Biochemistry of Muscle Contraction Fred P. Guillergan M.D.‚ FPCP Outline histology and biochemistry of muscles (Striated & smooth) – Myosin – Actin‚ Tropomyosin‚ Troponin – Accessory proteins of muscles Biochemical events in muscle contraction Calcium‚ Ca2+-binding proteins and Ca2+ channels in muscle contraction Biochemistry of Cardiac & Smooth muscle contraction Energetics of muscle contraction ☻Able to understand the normal anatomy and physiology of different types of muscles ☻ Provide
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Exercise 8 Simple Muscle Contraction • 3 Phases AB - lag phase or latent phase - (shortest) 0.00sec‚ usually less than 0.01sec - brief period that exists between the application of the stimulus and the start of contraction BC - contraction‚ 0.05sec - peak - shortening of the muscle occur CD - relaxation period‚ 0.05 sec - Occurs when Ca+ is transported back in the sarcoplasmic reticulum Single muscle contraction= 100vib/sec (tuning fork)= 0.10 sec 10vib (result) Neuromuscular junction - formed when
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Muscle Test #1 Study Guide 1. What are the primary functions of muscles? What are skeletal muscles made of? Five Skeletal Muscle Functions 1.Produce movement of the skeleton •By pulling on tendons that then move bones 2.Maintain posture and body position 3.Support soft tissues •With the muscles of the abdominal wall and the pelvic floor 4.Guard entrances and exits •In the form of sphincters 5.Maintain body temperature •When contraction occurs‚ energy is used and converted to heat
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When it comes to muscle contraction‚ contraction takes place in the muscle fibers. Muscle fibers are the basic building blocks of the muscle and what allow muscles to contract. They appear as long cylinder cells that contain several nuclei. Contraction happens when the muscle receive signals from the nervous system and the Neuromuscular Junction obtains the muscular exchange where the synaptic bulb and the muscle fibers connect. muscle fibers are composed of myofibrils‚ which contain contractile
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Skeletal Muscle Lab Introduction: Motor neurons and muscle fibers are the building blocks of motor units and where they intersect is called the neuromuscular junciton. The region where the flattened end of a motor neuron transmits neural impulses to a muscle is the motor end-plate. The end plate potentials depolarizes skeletal muscle fibers caused by neurotransmitters binding to the postsynaptic membrane in the neuromuscular junction. The process of contraction of the muscle cell is called excitation-contraction
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Background Information Muscles in the human body can be classified into three different types- cardiac‚ smooth and skeletal muscles. The skeletal muscles are the muscles that can be controlled voluntarily‚ in things such walking and picking things up. The skeletal muscles are made up of bundles of muscle fibres (which are also known as myofibrils‚ as can be seen below). Each of the muscle fibres contain many sarcomeres‚ which is the most basic form of striated muscle tissue- they consist of two
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E 2 Skeletal Muscle Physiology O B J E C T I V E S 1. To define these terms used in describing muscle physiology: multiple motor unit summation‚ maximal stimulus‚ treppe‚ wave summation‚ and tetanus. 2. To identify two ways that the mode of stimulation can affect muscle force production. 3. To plot a graph relating stimulus strength and twitch force to illustrate graded muscle response. 4. To explain how slow‚ smooth‚ sustained contraction is possible in a skeletal muscle. 5. To graphically
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The muscle physiology of skeletal muscle was observed by using electrical‚ physical‚ and neural stimulations of an isolated gastrocnemius muscle from Rana pipiens. The gastrocnemius receives signals from the action potentials of the sciatic nerve. The muscle contraction is caused by the binding of a neurotransmitter once the action potential reaches the neuromuscular junction. Stimulation of the muscle and the sciatic nerve allows for recording and measuring of these properties. We observed twitch
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Muscles are all made of the same materials‚ a type of flexile tissue of thousands narrow tissues that make up all the muscles. There are three types of muscle tissue in the human body which are Cardiac‚ Smooth and Skeletal Muscles. Cardiac Muscles are muscles that conduct‚ forced‚ being completely in heart‚ responsible for pumping activity of heart‚ very heavy and solid. Smooth are non band‚ not under voluntary force found in comfortable organs of body accountable for growth like absorption of food
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Muscle Contraction Helpful links: Diagrams: http://themedicalbiochemistrypage.org/muscle.php http://classes.midlandstech.edu/carterp/Courses/bio210/chap09/lecture1.html Good explanations: http://science.howstuffworks.com/life/human-biology/muscle2.htm Quiz: http://www2.muw.edu/~jfortman/220practst2.html Flashcards: http://quizlet.com/17858377/physiology-ch-8-muscles-flash-cards/ http://quizlet.com/16553525/quiz-4-flash-cards/ http://quizlet
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