important part of the immune system that produces immunoglobulins (antibodies) to help fight infection and disease. The immune system is made up of several types of cells that work together to fight infections. Lymph cells (called lymphocytes) are the main type of cell in the adaptive
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What Is Plasmacytoma and Multiple Myeloma ENC1102 WK 3 February 2‚ 2013 What is plasmacytoma and multiple myeloma? Plasmacytoma is a cancer where abnormal plasma cells called myeloma cells form a tumor in the bone. Multiple myeloma is when you have more than one tumor. Multiple myeloma is a rare and life-threatening cancer of the bone marrow. When my husband was diagnosed with plasmacytoma in February of 2011‚ we were told that multiple myeloma was not hereditary‚ and his mother
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Diagnosis The 43-year old woman’s signs‚ symptoms and clinical tests lead to the diagnosis of multiple myeloma (MM). MM is classified as a malignant bone marrow neoplasia of a plasma cell‚ an activated B lymphocyte of hematopoietic stem cell linage. These monoclonal plasma cell secrete paraprotein‚ a protein found in the blood because of cancer or disease. In this case the plasma cell are secreting immunoglobin G (IgG) and free light chains. This can be detected via protein electrophoresis. These
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Multiple Myeloma is mainly caused by the Monoclonal gammopathy of unknown significance‚ or MGUS‚ and other uncontrollable factors. “MGUS is an asymptomatic blood disorder characterized by an abnormally elevated level of monoclonal protein‚ often discovered incidentally during testing for other disorders. Monoclonal proteins‚ or "M-proteins‚" are produced by plasma cells in the bone marrow.” Although it is not clear why‚ people who already been diagnosed with MGUS will most probably get multiple myeloma
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plitidepsin is the ideal candidate to treat multiple myeloma patients with poor bone marrow reserve who were heavily pre-treated (Mateos et al.‚ 2010). Multiple myeloma can be heavily pre-treated with chemotherapy‚ steroids‚ biological therapy‚ intensive treatment or even stem cell transplant (Cancer Research UK‚ 2015‚ para. 2). However‚ if the myeloma returns after these treatments given‚ doctors would advise various combinations of drugs which will cause the myeloma to be even more difficult to treat (Cancer
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inhibitor‚ Velcade (bortezomib) and the immunomodulatory drugs – Thalomid (thalidomide) and Revlimid (lenalidomide) have become the cornerstone of treatment for patients with Multiple Myeloma (MM) resulting in improved survival. However‚ eventually all patients relapse and new treatment options for Relapsed/ Refractory Multiple Myeloma (RRMM) are required to further improve survival and quality of life of this group of pts. Two new drugs have successfully fulfilled this need – POMALYST/ IMNOVID (pomalidomide
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A Defining Moment in my life Cancer‚ the word burned into my mind. My dad has cancer. The realization of this was so painful‚ that it was too much to bear. It was Multiple Myeloma‚ disease with which was not familiar. All that I knew was that my dad had cancer and my world was about to change forever. I always loved my dad and thought we had a strong bond‚ but our time together was limited. Between his work schedule and my school and sports schedules‚ we rarely saw each other. When he began his
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we got news that my uncle Paul had cancer‚ Multiple myeloma they had said‚ ‘’He’s in a lot of pain’’‚ his wife told my mom on the phone. In my head the words multiple myeloma kept flashing in neon lights‚ a voice kept repeating it‚ till finally I decided to check it out on the internet hating the fact that I knew absolutely nothing of this disease that apparently kills hundreds. As I read in the article‚ a few things stood out such as Multiple myeloma being a type of cancer that begins in the
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This week I decided to learn a little bit more about a disease called Multiple Myeloma. Multiple Myeloma is caused when a certain type of cell called the plasma cell is being produced “abnormally”. This means that the plasma cell isn’t doing its job and killing the bacteria that enters into your body because “[they]...crowd normal blood cells in your bones.” It creates tumors in your bone marrow and sometimes other parts of your body. As the bad plasma cells start to get higher in number‚ your bones
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