Medicines from willow bark – willow bark contain an active ingredient know as salicylic acid which used to make aspirin (pain reliever) Identifying salicylic acid Three chemical tests which are used to predict the structure of salicylic acid 1. Salicylic acid in aqueous solution is weakly acidic ( presence of COOH group) 2. Salicylic acid reacts with alcohols to form esters which give of strong odours. 3. When salicylic acid is added to a neutral solution such as iron chloride it turns intense pink
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Aspirin is prepared by the esterification of salicylic acid with acetic anhydride under acidic conditions. The phenol group in salicylic acid is replaced by a carboxyl group through electrophilic substitution. The mechanism for the reaction can be summarized as follows: Figure 11.4. Mechanism for the reaction of salicylic acid and acetic anhydride to form acetylsalicylic acid (aspirin) In this experiment‚ 85% phosphoric acid (H3PO4)‚ a strong acid‚ is used as a catalyst to speed up the reaction
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esterification by reacting salicylic acid with acetic anhydride with the presence of dehydrating agent‚ conc. sulphuric acid‚ to speed up the reaction. Having obtained the crude aspirin which was still impure‚ recrystallisation was conducted to remove the impurities. The aspirin harvested at the end of the experiment was 1.19g with the percentage yield of 37.8%. The melting point observed from the product ranged from 133°C to 137°C. Introduction Acetylsalicylic acid or commonly known as aspirin
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Synthesis of Aspirin (Acetylsalicylic Acid) Abstract: This experiment is about the synthesis of aspirin under laboratory conditions. Aspirin is prepared by reacting salicylic acid and acetic anhydride; in the presence of sulfuric acid. After fully dissolving the salicylic acid with acetic anhydride‚ the solution is cooled and cold water is then added. Once the crystals form they are then filtered and left to dry out. There mass is measured and recorded then the yield is calculated. Introduction:
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Experiment 4: Heating Under Reflux- Synthesis of Salicylic Acid from Wintergreen Oil Precious Ahmed ID# 6463614 Section 07‚ Friday afternoon Lab experiment performed on: Friday‚ January 19‚ 2013 Lab report submitted on: Friday‚ January 24‚ 2013 Introduction Before the synthetic aspirin of today‚ salicylic acid‚ which is the important ingredient found in aspirin‚ was extracted naturally from methyl salicylate found in Wintergreen oil‚ which could be found in certain plants. The purpose
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control wilt disease complex in abaca caused by Fusarium oxysporum f. sp. cubense (FOC) and Ralstonia solanacearum. Suspected biological elicitors (Fomes and Xanthomonas oryzae pv. oryzae or Xoo) and known chemical elicitors (Asprin or Acetyl Salicylic acid and Boost) were sprayed to the abaca tissue cultured seedlings at 15 days interval together with water and Nordox (fungicide with bactericidal activity) as checks. The sprayed seedlings were challenged by simultaneous inoculation with FOC and
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Experiment Four: Organic Synthesis of Aspirin Abstract The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid (aspirin)‚ and to become familiar with the optimum conditions needed for successful yields. Aspirin is produced from an acid catalyzed reaction between salicylic acid with acetic anhydride. The crystalline aspirin is synthesized and purified by recrystallization‚ although there is not a hundred percent yield due to sources of error. Introduction
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etc. Synthesis of Aspirin and Methyl Salicylate. The two compounds we will be preparing‚ aspirin (acetylsalicylic acid) and oil of wintergreen (methyl salicylate)‚ are both organic esters. An ester is a compound that is formed when an acid (containing the COOH group) reacts with an alcohol (a compound containing an -OH group). O C R1 O H O + H O C R2 R1 O R2 + H O H acid alcohol ester water Here R1 and R 2 represent groups such as CH3 - or CH3 CH2 -. The reaction type shown
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steps that would produce a better yield for future experiments is rinsing the flask with cold water to make sure that all product is transferred. Something else that can improve the experiment is allowing more than fifteen minutes for the Acetyl Salicylic acid to sit in the ice bath; this will allow for more product to crystallize out from solution and will allow for a higher percent yield. Another reason for product loss may be due to the temperature of the water that was used to wash the crude and
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Experiment #1: Synthesis of Salicylic Acid From Wintergreen Oil By: Asad Razzaq TA: Date: 18/01/2015 222/Lab Section 8 Introduction Salicylic acid‚ used in production of substances used worldwide such as commonly used analgesic drug aspirin(cite)‚ can be obtained from natural resources such as wintergreen oil or can be synthesized. Through a series of chemical reactions with cheap raw materials beginning with beginning with methyl salicylate and‚ it is a cheaper and more
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