HUMAN GENE THERAPY 22:1–10 (August 2011) ª Mary Ann Liebert‚ Inc. DOI: 10.1089/hum.2011.087 Review Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier 1 Shamim H. Rahman‚ Morgan L. Maeder‚2‚3 J. Keith Joung‚2‚3‚4 and Toni Cathomen1 Abstract Zinc-finger nucleases (ZFNs) are a powerful tool that can be used to edit the human genome ad libitum. The technology has experienced remarkable development in the last few years with regard to both the target site specificity and the
Premium DNA Genetics Gene
Captain‚” she ordered impulsively‚ “’Twill be an easy thing to catch.” She is outspoken and competitive‚ “She could not help laughing as she passed him‚ and with a feeling of triumph she beat him to the boat.” Also‚ Kit is thoughtless when she insults Nat about the smell of the Dolphin‚ and when she jumps after the doll‚ when Prudence drops it into the water. Kit is also very immature compared to the people of Connecticut who are much too disciplined to Kit’s point of view. Lastly‚ she is somewhat arrogant
Premium Friendship Witchcraft Love
Lesley is a spoiled‚ pretty‚ Jewish‚ fourteen year old living in Canada. As the story progresses we see Lesley change to a caring and mature person by overcoming the differences in her new life. Two other important characters are Nat Shelby and Mustapha. Lesley’s father‚ Nat Shelby is the person who decided the family needed to live in Israel. Mr. Shelby decides he doesn’t want his daughter growing up as a spoiled uncaring princess. Mustapha‚ other important character‚ is an Arab boy who Lesley watches
Premium Israel Character Jordan
Beginning her tale unannounced‚ the Wife of Bath bursts onto the scene taking the entire pilgrimage by surprise. Her agenda is to engage in the medieval debate on marriage‚ confronting the scholarly authority of the church from the standpoint of common experience. Her main emphasis is on maistrie and believes that women should have the upper hand in marriage‚ making winning and retaining maistrie their main objective. She also refutes canon law which says you are only allowed one husband‚ distorting
Premium Marriage Husband
-runlevel 0- shuts down the system‚ runlevel 1- brings the system to single-user/resue mode‚ runlevel 2‚3‚4- brings the system to multiuser textual mode‚ runlevel 5- brings the system to multiuser graphical mode‚ runlevel 6- reboots the system. by default Fedora uses 5‚ Telinit utility allows a user working with root privileges to bring the system down‚ reboot‚ or change between runlevels. who –r displays current runlevel -any directories you do not create file systems for automatically become part
Premium IP address File system
making the world globalized and as steps were taken toward modernization in the 1700s‚ the world underwent many changes‚ however still keeping some of its initial traditions. From 1700-1900 in Eastern Europe‚ the economy had switched from agricultural to manufacturing due to the growth of factories and industry in the 1800s and serfdom was abolished‚ however the tsars still remained the center of authority. In 1700‚ the world was becoming globalized as the New World was brought into the world economy
Premium Russia Russian Empire Nicholas II of Russia
CHAPTER 4—ESSENTIALS OF PLANNING MULTIPLE CHOICE 1. Planning is a. a complex and comprehensive process involving interrelated stages. b. organizing‚ implementing‚ and controlling. c. finding the best person for a job. d. communicating effectively with stakeholders. 2. Strategic plans are designed to a. implement operational plans. b. establish day-by-day procedures. c. shape the destiny of the firm. d. carrying out the functions of management. 3. The purpose of tactical planning is to a. establish
Premium Strategic management Management
NeuroImage 56 (2011) 385–386 Contents lists available at ScienceDirect NeuroImage j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / y n i m g Editorial Multivariate decoding and brain reading: Introduction to the special issue a r t i c l e i n f o a b s t r a c t In recent years‚ the scope of neuroimaging research has been substantially extended by multivariate decoding methodology. Decoding techniques allow us to address a number of important
Premium Brain Cerebral cortex Electroencephalography
Throughout essay “In the Kitchen‚” Henry Louis Gates Junior recalls a time when he and his friends and family constantly tried to straighten their African American “kinky” hair. They did this to try to fit in with white people. The writer is using his personal experience as an African American straightening his hair to show how black people felt about assimilating into white society. It was very difficult for blacks to fit in with white people but he remembers how this difficult time brought the
Premium Black people White people Race
known to the other party.” Restatement of the Law of Contracts‚ Vol. I‚ 71‚ p. 74. and “Specific performance‚ it is true‚ is not a matter of absolute or arbitrary right‚ but is addressed to the reasonable and sound discretion of the court.” First Nat. Bank v. Roanoke Oil Co.‚ supra‚ 169‚ VA. At p. 116‚ 192 S.E. at p. 771. Analysis:
Premium Contract Supreme Court of the United States Appeal