Synthesis of Aspirin Name: Xuanyi Li Teaching assistant: Deirdre Zwilling November 15‚ 2009 Purpose: To synthesize aspirin‚ a common analgesic drug‚ via nucleophilic acid-catalyzed substitution reaction of salicyclic acid with acetic anhydride. The whole reaction is catalyzed by phosphoric acid. (The experiment involved three parts: The synthesis of aspirin‚ the isolation and purification of aspirin‚ and the estimation of the purity of the final product.) [pic] Procedure[1]: A mixture
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Vol. 1 ACETIC ACID 115 ACETIC ACID 1. Introduction Acetic acid [64-19-7]‚ CH3COOH‚ is a corrosive organic acid having a sharp odor‚ burning taste‚ and pernicious blistering properties. It is found in ocean water‚ oilfield brines‚ rain‚ and at trace concentrations in many plant and animal liquids. It is central to all biological energy pathways. Fermentation of fruit and vegetable juices yields 2–12% acetic acid solutions‚ usually called vinegar (qv). Any sugar-containing sap or juice can
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Jennie K. Daniels Organic Chemistry 2121 11 February 2014 Synthesis of Aspirin Salicylic acid derivatives‚ or salicin‚ are found in the bark of the willow tree. In the 5th century B.C.‚ Hippocrates ground the bark into a powder‚ and later‚ the Natives Americans chewed on the bark to alleviate fever and pain1. In the 19th century‚ a German chemist by the name of Felix Hoffman wanted to find a medication that would ease
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Abstract – This multi-step synthesis uses aniline as the starting reagent to synthesize five compounds employing several reactions such as acetylation‚ diazo coupling‚ nitration‚ bromination‚ and hydrolysis. The isolated products were analyzed with TLC and spectral data that determined most products were pure while some had a few impurities indicated by GC‚ LC‚ and a wide melting point range was shown for products 2 and 3. The presence of water in product 2 and 7 was indicated by the IR. Acetanilide
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Folic Acid is a B vitamin‚ specifically B9. It is an essential nutrient required by the body to create healthy new cells. While we hear about it mostly in regards to pregnancy‚ it is important to understand that the need for folic acid goes even beyond this. Folic acid is essential for the body to create red blood cells which in turn prevents anemia. It is also plays an important role in the metabolism of homocysteine‚ an amino acid. The recommended dietary allowance (RDA) for all men and women
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Ribonucleic acid (RNA) is a ubiquitous family of large biological molecules that perform multiple vital roles in the coding‚ decoding‚ regulation‚ and expression of genes. Together with DNA‚ RNA comprises the nucleic acids‚ which‚ along with proteins‚ constitute the three major macromolecules essential for all known forms of life. Like DNA‚ RNA is assembled as a chain of nucleotides‚ but is usually single-stranded. Cellular organisms use messenger RNA (mRNA) to convey genetic information (often notated
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SYNTHESIS OF ESTERS USING GREEN AND NON-GREEN CHEMISTRY Abstract Esters are a class of organic compounds with the general formula RCOOR’. Ester also contributes the flavor and aromas in fruits and flowers. The esterification reactions will use in the procedure‚ which are the interaction of a carboxylic acid with an alcohol‚ aided by an inorganic acid catalyst (H2SO4). Moreover‚ the green method will not use any catalyst but using heating source instead (microwave). Based on the comparison of
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Lab Report Synthesis and Characterization of Aspirin (Acetylsalicylic Acid) The Synthesis and Characterization of Aspirin (Acetylsalicylic Acid). Summary: In this experiment‚ we produced 4.21 g of acetylsalicylic acid. Our theoretical yield was calculated to be 5.22 g. Therefore our % yield was determined to be 80.6%. The experimental boiling point range of acetylsalicylic acid was found to be 130-132° C. The true melting point of acetylsalicylic acid is 135° C‚ therefore our percent
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countries and could result in criminal charges being filed. If carried out by individuals unskilled at chemistry they could result in serious bodily harm. MDMA ("Ecstasy") is a semi-synthetic compound which can be made relatively easily from available precursors. Synthesis instructions exist which can be followed by an amateur with very little knowledge of chemistry. However‚ people with less than 2 years of college chemistry experience would probably not be capable of sucessfully synthesizing MDMA‚ and
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LIDE Learning Center‚ Inc. 6539 Isabel‚ Leyte Synthesis of Aspirin An Investigatory Project Presented to: Edmundo A. Quiñones Chemistry Teacher In Partial Fulfillment of the Requirements In Science and Technology III (Chemistry) Presented by: Kenneth Ivan P. Durano Cyrill Val G. Lozano March 6‚ 2010 APPROVAL SHEET This investigatory project entitled “The Synthesis of Aspirin” requirement for Science and Technology III (Chemistry) has
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