corrosive‚ harmful if inhaled‚ flammable and can cause burns (handle in fume hood) Gloves are recommended to avoid chemical contact with skin Reaction Scheme: Conversion of acetanilide to p-bromoacetanilide Procedure: To a 125 mL Erlenmeyer flask containing a mixture of 95% ethanol (6 mL) and acetic acid (5 mL)‚ dissolve acetanilide (7.4 mmol) and sodium bromide (1.8 g). Place the reaction flask in an ice bath (at least 5oC) for 5 minutes (keep this reaction in the hood). Add sodium hypochlorite (8
Premium Ethanol Acetic acid Solvent
In the first part of this experiment acetic anhydride was used to prepare acetanilide which could then be readily brominated to form a mono-brominated product‚ with the bromine positioned at either the ortho‚ meta or para position on the aromatic ring. Acetic anhydride is very reactive towards nucleophiles and this reactivity is the result of the difference in electronegativities of the carbon and oxygen atoms that are bonded in acetic anhydride. This difference in electronegativities causes one
Premium Oxygen Atom Electric charge
and chemical tests todifferentiate their intrinsic physical properties and chemical properties in terms ofstructure and behaviour. Nitration test (test for the presence of aromatic ring)‚ Bromine test (test for the presence of unsaturation)‚ and Basic oxidation test (test for an alkyl substituted benzine) were done. We were given an unknown which we tested (Nitration‚Bromine‚ Basic oxidation) and found out that it was an aromatic unsaturated hydro carbon. Keywords: hydrocarbons‚ hexane/ cyclohexane
Free Benzene Hydrocarbon
Lab 6: Electrophilic Aromatic Substitution(1) Nitration of Methyl Benzoate(2) Synthesis of 1‚4-Di-t-butyl-2‚5-dimethoxybenzene byFriedel-Crafts Alkylation of 1‚4-DimethoxybenzenePurpose1)To carry out the nitration of methyl benzoate‚ and then identify the major product formed (position at which nitro-group substitution takes place) by thin-layer chromatography (TLC)‚ the percent yield and the melting point range. 2)To synthesize 1‚4-Di-t-butyl-2‚5-dimethoxybenzene by Friedel-Crafts Alkylation of
Premium Sulfuric acid Benzene Carbon
Preparation of 4-bromoaniline Introduction Aromatic compounds tend to undergo electrophilic aromatic substitutions rather than addition reactions. Substitution of a new group for a hydrogen atom takes place via a resonance-stabilized carbocation. As the benzene ring is quite electron-rich‚ it almost always behaves as a nucleophile in a reaction which means the substitution on benzene occurs by the addition of an electrophile. Substituted benzenes tend to react at predictable positions. Alkyl groups
Premium Benzene Amide Aromaticity
the procedure outlined in Appendix A of the Lab Manual‚ approximately equal samples of p-Nitrophenol and acetanilide‚ which are known to have the same melting range of 113-114 degrees Celcius‚ were taken and inserted into the melting point apparatus. The melting points of the compounds were noted and found to be very similar. Next‚ approximately equal amounts of p-Nitrophenol and acetanilide were mixed on a clean watch glass. A sample of the mixture was placed in the Mel-temp apparatus as before
Premium Chemical compound Chemical substance Temperature
Compounds by Solvent Extraction Introduction The purpose of this experiment was to use solvent extraction techniques in order to separate a mixture consisting of a carboxylic acid (p-toulic acid)‚ a phenol (p-tert-butylphenol)‚ and a neutral compound (acetanilide). Extraction is the process of selectively dissolving one or more of the compounds of a mixture into an appropriate solvent‚ the solution that contains these dissolved compounds is called an extract (Manion‚ 2004). Impurities that are present
Premium Chemistry Solubility Solvent
Mapua Institute of Technology Organic Chemistry Laboratory 2 Final Report Factors Affecting the Relative Rates of Electrophilic Aromatic Substitution Reaction Justiniano‚ Priscilla Raiza N. School of Chemical Engineering and Chemistry‚ Mapua Institute of Technology‚ Intramuros‚ Manila‚ Philippines Experiment No.1‚ Submitted on August 6‚ 2011 at N402. Abstract EXPERIMENT NUMBER ONE IS ALL ABOUT THE ELECTROPHILIC SUBSTITUTION OF AROMATIC COMPOUNDS. AROMATIC COMPOUNDS ARE THOSE ORGANIC
Premium Organic chemistry Solvent Chemical reaction
purity. For ortho-nitrophenol we had 60% recovery and for para 160% recovery. Our melting point ranges were ortho: 45-46°C and para 64-95°C. Introduction: Nitration: In phenols‚ -OH group strongly activates the ring system. As a result‚ phenols are susceptible to oxidation in the presence of concentrated nitric acid (HNO3). Thus‚ nitration of phenols is carried out with dilute nitric acid and results in the formation of o-nitrophenol and p-nitrophenol. The o-nitrophenol is steam volatile and the
Premium Distillation Chemistry Water
Experiment 3 Objectives Separation by Solvent Extraction To separate a mixture consisting of a carboxylic acid and a neutral compound by using solvent extraction techniques. Introduction Frequently‚ organic chemists must separate an organic compound from a mixture of compounds‚ often derived from natural sources or products of synthetic reactions. One technique used to separate the mixture compounds is called extraction. Extraction is a process
Premium Solubility Solvent Acetic acid